Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review

Richard Teofilo Atallah,1 Maria Virginia Castanos,2,3 Richard Najac,2 Eric Donnenfeld41Rutgers New Jersey Medical School, Newark, NJ, USA; 2Department of Research, Eye and Ear Infirmary of Mount Sinai, New York, NY, USA; 3Department of Ophthalmology, New York Eye & Ear Infirmary of Mount Sin...

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Autores principales:	Atallah RT, Castanos MV, Najac R, Donnenfeld E
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Lifitegrast integrin antagonist dry eye disease (DED) eye dryness inflammation ocular surface disease Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/8553e4c7ca3145ed8b719629231c4b3e
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spelling	oai:doaj.org-article:8553e4c7ca3145ed8b719629231c4b3e2021-12-02T03:37:21ZSix months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review1177-5483https://doaj.org/article/8553e4c7ca3145ed8b719629231c4b3e2019-06-01T00:00:00Zhttps://www.dovepress.com/six-months-treatment-with-lifitegrast-in-patients-with-moderate-to-sev-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Richard Teofilo Atallah,1 Maria Virginia Castanos,2,3 Richard Najac,2 Eric Donnenfeld41Rutgers New Jersey Medical School, Newark, NJ, USA; 2Department of Research, Eye and Ear Infirmary of Mount Sinai, New York, NY, USA; 3Department of Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, NY, USA; 4Ophthalmic Consultants of Long Island, New York University Medical Center, Garden City, NY, USAPurpose: To evaluate 6-month treatment benefits with lifitegrast ophthalmic solution 5% in symptomatic dry eye patients.Setting: Retrospective chart analysis.Method: A retrospective chart review was conducted in 168 patients (111 females and 57 males) who presented with symptoms of chronic dry eye disease and were treated with lifitegrast 5% ophthalmic solution for 6 months. Collected symptom data included improvement of eye dryness, tearing, eye pain, fluctuation in vision, foreign body sensation, itching, grittiness, burning and contact lens intolerance if applicable. Collected clinical signs included changes in superficial punctate keratitis, corneal fluorescein staining, conjunctival hyperemia and presence of tear debris.Results: Treatment with lifitegrast ophthalmic solution 5% twice daily for 6 months significantly improved majority of dry eye symptoms reported by patients. Improvements were also observed in corneal and conjunctival staining and tear debris for most of the patients reviewed.Conclusion: Treatment with lifitegrast twice a day for 6 months improved both signs and symptoms of chronic dry eye.Keywords: lifitegrast, integrin antagonist, dry eye disease, DED, eye dryness, inflammation, ocular surface diseaseAtallah RTCastanos MVNajac RDonnenfeld EDove Medical PressarticleLifitegrastintegrin antagonistdry eye disease (DED)eye drynessinflammationocular surface diseaseOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 13, Pp 1033-1037 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Lifitegrast integrin antagonist dry eye disease (DED) eye dryness inflammation ocular surface disease Ophthalmology RE1-994
spellingShingle	Lifitegrast integrin antagonist dry eye disease (DED) eye dryness inflammation ocular surface disease Ophthalmology RE1-994 Atallah RT Castanos MV Najac R Donnenfeld E Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review
description	Richard Teofilo Atallah,1 Maria Virginia Castanos,2,3 Richard Najac,2 Eric Donnenfeld41Rutgers New Jersey Medical School, Newark, NJ, USA; 2Department of Research, Eye and Ear Infirmary of Mount Sinai, New York, NY, USA; 3Department of Ophthalmology, New York Eye & Ear Infirmary of Mount Sinai, New York, NY, USA; 4Ophthalmic Consultants of Long Island, New York University Medical Center, Garden City, NY, USAPurpose: To evaluate 6-month treatment benefits with lifitegrast ophthalmic solution 5% in symptomatic dry eye patients.Setting: Retrospective chart analysis.Method: A retrospective chart review was conducted in 168 patients (111 females and 57 males) who presented with symptoms of chronic dry eye disease and were treated with lifitegrast 5% ophthalmic solution for 6 months. Collected symptom data included improvement of eye dryness, tearing, eye pain, fluctuation in vision, foreign body sensation, itching, grittiness, burning and contact lens intolerance if applicable. Collected clinical signs included changes in superficial punctate keratitis, corneal fluorescein staining, conjunctival hyperemia and presence of tear debris.Results: Treatment with lifitegrast ophthalmic solution 5% twice daily for 6 months significantly improved majority of dry eye symptoms reported by patients. Improvements were also observed in corneal and conjunctival staining and tear debris for most of the patients reviewed.Conclusion: Treatment with lifitegrast twice a day for 6 months improved both signs and symptoms of chronic dry eye.Keywords: lifitegrast, integrin antagonist, dry eye disease, DED, eye dryness, inflammation, ocular surface disease
format	article
author	Atallah RT Castanos MV Najac R Donnenfeld E
author_facet	Atallah RT Castanos MV Najac R Donnenfeld E
author_sort	Atallah RT
title	Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review
title_short	Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review
title_full	Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review
title_fullStr	Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review
title_full_unstemmed	Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review
title_sort	six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/8553e4c7ca3145ed8b719629231c4b3e
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Six months&#39; treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review

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Six months' treatment with lifitegrast in patients with moderate-to-severe symptomatic dry eye: a retrospective chart review