Vitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study

Abstract Hepatic fibrosis is the net accumulation of matrix tissue components which controlled by pro-fibrolytic enzymes, matrix metalloproteinases (MMPs), and pro-fibrotic cytokine, TGF-β1, and enzymes, tissue inhibitors of MMPs (TIMPs). Vitamin D (VD) supplementation has been shown to reverse thes...

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Autores principales:	Piyawat Komolmit, Sayamon Kimtrakool, Sirinporn Suksawatamnuay, Kessarin Thanapirom, Kanita Chattrasophon, Panarat Thaimai, Chintana Chirathaworn, Yong Poovorawan
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/85540fb7084a465bae4ba16d2b6ad82a
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spelling	oai:doaj.org-article:85540fb7084a465bae4ba16d2b6ad82a2021-12-02T11:52:44ZVitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study10.1038/s41598-017-09512-72045-2322https://doaj.org/article/85540fb7084a465bae4ba16d2b6ad82a2017-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-09512-7https://doaj.org/toc/2045-2322Abstract Hepatic fibrosis is the net accumulation of matrix tissue components which controlled by pro-fibrolytic enzymes, matrix metalloproteinases (MMPs), and pro-fibrotic cytokine, TGF-β1, and enzymes, tissue inhibitors of MMPs (TIMPs). Vitamin D (VD) supplementation has been shown to reverse these processes in vitro and in vivo. This study sought to determine the effect of VD supplementation on serum fibrotic markers in chronic hepatitis C (CHC) patients. Fifty-four CHC patients with VD deficiency were randomized into two groups, a VD group (n = 29) and a placebo group (n = 29). The serum levels of 25-hydroxy VD, TGF-β1, TIMP-1, MMP2 and MMP9 were measured at baseline and at the end of the 6-week study period. Upon correction of VD levels, TGF-β1 and TIMP-1 levels were decreased, and the MMP2 and MMP9 levels were significantly increased in the VD group. A comparison of the mean changes (delta) in the markers between groups showed that TGF-β1 and TIMP-1 levels were significantly decreased and the MMP2 and MMP9 were significantly higher in the VD group than in the placebo group. By using CHC patients as a model, this study provides additional evidence that VD plays an important role in the reversal of hepatic fibrogenesis.Piyawat KomolmitSayamon KimtrakoolSirinporn SuksawatamnuayKessarin ThanapiromKanita ChattrasophonPanarat ThaimaiChintana ChirathawornYong PoovorawanNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Piyawat Komolmit Sayamon Kimtrakool Sirinporn Suksawatamnuay Kessarin Thanapirom Kanita Chattrasophon Panarat Thaimai Chintana Chirathaworn Yong Poovorawan Vitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study
description	Abstract Hepatic fibrosis is the net accumulation of matrix tissue components which controlled by pro-fibrolytic enzymes, matrix metalloproteinases (MMPs), and pro-fibrotic cytokine, TGF-β1, and enzymes, tissue inhibitors of MMPs (TIMPs). Vitamin D (VD) supplementation has been shown to reverse these processes in vitro and in vivo. This study sought to determine the effect of VD supplementation on serum fibrotic markers in chronic hepatitis C (CHC) patients. Fifty-four CHC patients with VD deficiency were randomized into two groups, a VD group (n = 29) and a placebo group (n = 29). The serum levels of 25-hydroxy VD, TGF-β1, TIMP-1, MMP2 and MMP9 were measured at baseline and at the end of the 6-week study period. Upon correction of VD levels, TGF-β1 and TIMP-1 levels were decreased, and the MMP2 and MMP9 levels were significantly increased in the VD group. A comparison of the mean changes (delta) in the markers between groups showed that TGF-β1 and TIMP-1 levels were significantly decreased and the MMP2 and MMP9 were significantly higher in the VD group than in the placebo group. By using CHC patients as a model, this study provides additional evidence that VD plays an important role in the reversal of hepatic fibrogenesis.
format	article
author	Piyawat Komolmit Sayamon Kimtrakool Sirinporn Suksawatamnuay Kessarin Thanapirom Kanita Chattrasophon Panarat Thaimai Chintana Chirathaworn Yong Poovorawan
author_facet	Piyawat Komolmit Sayamon Kimtrakool Sirinporn Suksawatamnuay Kessarin Thanapirom Kanita Chattrasophon Panarat Thaimai Chintana Chirathaworn Yong Poovorawan
author_sort	Piyawat Komolmit
title	Vitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study
title_short	Vitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study
title_full	Vitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study
title_fullStr	Vitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study
title_full_unstemmed	Vitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study
title_sort	vitamin d supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis c patients: a randomized, double-blind, placebo-controlled study
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/85540fb7084a465bae4ba16d2b6ad82a
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Vitamin D supplementation improves serum markers associated with hepatic fibrogenesis in chronic hepatitis C patients: A randomized, double-blind, placebo-controlled study

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