Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization

C-H activation is a powerful method to form functionalised molecules, but is particularly challenging for unactivated sp3sites. Here the authors report a directing-group-free radical cascade process for converting vinyl azides and carboxylic acids to tetralone derivatives in high diastereoselectivit...

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Autores principales: Wei Shu, Adriana Lorente, Enrique Gómez-Bengoa, Cristina Nevado
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Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/8554b14d36544c84abbb58a4cb4fdf3a
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spelling oai:doaj.org-article:8554b14d36544c84abbb58a4cb4fdf3a2021-12-02T17:06:18ZExpeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization10.1038/ncomms138322041-1723https://doaj.org/article/8554b14d36544c84abbb58a4cb4fdf3a2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13832https://doaj.org/toc/2041-1723C-H activation is a powerful method to form functionalised molecules, but is particularly challenging for unactivated sp3sites. Here the authors report a directing-group-free radical cascade process for converting vinyl azides and carboxylic acids to tetralone derivatives in high diastereoselectivity.Wei ShuAdriana LorenteEnrique Gómez-BengoaCristina NevadoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Wei Shu
Adriana Lorente
Enrique Gómez-Bengoa
Cristina Nevado
Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization
description C-H activation is a powerful method to form functionalised molecules, but is particularly challenging for unactivated sp3sites. Here the authors report a directing-group-free radical cascade process for converting vinyl azides and carboxylic acids to tetralone derivatives in high diastereoselectivity.
format article
author Wei Shu
Adriana Lorente
Enrique Gómez-Bengoa
Cristina Nevado
author_facet Wei Shu
Adriana Lorente
Enrique Gómez-Bengoa
Cristina Nevado
author_sort Wei Shu
title Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization
title_short Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization
title_full Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization
title_fullStr Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization
title_full_unstemmed Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization
title_sort expeditious diastereoselective synthesis of elaborated ketones via remote csp3–h functionalization
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/8554b14d36544c84abbb58a4cb4fdf3a
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