Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization
C-H activation is a powerful method to form functionalised molecules, but is particularly challenging for unactivated sp3sites. Here the authors report a directing-group-free radical cascade process for converting vinyl azides and carboxylic acids to tetralone derivatives in high diastereoselectivit...
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2017
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oai:doaj.org-article:8554b14d36544c84abbb58a4cb4fdf3a2021-12-02T17:06:18ZExpeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization10.1038/ncomms138322041-1723https://doaj.org/article/8554b14d36544c84abbb58a4cb4fdf3a2017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13832https://doaj.org/toc/2041-1723C-H activation is a powerful method to form functionalised molecules, but is particularly challenging for unactivated sp3sites. Here the authors report a directing-group-free radical cascade process for converting vinyl azides and carboxylic acids to tetralone derivatives in high diastereoselectivity.Wei ShuAdriana LorenteEnrique Gómez-BengoaCristina NevadoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-8 (2017) |
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Science Q Wei Shu Adriana Lorente Enrique Gómez-Bengoa Cristina Nevado Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization |
description |
C-H activation is a powerful method to form functionalised molecules, but is particularly challenging for unactivated sp3sites. Here the authors report a directing-group-free radical cascade process for converting vinyl azides and carboxylic acids to tetralone derivatives in high diastereoselectivity. |
format |
article |
author |
Wei Shu Adriana Lorente Enrique Gómez-Bengoa Cristina Nevado |
author_facet |
Wei Shu Adriana Lorente Enrique Gómez-Bengoa Cristina Nevado |
author_sort |
Wei Shu |
title |
Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization |
title_short |
Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization |
title_full |
Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization |
title_fullStr |
Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization |
title_full_unstemmed |
Expeditious diastereoselective synthesis of elaborated ketones via remote Csp3–H functionalization |
title_sort |
expeditious diastereoselective synthesis of elaborated ketones via remote csp3–h functionalization |
publisher |
Nature Portfolio |
publishDate |
2017 |
url |
https://doaj.org/article/8554b14d36544c84abbb58a4cb4fdf3a |
work_keys_str_mv |
AT weishu expeditiousdiastereoselectivesynthesisofelaboratedketonesviaremotecsp3hfunctionalization AT adrianalorente expeditiousdiastereoselectivesynthesisofelaboratedketonesviaremotecsp3hfunctionalization AT enriquegomezbengoa expeditiousdiastereoselectivesynthesisofelaboratedketonesviaremotecsp3hfunctionalization AT cristinanevado expeditiousdiastereoselectivesynthesisofelaboratedketonesviaremotecsp3hfunctionalization |
_version_ |
1718381685122269184 |