Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

ADHD is often found to be comorbid with disruptive behavior disorders, but the genetic loci underlying this comorbidity are unknown. Here, the authors have performed a GWAS meta-analysis of ADHD with disruptive behavior disorders, finding three genome-wide significant loci in Europeans, and replicat...

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Autores principales:	Ditte Demontis, Raymond K. Walters, Veera M. Rajagopal, Irwin D. Waldman, Jakob Grove, Thomas D. Als, Søren Dalsgaard, Marta Ribasas, Jonas Bybjerg-Grauholm, Maria Bækvad-Hansen, Thomas Werge, Merete Nordentoft, Ole Mors, Preben Bo Mortensen, ADHD Working Group of the Psychiatric Genomics Consortium (PGC), Bru Cormand, David M. Hougaard, Benjamin M. Neale, Barbara Franke, Stephen V. Faraone, Anders D. Børglum
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/855814c9c9b34d829fa2d9a6f7c91c33
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spelling	oai:doaj.org-article:855814c9c9b34d829fa2d9a6f7c91c332021-12-02T14:16:14ZRisk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder10.1038/s41467-020-20443-22041-1723https://doaj.org/article/855814c9c9b34d829fa2d9a6f7c91c332021-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20443-2https://doaj.org/toc/2041-1723ADHD is often found to be comorbid with disruptive behavior disorders, but the genetic loci underlying this comorbidity are unknown. Here, the authors have performed a GWAS meta-analysis of ADHD with disruptive behavior disorders, finding three genome-wide significant loci in Europeans, and replicating one in a Chinese cohort.Ditte DemontisRaymond K. WaltersVeera M. RajagopalIrwin D. WaldmanJakob GroveThomas D. AlsSøren DalsgaardMarta RibasasJonas Bybjerg-GrauholmMaria Bækvad-HansenThomas WergeMerete NordentoftOle MorsPreben Bo MortensenADHD Working Group of the Psychiatric Genomics Consortium (PGC)Bru CormandDavid M. HougaardBenjamin M. NealeBarbara FrankeStephen V. FaraoneAnders D. BørglumNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ditte Demontis Raymond K. Walters Veera M. Rajagopal Irwin D. Waldman Jakob Grove Thomas D. Als Søren Dalsgaard Marta Ribasas Jonas Bybjerg-Grauholm Maria Bækvad-Hansen Thomas Werge Merete Nordentoft Ole Mors Preben Bo Mortensen ADHD Working Group of the Psychiatric Genomics Consortium (PGC) Bru Cormand David M. Hougaard Benjamin M. Neale Barbara Franke Stephen V. Faraone Anders D. Børglum Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
description	ADHD is often found to be comorbid with disruptive behavior disorders, but the genetic loci underlying this comorbidity are unknown. Here, the authors have performed a GWAS meta-analysis of ADHD with disruptive behavior disorders, finding three genome-wide significant loci in Europeans, and replicating one in a Chinese cohort.
format	article
author	Ditte Demontis Raymond K. Walters Veera M. Rajagopal Irwin D. Waldman Jakob Grove Thomas D. Als Søren Dalsgaard Marta Ribasas Jonas Bybjerg-Grauholm Maria Bækvad-Hansen Thomas Werge Merete Nordentoft Ole Mors Preben Bo Mortensen ADHD Working Group of the Psychiatric Genomics Consortium (PGC) Bru Cormand David M. Hougaard Benjamin M. Neale Barbara Franke Stephen V. Faraone Anders D. Børglum
author_facet	Ditte Demontis Raymond K. Walters Veera M. Rajagopal Irwin D. Waldman Jakob Grove Thomas D. Als Søren Dalsgaard Marta Ribasas Jonas Bybjerg-Grauholm Maria Bækvad-Hansen Thomas Werge Merete Nordentoft Ole Mors Preben Bo Mortensen ADHD Working Group of the Psychiatric Genomics Consortium (PGC) Bru Cormand David M. Hougaard Benjamin M. Neale Barbara Franke Stephen V. Faraone Anders D. Børglum
author_sort	Ditte Demontis
title	Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
title_short	Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
title_full	Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
title_fullStr	Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
title_full_unstemmed	Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
title_sort	risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/855814c9c9b34d829fa2d9a6f7c91c33
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Risk variants and polygenic architecture of disruptive behavior disorders in the context of attention-deficit/hyperactivity disorder

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