Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine
This work demonstrates a facile electropolymerization of a <span style="font-variant: small-caps;">dl</span>-methionine (<span style="font-variant: small-caps;">dl</span>-met) conducting polymeric film on a gold nanoparticle (AuNPs)-modified glassy carbon...
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| Main Authors: | , , |
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| Format: | article |
| Language: | EN |
| Published: |
MDPI AG
2021
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| Subjects: | |
| Online Access: | https://doaj.org/article/855a04fe479c417cb769a073fa849f8c |
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| Summary: | This work demonstrates a facile electropolymerization of a <span style="font-variant: small-caps;">dl</span>-methionine (<span style="font-variant: small-caps;">dl</span>-met) conducting polymeric film on a gold nanoparticle (AuNPs)-modified glassy carbon electrode (GCE). The resulting sensor was successfully applied for the sensitive detection of paroxetine·HCl (PRX), a selective serotonin (5-HT) reuptake inhibitor (SSRIs), in its pharmaceutical formulations. The sensor was characterized morphologically using scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM) and electrochemical techniques such as differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The proposed sensor, poly (<span style="font-variant: small-caps;">dl</span>-met)/AuNPs-GCE, exhibited a linear response range from 5 × 10<sup>−11</sup> to 5 × 10<sup>−8</sup> M and from 5 × 10<sup>−8</sup> to 1 × 10<sup>−4</sup> M using DPV with lowest limit of detection (LOD = 1 × 10<sup>−11</sup> M) based on (S/N = 3). The poly (<span style="font-variant: small-caps;">dl</span>-met)/AuNPs-GCE sensor was successfully applied for PRX determination in three different pharmaceutical formulations with percent recoveries between 96.29% and 103.40% ± SD (±0.02 and ±0.58, respectively). |
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