Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine

This work demonstrates a facile electropolymerization of a <span style="font-variant: small-caps;">dl</span>-methionine (<span style="font-variant: small-caps;">dl</span>-met) conducting polymeric film on a gold nanoparticle (AuNPs)-modified glassy carbon...

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Autores principales:	Saedah R. Al-Mhyawi, Riham K. Ahmed, Rasha M. El Nashar
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	paroxetine poly (<span style="font-variant: small-caps">dl</span>-methionine) electropolymerization selective serotonin reuptake inhibitor voltammetry gold nanoparticles Organic chemistry QD241-441
Acceso en línea:	https://doaj.org/article/855a04fe479c417cb769a073fa849f8c
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spelling	oai:doaj.org-article:855a04fe479c417cb769a073fa849f8c2021-11-25T18:49:02ZApplication of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine10.3390/polym132239812073-4360https://doaj.org/article/855a04fe479c417cb769a073fa849f8c2021-11-01T00:00:00Zhttps://www.mdpi.com/2073-4360/13/22/3981https://doaj.org/toc/2073-4360This work demonstrates a facile electropolymerization of a <span style="font-variant: small-caps;">dl</span>-methionine (<span style="font-variant: small-caps;">dl</span>-met) conducting polymeric film on a gold nanoparticle (AuNPs)-modified glassy carbon electrode (GCE). The resulting sensor was successfully applied for the sensitive detection of paroxetine·HCl (PRX), a selective serotonin (5-HT) reuptake inhibitor (SSRIs), in its pharmaceutical formulations. The sensor was characterized morphologically using scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM) and electrochemical techniques such as differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The proposed sensor, poly (<span style="font-variant: small-caps;">dl</span>-met)/AuNPs-GCE, exhibited a linear response range from 5 × 10<sup>−11</sup> to 5 × 10<sup>−8</sup> M and from 5 × 10<sup>−8</sup> to 1 × 10<sup>−4</sup> M using DPV with lowest limit of detection (LOD = 1 × 10<sup>−11</sup> M) based on (S/N = 3). The poly (<span style="font-variant: small-caps;">dl</span>-met)/AuNPs-GCE sensor was successfully applied for PRX determination in three different pharmaceutical formulations with percent recoveries between 96.29% and 103.40% ± SD (±0.02 and ±0.58, respectively).Saedah R. Al-MhyawiRiham K. AhmedRasha M. El NasharMDPI AGarticleparoxetinepoly (<span style="font-variant: small-caps">dl</span>-methionine)electropolymerizationselective serotonin reuptake inhibitorvoltammetrygold nanoparticlesOrganic chemistryQD241-441ENPolymers, Vol 13, Iss 3981, p 3981 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	paroxetine poly (<span style="font-variant: small-caps">dl</span>-methionine) electropolymerization selective serotonin reuptake inhibitor voltammetry gold nanoparticles Organic chemistry QD241-441
spellingShingle	paroxetine poly (<span style="font-variant: small-caps">dl</span>-methionine) electropolymerization selective serotonin reuptake inhibitor voltammetry gold nanoparticles Organic chemistry QD241-441 Saedah R. Al-Mhyawi Riham K. Ahmed Rasha M. El Nashar Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine
description	This work demonstrates a facile electropolymerization of a <span style="font-variant: small-caps;">dl</span>-methionine (<span style="font-variant: small-caps;">dl</span>-met) conducting polymeric film on a gold nanoparticle (AuNPs)-modified glassy carbon electrode (GCE). The resulting sensor was successfully applied for the sensitive detection of paroxetine·HCl (PRX), a selective serotonin (5-HT) reuptake inhibitor (SSRIs), in its pharmaceutical formulations. The sensor was characterized morphologically using scanning electron microscopy (SEM) with energy dispersive X-ray spectroscopy (EDX) and atomic force microscopy (AFM) and electrochemical techniques such as differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV). The proposed sensor, poly (<span style="font-variant: small-caps;">dl</span>-met)/AuNPs-GCE, exhibited a linear response range from 5 × 10<sup>−11</sup> to 5 × 10<sup>−8</sup> M and from 5 × 10<sup>−8</sup> to 1 × 10<sup>−4</sup> M using DPV with lowest limit of detection (LOD = 1 × 10<sup>−11</sup> M) based on (S/N = 3). The poly (<span style="font-variant: small-caps;">dl</span>-met)/AuNPs-GCE sensor was successfully applied for PRX determination in three different pharmaceutical formulations with percent recoveries between 96.29% and 103.40% ± SD (±0.02 and ±0.58, respectively).
format	article
author	Saedah R. Al-Mhyawi Riham K. Ahmed Rasha M. El Nashar
author_facet	Saedah R. Al-Mhyawi Riham K. Ahmed Rasha M. El Nashar
author_sort	Saedah R. Al-Mhyawi
title	Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine
title_short	Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine
title_full	Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine
title_fullStr	Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine
title_full_unstemmed	Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine
title_sort	application of a conducting poly-methionine/gold nanoparticles-modified sensor for the electrochemical detection of paroxetine
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/855a04fe479c417cb769a073fa849f8c
work_keys_str_mv	AT saedahralmhyawi applicationofaconductingpolymethioninegoldnanoparticlesmodifiedsensorfortheelectrochemicaldetectionofparoxetine AT rihamkahmed applicationofaconductingpolymethioninegoldnanoparticlesmodifiedsensorfortheelectrochemicaldetectionofparoxetine AT rashamelnashar applicationofaconductingpolymethioninegoldnanoparticlesmodifiedsensorfortheelectrochemicaldetectionofparoxetine
_version_	1718410656621789184

Application of a Conducting Poly-Methionine/Gold Nanoparticles-Modified Sensor for the Electrochemical Detection of Paroxetine

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