Handgrip strength as a moderator of the influence of age on olfactory impairment in US adult population ≥ 40 years of age

Abstract The aim of this study was to determine whether handgrip strength attenuates the negative relationship between age and olfactory function in a representative US population sample 40 years old and over. A cross-sectional study was performed with 2861 adults from the US National Health and Nut...

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Autores principales:	Robinson Ramírez-Vélez, José Francisco López-Gil, Mikel López Sáez de Asteasu, Mikel Izquierdo, Antonio García-Hermoso
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/8561d6652b884dbea9e48174e3c936db
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spelling	oai:doaj.org-article:8561d6652b884dbea9e48174e3c936db2021-12-02T16:15:05ZHandgrip strength as a moderator of the influence of age on olfactory impairment in US adult population ≥ 40 years of age10.1038/s41598-021-93355-w2045-2322https://doaj.org/article/8561d6652b884dbea9e48174e3c936db2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-93355-whttps://doaj.org/toc/2045-2322Abstract The aim of this study was to determine whether handgrip strength attenuates the negative relationship between age and olfactory function in a representative US population sample 40 years old and over. A cross-sectional study was performed with 2861 adults from the US National Health and Nutrition Examination Survey NHANES (2013–2014). An 8-item odor identification test was applied to determine olfactory function. Muscle strength was determined through a handgrip dynamometer (defined as the sum of the largest handgrip strength reading from right and left hands). Moderation analysis was performed to test whether the association between age and olfactory impairment was moderated by handgrip strength. Moderation analysis highlighted two regions of significance: the first region was found at < 56.6 kg, indicating that the adverse influence of age on olfactory function may be greater for the participants in this area; the second region was found at ≥ 56.6 kg, indicating that the negative impact of age on olfactory function disappeared for adults who were above this estimate point. In conclusion, handgrip strength, a general indicator of muscle strength, moderates the relationship between age and olfactory ability in a US adult population aged 40 years and older. Our findings are clinically relevant, since they emphasize the importance of muscular fitness in adulthood and old age by diminishing the deleterious effect of aging on olfactory performance.Robinson Ramírez-VélezJosé Francisco López-GilMikel López Sáez de AsteasuMikel IzquierdoAntonio García-HermosoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Robinson Ramírez-Vélez José Francisco López-Gil Mikel López Sáez de Asteasu Mikel Izquierdo Antonio García-Hermoso Handgrip strength as a moderator of the influence of age on olfactory impairment in US adult population ≥ 40 years of age
description	Abstract The aim of this study was to determine whether handgrip strength attenuates the negative relationship between age and olfactory function in a representative US population sample 40 years old and over. A cross-sectional study was performed with 2861 adults from the US National Health and Nutrition Examination Survey NHANES (2013–2014). An 8-item odor identification test was applied to determine olfactory function. Muscle strength was determined through a handgrip dynamometer (defined as the sum of the largest handgrip strength reading from right and left hands). Moderation analysis was performed to test whether the association between age and olfactory impairment was moderated by handgrip strength. Moderation analysis highlighted two regions of significance: the first region was found at < 56.6 kg, indicating that the adverse influence of age on olfactory function may be greater for the participants in this area; the second region was found at ≥ 56.6 kg, indicating that the negative impact of age on olfactory function disappeared for adults who were above this estimate point. In conclusion, handgrip strength, a general indicator of muscle strength, moderates the relationship between age and olfactory ability in a US adult population aged 40 years and older. Our findings are clinically relevant, since they emphasize the importance of muscular fitness in adulthood and old age by diminishing the deleterious effect of aging on olfactory performance.
format	article
author	Robinson Ramírez-Vélez José Francisco López-Gil Mikel López Sáez de Asteasu Mikel Izquierdo Antonio García-Hermoso
author_facet	Robinson Ramírez-Vélez José Francisco López-Gil Mikel López Sáez de Asteasu Mikel Izquierdo Antonio García-Hermoso
author_sort	Robinson Ramírez-Vélez
title	Handgrip strength as a moderator of the influence of age on olfactory impairment in US adult population ≥ 40 years of age
title_short	Handgrip strength as a moderator of the influence of age on olfactory impairment in US adult population ≥ 40 years of age
title_full	Handgrip strength as a moderator of the influence of age on olfactory impairment in US adult population ≥ 40 years of age
title_fullStr	Handgrip strength as a moderator of the influence of age on olfactory impairment in US adult population ≥ 40 years of age
title_full_unstemmed	Handgrip strength as a moderator of the influence of age on olfactory impairment in US adult population ≥ 40 years of age
title_sort	handgrip strength as a moderator of the influence of age on olfactory impairment in us adult population ≥ 40 years of age
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/8561d6652b884dbea9e48174e3c936db
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Handgrip strength as a moderator of the influence of age on olfactory impairment in US adult population ≥ 40 years of age

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