DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load

Demethylation of the genome is found in cancer. Here, the authors show that genomic demethylation entails changes in promoter methylation and gene expression associated with immune escape and suggest that the epigenetic alterations may be an important determinant of responses to immunotherapy.

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Autores principales: Hyunchul Jung, Hong Sook Kim, Jeong Yeon Kim, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Manel Esteller, Se-Hoon Lee, Jung Kyoon Choi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/85658e71ba8442669c3d3515dd6416cb
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Sumario:Demethylation of the genome is found in cancer. Here, the authors show that genomic demethylation entails changes in promoter methylation and gene expression associated with immune escape and suggest that the epigenetic alterations may be an important determinant of responses to immunotherapy.