DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load

Demethylation of the genome is found in cancer. Here, the authors show that genomic demethylation entails changes in promoter methylation and gene expression associated with immune escape and suggest that the epigenetic alterations may be an important determinant of responses to immunotherapy.

Guardado en:

Detalles Bibliográficos
Autores principales:	Hyunchul Jung, Hong Sook Kim, Jeong Yeon Kim, Jong-Mu Sun, Jin Seok Ahn, Myung-Ju Ahn, Keunchil Park, Manel Esteller, Se-Hoon Lee, Jung Kyoon Choi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85658e71ba8442669c3d3515dd6416cb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:85658e71ba8442669c3d3515dd6416cb
record_format	dspace
spelling	oai:doaj.org-article:85658e71ba8442669c3d3515dd6416cb2021-12-02T14:40:18ZDNA methylation loss promotes immune evasion of tumours with high mutation and copy number load10.1038/s41467-019-12159-92041-1723https://doaj.org/article/85658e71ba8442669c3d3515dd6416cb2019-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12159-9https://doaj.org/toc/2041-1723Demethylation of the genome is found in cancer. Here, the authors show that genomic demethylation entails changes in promoter methylation and gene expression associated with immune escape and suggest that the epigenetic alterations may be an important determinant of responses to immunotherapy.Hyunchul JungHong Sook KimJeong Yeon KimJong-Mu SunJin Seok AhnMyung-Ju AhnKeunchil ParkManel EstellerSe-Hoon LeeJung Kyoon ChoiNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hyunchul Jung Hong Sook Kim Jeong Yeon Kim Jong-Mu Sun Jin Seok Ahn Myung-Ju Ahn Keunchil Park Manel Esteller Se-Hoon Lee Jung Kyoon Choi DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
description	Demethylation of the genome is found in cancer. Here, the authors show that genomic demethylation entails changes in promoter methylation and gene expression associated with immune escape and suggest that the epigenetic alterations may be an important determinant of responses to immunotherapy.
format	article
author	Hyunchul Jung Hong Sook Kim Jeong Yeon Kim Jong-Mu Sun Jin Seok Ahn Myung-Ju Ahn Keunchil Park Manel Esteller Se-Hoon Lee Jung Kyoon Choi
author_facet	Hyunchul Jung Hong Sook Kim Jeong Yeon Kim Jong-Mu Sun Jin Seok Ahn Myung-Ju Ahn Keunchil Park Manel Esteller Se-Hoon Lee Jung Kyoon Choi
author_sort	Hyunchul Jung
title	DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
title_short	DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
title_full	DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
title_fullStr	DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
title_full_unstemmed	DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load
title_sort	dna methylation loss promotes immune evasion of tumours with high mutation and copy number load
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/85658e71ba8442669c3d3515dd6416cb
work_keys_str_mv	AT hyunchuljung dnamethylationlosspromotesimmuneevasionoftumourswithhighmutationandcopynumberload AT hongsookkim dnamethylationlosspromotesimmuneevasionoftumourswithhighmutationandcopynumberload AT jeongyeonkim dnamethylationlosspromotesimmuneevasionoftumourswithhighmutationandcopynumberload AT jongmusun dnamethylationlosspromotesimmuneevasionoftumourswithhighmutationandcopynumberload AT jinseokahn dnamethylationlosspromotesimmuneevasionoftumourswithhighmutationandcopynumberload AT myungjuahn dnamethylationlosspromotesimmuneevasionoftumourswithhighmutationandcopynumberload AT keunchilpark dnamethylationlosspromotesimmuneevasionoftumourswithhighmutationandcopynumberload AT manelesteller dnamethylationlosspromotesimmuneevasionoftumourswithhighmutationandcopynumberload AT sehoonlee dnamethylationlosspromotesimmuneevasionoftumourswithhighmutationandcopynumberload AT jungkyoonchoi dnamethylationlosspromotesimmuneevasionoftumourswithhighmutationandcopynumberload
_version_	1718390367681773568

DNA methylation loss promotes immune evasion of tumours with high mutation and copy number load

Ejemplares similares