The New Human Babesia sp. FR1 Is a European Member of the Babesia sp. MO1 Clade

In Europe, Babesia divergens is responsible for most of the severe cases of human babesiosis. In the present study, we describe a case of babesiosis in a splenectomized patient in France and report a detailed molecular characterization of the etiological agent, named Babe...

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Autores principales:	Claire Bonsergent, Marie-Charlotte de Carné, Nathalie de la Cotte, François Moussel, Véronique Perronne, Laurence Malandrin
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	<i>Babesia divergens</i> <i>Babesia</i> sp. MO1 <i>Babesia capreoli</i> <i>rap-1a</i> <i>ama-1</i> phylogeny Medicine R
Acceso en línea:	https://doaj.org/article/8568d3dfddca41b2a141d1309f467d61
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id	oai:doaj.org-article:8568d3dfddca41b2a141d1309f467d61
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spelling	oai:doaj.org-article:8568d3dfddca41b2a141d1309f467d612021-11-25T18:38:14ZThe New Human <i>Babesia</i> sp. FR1 Is a European Member of the <i>Babesia</i> sp. MO1 Clade10.3390/pathogens101114332076-0817https://doaj.org/article/8568d3dfddca41b2a141d1309f467d612021-11-01T00:00:00Zhttps://www.mdpi.com/2076-0817/10/11/1433https://doaj.org/toc/2076-0817In Europe, <i>Babesia divergens</i> is responsible for most of the severe cases of human babesiosis. In the present study, we describe a case of babesiosis in a splenectomized patient in France and report a detailed molecular characterization of the etiological agent, named <i>Babesia</i> sp. FR1, as well as of closely related <i>Babesia divergens</i>, <i>Babesia capreoli</i> and <i>Babesia</i> sp. MO1-like parasites. The analysis of the conserved 18S rRNA gene was supplemented with the analysis of more discriminant markers involved in the red blood cell invasion process: <i>rap-1a</i> (rhoptry-associated-protein 1) and <i>ama-1</i> (apical-membrane-antigen 1). The <i>rap-1a</i> and <i>ama-1</i> phylogenetic analyses were congruent, placing <i>Babesia</i> sp. FR1, the new European etiological agent, in the American cluster of <i>Babesia</i> sp. MO1-like parasites. Based on two additional markers, our analysis confirms the clear separation of <i>B. divergens</i> and <i>B. capreoli</i>. <i>Babesia</i> sp. MO1-like parasites should also be considered as a separate species, with the rabbit as its natural host, differing from those of <i>B. divergens</i> (cattle) and <i>B. capreoli</i> (roe deer). The natural host of <i>Babesia</i> sp. FR1 remains to be discovered.Claire BonsergentMarie-Charlotte de CarnéNathalie de la CotteFrançois MousselVéronique PerronneLaurence MalandrinMDPI AGarticle<i>Babesia divergens</i><i>Babesia</i> sp. MO1<i>Babesia capreoli</i><i>rap-1a</i><i>ama-1</i>phylogenyMedicineRENPathogens, Vol 10, Iss 1433, p 1433 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	<i>Babesia divergens</i> <i>Babesia</i> sp. MO1 <i>Babesia capreoli</i> <i>rap-1a</i> <i>ama-1</i> phylogeny Medicine R
spellingShingle	<i>Babesia divergens</i> <i>Babesia</i> sp. MO1 <i>Babesia capreoli</i> <i>rap-1a</i> <i>ama-1</i> phylogeny Medicine R Claire Bonsergent Marie-Charlotte de Carné Nathalie de la Cotte François Moussel Véronique Perronne Laurence Malandrin The New Human <i>Babesia</i> sp. FR1 Is a European Member of the <i>Babesia</i> sp. MO1 Clade
description	In Europe, <i>Babesia divergens</i> is responsible for most of the severe cases of human babesiosis. In the present study, we describe a case of babesiosis in a splenectomized patient in France and report a detailed molecular characterization of the etiological agent, named <i>Babesia</i> sp. FR1, as well as of closely related <i>Babesia divergens</i>, <i>Babesia capreoli</i> and <i>Babesia</i> sp. MO1-like parasites. The analysis of the conserved 18S rRNA gene was supplemented with the analysis of more discriminant markers involved in the red blood cell invasion process: <i>rap-1a</i> (rhoptry-associated-protein 1) and <i>ama-1</i> (apical-membrane-antigen 1). The <i>rap-1a</i> and <i>ama-1</i> phylogenetic analyses were congruent, placing <i>Babesia</i> sp. FR1, the new European etiological agent, in the American cluster of <i>Babesia</i> sp. MO1-like parasites. Based on two additional markers, our analysis confirms the clear separation of <i>B. divergens</i> and <i>B. capreoli</i>. <i>Babesia</i> sp. MO1-like parasites should also be considered as a separate species, with the rabbit as its natural host, differing from those of <i>B. divergens</i> (cattle) and <i>B. capreoli</i> (roe deer). The natural host of <i>Babesia</i> sp. FR1 remains to be discovered.
format	article
author	Claire Bonsergent Marie-Charlotte de Carné Nathalie de la Cotte François Moussel Véronique Perronne Laurence Malandrin
author_facet	Claire Bonsergent Marie-Charlotte de Carné Nathalie de la Cotte François Moussel Véronique Perronne Laurence Malandrin
author_sort	Claire Bonsergent
title	The New Human <i>Babesia</i> sp. FR1 Is a European Member of the <i>Babesia</i> sp. MO1 Clade
title_short	The New Human <i>Babesia</i> sp. FR1 Is a European Member of the <i>Babesia</i> sp. MO1 Clade
title_full	The New Human <i>Babesia</i> sp. FR1 Is a European Member of the <i>Babesia</i> sp. MO1 Clade
title_fullStr	The New Human <i>Babesia</i> sp. FR1 Is a European Member of the <i>Babesia</i> sp. MO1 Clade
title_full_unstemmed	The New Human <i>Babesia</i> sp. FR1 Is a European Member of the <i>Babesia</i> sp. MO1 Clade
title_sort	new human <i>babesia</i> sp. fr1 is a european member of the <i>babesia</i> sp. mo1 clade
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/8568d3dfddca41b2a141d1309f467d61
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The New Human <i>Babesia</i> sp. FR1 Is a European Member of the <i>Babesia</i> sp. MO1 Clade

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