Update on the role of antipsychotics in the treatment of Tourette syndrome

Daniel Huys, Katja Hardenacke, Pia Poppe, Christina Bartsch, Burak Baskin, Jens KuhnDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, GermanyHead: Prof. Dr. Joachim Klosterk&ouml;tterAbstract: Tourette syndrome (TS) is a neuropsychiatric disorder with typical onset...

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Autores principales:	Huys D, Hardenacke K, Poppe P, Bartsch C, Baskin B, Kuhn J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/856b97fb9f904523b5cddfa2f702ed5a
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spelling	oai:doaj.org-article:856b97fb9f904523b5cddfa2f702ed5a2021-12-02T06:34:40ZUpdate on the role of antipsychotics in the treatment of Tourette syndrome1176-63281178-2021https://doaj.org/article/856b97fb9f904523b5cddfa2f702ed5a2012-03-01T00:00:00Zhttp://www.dovepress.com/update-on-the-role-of-antipsychotics-in-the-treatment-of-tourette-synd-a9453https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Daniel Huys, Katja Hardenacke, Pia Poppe, Christina Bartsch, Burak Baskin, Jens KuhnDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, GermanyHead: Prof. Dr. Joachim Klosterk&ouml;tterAbstract: Tourette syndrome (TS) is a neuropsychiatric disorder with typical onset in childhood and characterized by chronic occurrence of motor and vocal tics. The disorder can lead to serious impairments of both quality of life and psychosocial functioning, particularly for those individuals displaying complex tics. In such patients, drug treatment is recommended. The pathophysiology of TS is thought to involve a dysfunction of basal ganglia-related circuits and hyperactive dopaminergic innervations. Congruently, dopamine receptor antagonism of neuroleptics appears to be the most efficacious approach for pharmacological intervention. To assess the efficacy of the different neuroleptics available, a systematic, keyword-related search in PubMed (National Library of Medicine, Washington, DC) was undertaken. Much information on the use of antipsychotics in the treatment of TS is based on older data. Our objective was to give an update and therefore we focused on papers published in the last decade (between 2001 and 2011). Accordingly, the present review aims to summarize the current and evidence-based knowledge on the risk-benefit ratio of both first and second generation neuroleptics in TS.Keywords: Tourette, Tourette syndrome, neuroleptics, antipsychoticsHuys DHardenacke KPoppe PBartsch CBaskin BKuhn JDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2012, Iss default, Pp 95-104 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Huys D Hardenacke K Poppe P Bartsch C Baskin B Kuhn J Update on the role of antipsychotics in the treatment of Tourette syndrome
description	Daniel Huys, Katja Hardenacke, Pia Poppe, Christina Bartsch, Burak Baskin, Jens KuhnDepartment of Psychiatry and Psychotherapy, University of Cologne, Cologne, GermanyHead: Prof. Dr. Joachim Klosterk&ouml;tterAbstract: Tourette syndrome (TS) is a neuropsychiatric disorder with typical onset in childhood and characterized by chronic occurrence of motor and vocal tics. The disorder can lead to serious impairments of both quality of life and psychosocial functioning, particularly for those individuals displaying complex tics. In such patients, drug treatment is recommended. The pathophysiology of TS is thought to involve a dysfunction of basal ganglia-related circuits and hyperactive dopaminergic innervations. Congruently, dopamine receptor antagonism of neuroleptics appears to be the most efficacious approach for pharmacological intervention. To assess the efficacy of the different neuroleptics available, a systematic, keyword-related search in PubMed (National Library of Medicine, Washington, DC) was undertaken. Much information on the use of antipsychotics in the treatment of TS is based on older data. Our objective was to give an update and therefore we focused on papers published in the last decade (between 2001 and 2011). Accordingly, the present review aims to summarize the current and evidence-based knowledge on the risk-benefit ratio of both first and second generation neuroleptics in TS.Keywords: Tourette, Tourette syndrome, neuroleptics, antipsychotics
format	article
author	Huys D Hardenacke K Poppe P Bartsch C Baskin B Kuhn J
author_facet	Huys D Hardenacke K Poppe P Bartsch C Baskin B Kuhn J
author_sort	Huys D
title	Update on the role of antipsychotics in the treatment of Tourette syndrome
title_short	Update on the role of antipsychotics in the treatment of Tourette syndrome
title_full	Update on the role of antipsychotics in the treatment of Tourette syndrome
title_fullStr	Update on the role of antipsychotics in the treatment of Tourette syndrome
title_full_unstemmed	Update on the role of antipsychotics in the treatment of Tourette syndrome
title_sort	update on the role of antipsychotics in the treatment of tourette syndrome
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/856b97fb9f904523b5cddfa2f702ed5a
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Update on the role of antipsychotics in the treatment of Tourette syndrome

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