Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)

Succinate dehydrogenase inhibitor (SDHI) fungicides has been extensively used in agricultural production, which are not easily degrade in the environment and have various toxic effects on aquatic organisms. However, the toxic effects information to non-target organisms were mostly at the racemate le...

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Autores principales:	Bo Ren, Tingting Zhao, Yanhong Li, Hanlin Liang, Yuexing Zhao, Haiyue Chen, Li Li, Hongwu Liang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Penthiopyrad Enantioselectivity bioaccumulation Oxidative stress Mitochondrial function Apoptosis Zebrafish (Danio rerio) Environmental pollution TD172-193.5 Environmental sciences GE1-350
Acceso en línea:	https://doaj.org/article/856bdb75cc564e8d82f27290f482f1d6
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spelling	oai:doaj.org-article:856bdb75cc564e8d82f27290f482f1d62021-11-24T04:26:41ZEnantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)0147-651310.1016/j.ecoenv.2021.113010https://doaj.org/article/856bdb75cc564e8d82f27290f482f1d62021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0147651321011222https://doaj.org/toc/0147-6513Succinate dehydrogenase inhibitor (SDHI) fungicides has been extensively used in agricultural production, which are not easily degrade in the environment and have various toxic effects on aquatic organisms. However, the toxic effects information to non-target organisms were mostly at the racemate level, which were poorly understood at the enantiomers level. Thus, this study aimed to investigate the enantioselective bioaccumulation behavior and toxic effects of penthiopyrad in zebrafish. Significant enantioselective bioaccumulation was observed when exposed to penthiopyrad at two dose levels: S-(+)-penthiopyrad was preferentially accumulated. Moreover, S-(+)-penthiopyrad caused oxidative stress in zebrafish liver. The results of real-time RT-PCR analyses revealed that exposure to penthiopyrad also enantioselectivity interfered with the expression of mitochondrial respiratory complexes, mtDNA synthesis, lipid metabolism and apoptosis-related genes. S-(+)-penthiopyrad significantly decreased most of the expression of the above gene, which showed higher toxic effects. We inferred that the toxicity mechanism of penthiopyrad was caused by lipid metabolism disorder and mitochondrial dysfunction in zebrafish, and further leads to apoptosis even DNA damage. This study provides more accurate data to investigate the environmental impact of penthiopyrad at the enantiomer level.Bo RenTingting ZhaoYanhong LiHanlin LiangYuexing ZhaoHaiyue ChenLi LiHongwu LiangElsevierarticlePenthiopyradEnantioselectivity bioaccumulationOxidative stressMitochondrial functionApoptosisZebrafish (Danio rerio)Environmental pollutionTD172-193.5Environmental sciencesGE1-350ENEcotoxicology and Environmental Safety, Vol 228, Iss , Pp 113010- (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Penthiopyrad Enantioselectivity bioaccumulation Oxidative stress Mitochondrial function Apoptosis Zebrafish (Danio rerio) Environmental pollution TD172-193.5 Environmental sciences GE1-350
spellingShingle	Penthiopyrad Enantioselectivity bioaccumulation Oxidative stress Mitochondrial function Apoptosis Zebrafish (Danio rerio) Environmental pollution TD172-193.5 Environmental sciences GE1-350 Bo Ren Tingting Zhao Yanhong Li Hanlin Liang Yuexing Zhao Haiyue Chen Li Li Hongwu Liang Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)
description	Succinate dehydrogenase inhibitor (SDHI) fungicides has been extensively used in agricultural production, which are not easily degrade in the environment and have various toxic effects on aquatic organisms. However, the toxic effects information to non-target organisms were mostly at the racemate level, which were poorly understood at the enantiomers level. Thus, this study aimed to investigate the enantioselective bioaccumulation behavior and toxic effects of penthiopyrad in zebrafish. Significant enantioselective bioaccumulation was observed when exposed to penthiopyrad at two dose levels: S-(+)-penthiopyrad was preferentially accumulated. Moreover, S-(+)-penthiopyrad caused oxidative stress in zebrafish liver. The results of real-time RT-PCR analyses revealed that exposure to penthiopyrad also enantioselectivity interfered with the expression of mitochondrial respiratory complexes, mtDNA synthesis, lipid metabolism and apoptosis-related genes. S-(+)-penthiopyrad significantly decreased most of the expression of the above gene, which showed higher toxic effects. We inferred that the toxicity mechanism of penthiopyrad was caused by lipid metabolism disorder and mitochondrial dysfunction in zebrafish, and further leads to apoptosis even DNA damage. This study provides more accurate data to investigate the environmental impact of penthiopyrad at the enantiomer level.
format	article
author	Bo Ren Tingting Zhao Yanhong Li Hanlin Liang Yuexing Zhao Haiyue Chen Li Li Hongwu Liang
author_facet	Bo Ren Tingting Zhao Yanhong Li Hanlin Liang Yuexing Zhao Haiyue Chen Li Li Hongwu Liang
author_sort	Bo Ren
title	Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)
title_short	Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)
title_full	Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)
title_fullStr	Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)
title_full_unstemmed	Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)
title_sort	enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (danio rerio)
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/856bdb75cc564e8d82f27290f482f1d6
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Enantioselective bioaccumulation and toxicity of the novel chiral antifungal agrochemical penthiopyrad in zebrafish (Danio rerio)

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