Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study

Lina Ma,1,* Yanhong Xu,1,2,* Yaxin Zhang,1 Tong Ji,1 Yun Li1 1Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, People’s Republic of China; 2Department of Geriatrics, Miyun Teaching Hospital of C...

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Autores principales:	Ma L, Xu Y, Zhang Y, Ji T, Li Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	metabolic inflammatory syndrome adiponectin atherosclerosis type 2 diabetes obesity inflammation elderly patients Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/856eb1c6608a4e36a59c14bc9d6bcf3a
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spelling	oai:doaj.org-article:856eb1c6608a4e36a59c14bc9d6bcf3a2021-12-02T09:17:04ZLower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study1178-7007https://doaj.org/article/856eb1c6608a4e36a59c14bc9d6bcf3a2020-02-01T00:00:00Zhttps://www.dovepress.com/lower-levels-of-circulating-adiponectin-in-elderly-patients-with-metab-peer-reviewed-article-DMSOhttps://doaj.org/toc/1178-7007Lina Ma,1,* Yanhong Xu,1,2,* Yaxin Zhang,1 Tong Ji,1 Yun Li1 1Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, People’s Republic of China; 2Department of Geriatrics, Miyun Teaching Hospital of Capital Medical University, Beijing 101500, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lina MaDepartment of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, #45 Changchun Street, Xicheng District, Beijing 100053, People’s Republic of ChinaEmail malina0883@126.comBackground: Metabolic inflammation plays an important role in the pathogenesis of atherosclerosis, type 2 diabetes, non-alcoholic fatty liver disease, and obesity. The above metabolic disorders often coexist and are closely related with systemic low-grade inflammation. Metabolic inflammatory syndrome (MIS), a cluster of these four metabolic disorders, is a novel concept that is thought to be a better predictor of coronary heart disease than metabolic syndrome. Adiponectin is an adipokine that increases insulin sensitivity and antioxidation as well as has an anti-atherosclerosis effect. It is unclear whether adiponectin is associated with MIS. The objective of this study was to assess whether circulating adiponectin can be used as an indicator for MIS in elderly adults.Methods: A total of 136 elderly inpatients were divided into two groups: the MIS group and the non-MIS group. Characteristics, inflammatory markers, blood lipid metabolism, insulin resistance, and circulating adiponectin levels were assessed and compared between the two groups. Logistic regression analysis was used to explore the association between the associated factors and MIS.Results: MIS patients were more likely to have a higher body mass index, have a higher fasting blood glucose level, be smokers, have fundus arteriosclerosis, have lower levels of adiponectin (4044.90 ± 3906.82 ng/mL vs 8503.89 ± 3523.89 ng/mL, p < 0.001), and have higher levels of inflammation (white blood cell and C-reactive protein) than non-MIS patients. Multiple factor analysis showed that lower adiponectin levels (OR = 22.937, p < 0.001) were independently associated with MIS. Adiponectin levels were lower in the vascular disease (2673.29 ± 1930.05 ng/mL vs 7194.38 ± 4615.83 ng/mL, p = 0.001), atherosclerosis (2374.14 [1496.41– 4263.90] ng/mL vs 6037.48 [3865.61– 10,373.60] ng/mL, p < 0.001), and type 2 diabetes (2391.73 [1386.41– 4069.68] ng/mL vs 8916.03 [5801.14– 12,724.45] ng/mL, p < 0.001) subgroups than in the non-MIS group.Conclusion: Lower adiponectin levels in serum are associated with MIS. Low adiponectin may be used as a biomarker for atherosclerosis in patients with MIS.Keywords: metabolic inflammatory syndrome, adiponectin, atherosclerosis, type 2 diabetes, obesity, inflammation, elderly patientsMa LXu YZhang YJi TLi YDove Medical Pressarticlemetabolic inflammatory syndromeadiponectinatherosclerosistype 2 diabetesobesityinflammationelderly patientsSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 13, Pp 591-596 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	metabolic inflammatory syndrome adiponectin atherosclerosis type 2 diabetes obesity inflammation elderly patients Specialties of internal medicine RC581-951
spellingShingle	metabolic inflammatory syndrome adiponectin atherosclerosis type 2 diabetes obesity inflammation elderly patients Specialties of internal medicine RC581-951 Ma L Xu Y Zhang Y Ji T Li Y Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study
description	Lina Ma,1,* Yanhong Xu,1,2,* Yaxin Zhang,1 Tong Ji,1 Yun Li1 1Department of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, Beijing 100053, People’s Republic of China; 2Department of Geriatrics, Miyun Teaching Hospital of Capital Medical University, Beijing 101500, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lina MaDepartment of Geriatrics, Xuanwu Hospital, Capital Medical University, National Clinical Research Center for Geriatric Diseases, #45 Changchun Street, Xicheng District, Beijing 100053, People’s Republic of ChinaEmail malina0883@126.comBackground: Metabolic inflammation plays an important role in the pathogenesis of atherosclerosis, type 2 diabetes, non-alcoholic fatty liver disease, and obesity. The above metabolic disorders often coexist and are closely related with systemic low-grade inflammation. Metabolic inflammatory syndrome (MIS), a cluster of these four metabolic disorders, is a novel concept that is thought to be a better predictor of coronary heart disease than metabolic syndrome. Adiponectin is an adipokine that increases insulin sensitivity and antioxidation as well as has an anti-atherosclerosis effect. It is unclear whether adiponectin is associated with MIS. The objective of this study was to assess whether circulating adiponectin can be used as an indicator for MIS in elderly adults.Methods: A total of 136 elderly inpatients were divided into two groups: the MIS group and the non-MIS group. Characteristics, inflammatory markers, blood lipid metabolism, insulin resistance, and circulating adiponectin levels were assessed and compared between the two groups. Logistic regression analysis was used to explore the association between the associated factors and MIS.Results: MIS patients were more likely to have a higher body mass index, have a higher fasting blood glucose level, be smokers, have fundus arteriosclerosis, have lower levels of adiponectin (4044.90 ± 3906.82 ng/mL vs 8503.89 ± 3523.89 ng/mL, p < 0.001), and have higher levels of inflammation (white blood cell and C-reactive protein) than non-MIS patients. Multiple factor analysis showed that lower adiponectin levels (OR = 22.937, p < 0.001) were independently associated with MIS. Adiponectin levels were lower in the vascular disease (2673.29 ± 1930.05 ng/mL vs 7194.38 ± 4615.83 ng/mL, p = 0.001), atherosclerosis (2374.14 [1496.41– 4263.90] ng/mL vs 6037.48 [3865.61– 10,373.60] ng/mL, p < 0.001), and type 2 diabetes (2391.73 [1386.41– 4069.68] ng/mL vs 8916.03 [5801.14– 12,724.45] ng/mL, p < 0.001) subgroups than in the non-MIS group.Conclusion: Lower adiponectin levels in serum are associated with MIS. Low adiponectin may be used as a biomarker for atherosclerosis in patients with MIS.Keywords: metabolic inflammatory syndrome, adiponectin, atherosclerosis, type 2 diabetes, obesity, inflammation, elderly patients
format	article
author	Ma L Xu Y Zhang Y Ji T Li Y
author_facet	Ma L Xu Y Zhang Y Ji T Li Y
author_sort	Ma L
title	Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study
title_short	Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study
title_full	Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study
title_fullStr	Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study
title_full_unstemmed	Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study
title_sort	lower levels of circulating adiponectin in elderly patients with metabolic inflammatory syndrome: a cross-sectional study
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/856eb1c6608a4e36a59c14bc9d6bcf3a
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Lower Levels of Circulating Adiponectin in Elderly Patients with Metabolic Inflammatory Syndrome: A Cross-Sectional Study

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