Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics
The homeobox NKX2 family of transcriptional factors has been shown to regulate fundamental developmental processes. Here, the authors show that NKX2-3 is a bona fideoncogenic driver in marginal-zone B-cell lymphoma and that it promotes lymphomagenesis by shaping lymphocyte dynamics and promoting BCR...
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Nature Portfolio
2016
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oai:doaj.org-article:8577d51efbf14e6384756140937ba8722021-12-02T14:39:28ZHomeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics10.1038/ncomms118892041-1723https://doaj.org/article/8577d51efbf14e6384756140937ba8722016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11889https://doaj.org/toc/2041-1723The homeobox NKX2 family of transcriptional factors has been shown to regulate fundamental developmental processes. Here, the authors show that NKX2-3 is a bona fideoncogenic driver in marginal-zone B-cell lymphoma and that it promotes lymphomagenesis by shaping lymphocyte dynamics and promoting BCR signalling.Eloy F. RoblesMaria Mena-VarasLaura BarrioSara V. Merino-CortesPéter BaloghMing-Qing DuTakashi AkasakaAnton ParkerSergio RoaCarlos PanizoIdoia Martin-GuerreroReiner SiebertVictor SeguraXabier AgirreLaura Macri-PellizeriBeatriz AldazAmaia Vilas-ZornozaShaowei ZhangSarah MoodyMaria Jose CalasanzThomas TousseynCyril BroccardoPierre BroussetElena Campos-SanchezCesar CobaledaIsidro Sanchez-GarciaJose Luis Fernandez-LunaRicardo Garcia-MuñozEsther PenaBeatriz BellosilloAntonio SalarMaria Joao BaptistaJesús Maria Hernandez-RivasMarcos GonzalezMaria Jose TerolJoan ClimentAntonio FerrandezXavier SagaertAri M. MelnickFelipe ProsperDavid G. OscierYolanda R. CarrascoMartin J. S. DyerJose A. Martinez-ClimentNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016) |
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DOAJ |
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EN |
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Science Q |
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Science Q Eloy F. Robles Maria Mena-Varas Laura Barrio Sara V. Merino-Cortes Péter Balogh Ming-Qing Du Takashi Akasaka Anton Parker Sergio Roa Carlos Panizo Idoia Martin-Guerrero Reiner Siebert Victor Segura Xabier Agirre Laura Macri-Pellizeri Beatriz Aldaz Amaia Vilas-Zornoza Shaowei Zhang Sarah Moody Maria Jose Calasanz Thomas Tousseyn Cyril Broccardo Pierre Brousset Elena Campos-Sanchez Cesar Cobaleda Isidro Sanchez-Garcia Jose Luis Fernandez-Luna Ricardo Garcia-Muñoz Esther Pena Beatriz Bellosillo Antonio Salar Maria Joao Baptista Jesús Maria Hernandez-Rivas Marcos Gonzalez Maria Jose Terol Joan Climent Antonio Ferrandez Xavier Sagaert Ari M. Melnick Felipe Prosper David G. Oscier Yolanda R. Carrasco Martin J. S. Dyer Jose A. Martinez-Climent Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics |
| description |
The homeobox NKX2 family of transcriptional factors has been shown to regulate fundamental developmental processes. Here, the authors show that NKX2-3 is a bona fideoncogenic driver in marginal-zone B-cell lymphoma and that it promotes lymphomagenesis by shaping lymphocyte dynamics and promoting BCR signalling. |
| format |
article |
| author |
Eloy F. Robles Maria Mena-Varas Laura Barrio Sara V. Merino-Cortes Péter Balogh Ming-Qing Du Takashi Akasaka Anton Parker Sergio Roa Carlos Panizo Idoia Martin-Guerrero Reiner Siebert Victor Segura Xabier Agirre Laura Macri-Pellizeri Beatriz Aldaz Amaia Vilas-Zornoza Shaowei Zhang Sarah Moody Maria Jose Calasanz Thomas Tousseyn Cyril Broccardo Pierre Brousset Elena Campos-Sanchez Cesar Cobaleda Isidro Sanchez-Garcia Jose Luis Fernandez-Luna Ricardo Garcia-Muñoz Esther Pena Beatriz Bellosillo Antonio Salar Maria Joao Baptista Jesús Maria Hernandez-Rivas Marcos Gonzalez Maria Jose Terol Joan Climent Antonio Ferrandez Xavier Sagaert Ari M. Melnick Felipe Prosper David G. Oscier Yolanda R. Carrasco Martin J. S. Dyer Jose A. Martinez-Climent |
| author_facet |
Eloy F. Robles Maria Mena-Varas Laura Barrio Sara V. Merino-Cortes Péter Balogh Ming-Qing Du Takashi Akasaka Anton Parker Sergio Roa Carlos Panizo Idoia Martin-Guerrero Reiner Siebert Victor Segura Xabier Agirre Laura Macri-Pellizeri Beatriz Aldaz Amaia Vilas-Zornoza Shaowei Zhang Sarah Moody Maria Jose Calasanz Thomas Tousseyn Cyril Broccardo Pierre Brousset Elena Campos-Sanchez Cesar Cobaleda Isidro Sanchez-Garcia Jose Luis Fernandez-Luna Ricardo Garcia-Muñoz Esther Pena Beatriz Bellosillo Antonio Salar Maria Joao Baptista Jesús Maria Hernandez-Rivas Marcos Gonzalez Maria Jose Terol Joan Climent Antonio Ferrandez Xavier Sagaert Ari M. Melnick Felipe Prosper David G. Oscier Yolanda R. Carrasco Martin J. S. Dyer Jose A. Martinez-Climent |
| author_sort |
Eloy F. Robles |
| title |
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics |
| title_short |
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics |
| title_full |
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics |
| title_fullStr |
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics |
| title_full_unstemmed |
Homeobox NKX2-3 promotes marginal-zone lymphomagenesis by activating B-cell receptor signalling and shaping lymphocyte dynamics |
| title_sort |
homeobox nkx2-3 promotes marginal-zone lymphomagenesis by activating b-cell receptor signalling and shaping lymphocyte dynamics |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/8577d51efbf14e6384756140937ba872 |
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