Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast

Francisco G Ortega,1 Martín A Fernández-Baldo,2 Jorge G Fernández,2 María J Serrano,1 María I Sanz,2 Juan J Diaz-Mochón,1 José A Lorente,1 Julio Raba21GENYO, Centre for Genomics and Oncological Research: Pfizer-University...

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Autores principales:	Ortega FG, Fernández-Baldo MA, Fernández JG, Serrano MJ, Sanz MI, Diaz-Mochón JJ, Lorente JA, Raba J
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/85782512c78341fb8a556be431d7eb00
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spelling	oai:doaj.org-article:85782512c78341fb8a556be431d7eb002021-12-02T07:12:10ZStudy of antitumor activity in breast cell lines using silver nanoparticles produced by yeast1178-2013https://doaj.org/article/85782512c78341fb8a556be431d7eb002015-03-01T00:00:00Zhttp://www.dovepress.com/study-of-antitumor-activity-in-breast-cell-lines-using-silver-nanopart-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013 Francisco G Ortega,1 Martín A Fernández-Baldo,2 Jorge G Fernández,2 María J Serrano,1 María I Sanz,2 Juan J Diaz-Mochón,1 José A Lorente,1 Julio Raba21GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, PTS Granada, Avenida de Ilustración, Granada, Spain; 2INQUISAL, Departamento de Química, CONICET, Universidad Nacional de San Luis, San Luis, Argentina Abstract: In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction, and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast cells, which is due to the higher endocytic activity of tumor cells compared to normal cells. In this way, we demonstrate that biosynthesized Ag NPs can be an alternative for the treatment of tumors. Keywords: apoptosis, biosynthesized silver nanoparticles, breast cancer, microbiological synthesisOrtega FGFernández-Baldo MAFernández JGSerrano MJSanz MIDiaz-Mochón JJLorente JARaba JDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2015, Iss default, Pp 2021-2031 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Ortega FG Fernández-Baldo MA Fernández JG Serrano MJ Sanz MI Diaz-Mochón JJ Lorente JA Raba J Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
description	Francisco G Ortega,1 Martín A Fernández-Baldo,2 Jorge G Fernández,2 María J Serrano,1 María I Sanz,2 Juan J Diaz-Mochón,1 José A Lorente,1 Julio Raba21GENYO, Centre for Genomics and Oncological Research: Pfizer-University of Granada, Andalusian Regional Government, PTS Granada, Avenida de Ilustración, Granada, Spain; 2INQUISAL, Departamento de Química, CONICET, Universidad Nacional de San Luis, San Luis, Argentina Abstract: In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction, and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast cells, which is due to the higher endocytic activity of tumor cells compared to normal cells. In this way, we demonstrate that biosynthesized Ag NPs can be an alternative for the treatment of tumors. Keywords: apoptosis, biosynthesized silver nanoparticles, breast cancer, microbiological synthesis
format	article
author	Ortega FG Fernández-Baldo MA Fernández JG Serrano MJ Sanz MI Diaz-Mochón JJ Lorente JA Raba J
author_facet	Ortega FG Fernández-Baldo MA Fernández JG Serrano MJ Sanz MI Diaz-Mochón JJ Lorente JA Raba J
author_sort	Ortega FG
title	Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
title_short	Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
title_full	Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
title_fullStr	Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
title_full_unstemmed	Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
title_sort	study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/85782512c78341fb8a556be431d7eb00
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Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast

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