THE IMMUNE STATUS AND IFN GENE POLYMORPHISM AS PROGNOSTIC CRITERIA FOR THE EFFECTIVENESS OF HEPATITIS C TREATMENT IN HIV-INFECTED PATIENTS

Abstract. The aim of the study was to evaluate the role of immune status and IFN gene polymorphism in the prediction of the efficacy of chronic hepatitis C antiviral therapy in HIV-infected patients. Eighty HIV-infected patients with hepatitis C were recruited. Antiviral therapy included pegylated i...

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Autores principales:	E. S. Kovaleva, B. Yu. Gumilevsky
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2014
Materias:	hiv-infection viral hepatitis c antiviral therapy cytokines immunogenetic criteria Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/8579c2cb73aa4d6b9dce47846610f443
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spelling	oai:doaj.org-article:8579c2cb73aa4d6b9dce47846610f4432021-11-22T07:09:46ZTHE IMMUNE STATUS AND IFN GENE POLYMORPHISM AS PROGNOSTIC CRITERIA FOR THE EFFECTIVENESS OF HEPATITIS C TREATMENT IN HIV-INFECTED PATIENTS2220-76192313-739810.15789/2220-7619-2013-1-83-88https://doaj.org/article/8579c2cb73aa4d6b9dce47846610f4432014-07-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/131https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Abstract. The aim of the study was to evaluate the role of immune status and IFN gene polymorphism in the prediction of the efficacy of chronic hepatitis C antiviral therapy in HIV-infected patients. Eighty HIV-infected patients with hepatitis C were recruited. Antiviral therapy included pegylated interferon-α and ribavirin. Flow cytometry was used to test the immune status; polymerase chain reaction method was used for the IFN gene polymorphisms determination. It was found the significant differences in the immune status and allelic variants combinations of the genes responsible for the formation of an adequate immune and antiviral responses in groups of patients with different response to treatment of hepatitis C. Herewith the effectiveness of hepatitis C treatment in HIV-infected patients is associated with the activation of T-cell immunity. Polymorphisms of interferon gene with other prognostic factors, make it possible to better define the disease prognosis and the treatment efficacy.E. S. KovalevaB. Yu. GumilevskySankt-Peterburg : NIIÈM imeni Pasteraarticlehiv-infectionviral hepatitis cantiviral therapycytokinesimmunogenetic criteriaInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 3, Iss 1, Pp 83-88 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	hiv-infection viral hepatitis c antiviral therapy cytokines immunogenetic criteria Infectious and parasitic diseases RC109-216
spellingShingle	hiv-infection viral hepatitis c antiviral therapy cytokines immunogenetic criteria Infectious and parasitic diseases RC109-216 E. S. Kovaleva B. Yu. Gumilevsky THE IMMUNE STATUS AND IFN GENE POLYMORPHISM AS PROGNOSTIC CRITERIA FOR THE EFFECTIVENESS OF HEPATITIS C TREATMENT IN HIV-INFECTED PATIENTS
description	Abstract. The aim of the study was to evaluate the role of immune status and IFN gene polymorphism in the prediction of the efficacy of chronic hepatitis C antiviral therapy in HIV-infected patients. Eighty HIV-infected patients with hepatitis C were recruited. Antiviral therapy included pegylated interferon-α and ribavirin. Flow cytometry was used to test the immune status; polymerase chain reaction method was used for the IFN gene polymorphisms determination. It was found the significant differences in the immune status and allelic variants combinations of the genes responsible for the formation of an adequate immune and antiviral responses in groups of patients with different response to treatment of hepatitis C. Herewith the effectiveness of hepatitis C treatment in HIV-infected patients is associated with the activation of T-cell immunity. Polymorphisms of interferon gene with other prognostic factors, make it possible to better define the disease prognosis and the treatment efficacy.
format	article
author	E. S. Kovaleva B. Yu. Gumilevsky
author_facet	E. S. Kovaleva B. Yu. Gumilevsky
author_sort	E. S. Kovaleva
title	THE IMMUNE STATUS AND IFN GENE POLYMORPHISM AS PROGNOSTIC CRITERIA FOR THE EFFECTIVENESS OF HEPATITIS C TREATMENT IN HIV-INFECTED PATIENTS
title_short	THE IMMUNE STATUS AND IFN GENE POLYMORPHISM AS PROGNOSTIC CRITERIA FOR THE EFFECTIVENESS OF HEPATITIS C TREATMENT IN HIV-INFECTED PATIENTS
title_full	THE IMMUNE STATUS AND IFN GENE POLYMORPHISM AS PROGNOSTIC CRITERIA FOR THE EFFECTIVENESS OF HEPATITIS C TREATMENT IN HIV-INFECTED PATIENTS
title_fullStr	THE IMMUNE STATUS AND IFN GENE POLYMORPHISM AS PROGNOSTIC CRITERIA FOR THE EFFECTIVENESS OF HEPATITIS C TREATMENT IN HIV-INFECTED PATIENTS
title_full_unstemmed	THE IMMUNE STATUS AND IFN GENE POLYMORPHISM AS PROGNOSTIC CRITERIA FOR THE EFFECTIVENESS OF HEPATITIS C TREATMENT IN HIV-INFECTED PATIENTS
title_sort	immune status and ifn gene polymorphism as prognostic criteria for the effectiveness of hepatitis c treatment in hiv-infected patients
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2014
url	https://doaj.org/article/8579c2cb73aa4d6b9dce47846610f443
work_keys_str_mv	AT eskovaleva theimmunestatusandifngenepolymorphismasprognosticcriteriafortheeffectivenessofhepatitisctreatmentinhivinfectedpatients AT byugumilevsky theimmunestatusandifngenepolymorphismasprognosticcriteriafortheeffectivenessofhepatitisctreatmentinhivinfectedpatients AT eskovaleva immunestatusandifngenepolymorphismasprognosticcriteriafortheeffectivenessofhepatitisctreatmentinhivinfectedpatients AT byugumilevsky immunestatusandifngenepolymorphismasprognosticcriteriafortheeffectivenessofhepatitisctreatmentinhivinfectedpatients
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THE IMMUNE STATUS AND IFN GENE POLYMORPHISM AS PROGNOSTIC CRITERIA FOR THE EFFECTIVENESS OF HEPATITIS C TREATMENT IN HIV-INFECTED PATIENTS

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