Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer

Abstract New therapies are an urgent medical need in all breast cancer subgroups. Metabotropic glutamate receptor 1 (mGluR1) is suggested as a potential new molecular target. We examined the prevalence mGluR1 expression in different clinically relevant breast cancer subgroups and determined its asso...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Anna E. M. Bastiaansen, A. Mieke Timmermans, Marcel Smid, Carolien H. M. van Deurzen, Esther S. P. Hulsenboom, Wendy J. C. Prager-van der Smissen, Renée Foekens, Anita M. A. C. Trapman-Jansen, Peter A. E. Sillevis Smitt, Theo M. Luider, John W. M. Martens, Martijn M. vanDuijn
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/857bf571bd7b4be593d8884fd1a9208e
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:857bf571bd7b4be593d8884fd1a9208e
record_format	dspace
spelling	oai:doaj.org-article:857bf571bd7b4be593d8884fd1a9208e2021-12-02T13:58:25ZMetabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer10.1038/s41598-020-79248-42045-2322https://doaj.org/article/857bf571bd7b4be593d8884fd1a9208e2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-79248-4https://doaj.org/toc/2045-2322Abstract New therapies are an urgent medical need in all breast cancer subgroups. Metabotropic glutamate receptor 1 (mGluR1) is suggested as a potential new molecular target. We examined the prevalence mGluR1 expression in different clinically relevant breast cancer subgroups and determined its association with prognosis. In this retrospective cohort, 394 consecutive primary breast cancer tissues were incorporated into a tissue microarray and immunohistochemically stained for mGluR1. The prevalence of mGluR1 protein expression in different breast cancer subgroups was evaluated and correlated with metastasis-free survival (MFS) and overall survival (OS). In total, 56% (n = 219) breast cancer tissues had mGluR1 expression. In estrogen receptor (ER)-negative tumors, 31% (n = 18/58) had mGluR1 expression that was significantly associated with MFS (HR 5.00, 95% CI 1.03–24.35, p = 0.046) in multivariate analysis, independently from other prognostic factors. Of the 44 triple-negative breast cancer (TNBC), 25% (n = 11) expressed mGluR1. mGluR1 expression in TNBC was significantly associated with shorter MFS (HR 8.60, 95% CI 1.06–20.39, p = 0.044) and with poor OS (HR 16.07, 95% CI 1.16–223.10, p = 0.039). In conclusion, mGluR1 is frequently expressed in breast cancer. In ER-negative breast cancer and in TNBC mGluR1 protein expression is an unfavorable prognostic marker. This study provides rationale to explore mGluR1 as a novel target for breast cancer treatment, especially for the more aggressive TNBC.Anna E. M. BastiaansenA. Mieke TimmermansMarcel SmidCarolien H. M. van DeurzenEsther S. P. HulsenboomWendy J. C. Prager-van der SmissenRenée FoekensAnita M. A. C. Trapman-JansenPeter A. E. Sillevis SmittTheo M. LuiderJohn W. M. MartensMartijn M. vanDuijnNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Anna E. M. Bastiaansen A. Mieke Timmermans Marcel Smid Carolien H. M. van Deurzen Esther S. P. Hulsenboom Wendy J. C. Prager-van der Smissen Renée Foekens Anita M. A. C. Trapman-Jansen Peter A. E. Sillevis Smitt Theo M. Luider John W. M. Martens Martijn M. vanDuijn Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer
description	Abstract New therapies are an urgent medical need in all breast cancer subgroups. Metabotropic glutamate receptor 1 (mGluR1) is suggested as a potential new molecular target. We examined the prevalence mGluR1 expression in different clinically relevant breast cancer subgroups and determined its association with prognosis. In this retrospective cohort, 394 consecutive primary breast cancer tissues were incorporated into a tissue microarray and immunohistochemically stained for mGluR1. The prevalence of mGluR1 protein expression in different breast cancer subgroups was evaluated and correlated with metastasis-free survival (MFS) and overall survival (OS). In total, 56% (n = 219) breast cancer tissues had mGluR1 expression. In estrogen receptor (ER)-negative tumors, 31% (n = 18/58) had mGluR1 expression that was significantly associated with MFS (HR 5.00, 95% CI 1.03–24.35, p = 0.046) in multivariate analysis, independently from other prognostic factors. Of the 44 triple-negative breast cancer (TNBC), 25% (n = 11) expressed mGluR1. mGluR1 expression in TNBC was significantly associated with shorter MFS (HR 8.60, 95% CI 1.06–20.39, p = 0.044) and with poor OS (HR 16.07, 95% CI 1.16–223.10, p = 0.039). In conclusion, mGluR1 is frequently expressed in breast cancer. In ER-negative breast cancer and in TNBC mGluR1 protein expression is an unfavorable prognostic marker. This study provides rationale to explore mGluR1 as a novel target for breast cancer treatment, especially for the more aggressive TNBC.
format	article
author	Anna E. M. Bastiaansen A. Mieke Timmermans Marcel Smid Carolien H. M. van Deurzen Esther S. P. Hulsenboom Wendy J. C. Prager-van der Smissen Renée Foekens Anita M. A. C. Trapman-Jansen Peter A. E. Sillevis Smitt Theo M. Luider John W. M. Martens Martijn M. vanDuijn
author_facet	Anna E. M. Bastiaansen A. Mieke Timmermans Marcel Smid Carolien H. M. van Deurzen Esther S. P. Hulsenboom Wendy J. C. Prager-van der Smissen Renée Foekens Anita M. A. C. Trapman-Jansen Peter A. E. Sillevis Smitt Theo M. Luider John W. M. Martens Martijn M. vanDuijn
author_sort	Anna E. M. Bastiaansen
title	Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer
title_short	Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer
title_full	Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer
title_fullStr	Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer
title_full_unstemmed	Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer
title_sort	metabotropic glutamate receptor 1 is associated with unfavorable prognosis in er-negative and triple-negative breast cancer
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/857bf571bd7b4be593d8884fd1a9208e
work_keys_str_mv	AT annaembastiaansen metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT amieketimmermans metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT marcelsmid metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT carolienhmvandeurzen metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT esthersphulsenboom metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT wendyjcpragervandersmissen metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT reneefoekens metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT anitamactrapmanjansen metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT peteraesillevissmitt metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT theomluider metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT johnwmmartens metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer AT martijnmvanduijn metabotropicglutamatereceptor1isassociatedwithunfavorableprognosisinernegativeandtriplenegativebreastcancer
_version_	1718392210554093568

Metabotropic glutamate receptor 1 is associated with unfavorable prognosis in ER-negative and triple-negative breast cancer

Ejemplares similares