External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.

<h4>Background</h4>Priapism impairs quality of life and has a predilection for males with sickle cell disease (SCD). The Priapism Impact Profile (PIP) is a novel 12-item instrument designed to measure general health-related impact of priapism. The aim of the study was to evaluate the val...

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Autores principales:	Belinda F Morrison, Wendy Madden, Monika Asnani, Ayodeji Sotimehin, Uzoma Anele, Yuezhou Jing, Bruce J Trock, Arthur L Burnett
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/857e30555a304e03b4dbdccb179017b8
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spelling	oai:doaj.org-article:857e30555a304e03b4dbdccb179017b82021-12-02T20:13:41ZExternal validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.1932-620310.1371/journal.pone.0258560https://doaj.org/article/857e30555a304e03b4dbdccb179017b82021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0258560https://doaj.org/toc/1932-6203<h4>Background</h4>Priapism impairs quality of life and has a predilection for males with sickle cell disease (SCD). The Priapism Impact Profile (PIP) is a novel 12-item instrument designed to measure general health-related impact of priapism. The aim of the study was to evaluate the validity and reliability of the PIP in a Jamaican cohort of SCD patients experiencing priapism.<h4>Methods</h4>One hundred SCD patients with a history of priapism were recruited from a sickle cell clinic in Kingston, Jamaica and administered the PIP questionnaire. Patients rated each item of the PIP for clarity and importance. Statistical testing was employed to evaluate the psychometric performance of the PIP. Content validation was assessed based on patient descriptive rating of the items based on clarity, and importance and criterion-oriented validity were assessed by evaluating the PIP's ability to distinguish between patient subgroups. Test-retest repeatability was assessed in 20 of the 100 patients.<h4>Results</h4>Patients were stratified into active (54) and remission (46) priapism groups based on their experience of priapism within the past year. Patients in the active priapism group were younger (p = 0.011), had a shorter duration of disease (p = 0.023), and had more frequent priapism episodes (p = 0.036) than the remission group. PIP questionnaire scores differed significantly with respect to priapism activity (p < 0.001) and prevalence of erectile dysfunction (p < 0.05) but not by priapism severity (p = 0.62). The PIP questionnaire had good content validity, with questions rated as having medium or high clarity and importance by an average of 82.8% and 69.2% of patients, respectively.<h4>Conclusion</h4>The PIP questionnaire was successfully validated in a Jamaican cohort of SCD patients and adequately discriminated patients with active priapism from those in remission. The instrument may be utilized in routine clinical management of patients with SCD-associated priapism. Further clinical investigations are warranted in other populations.Belinda F MorrisonWendy MaddenMonika AsnaniAyodeji SotimehinUzoma AneleYuezhou JingBruce J TrockArthur L BurnettPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 10, p e0258560 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Belinda F Morrison Wendy Madden Monika Asnani Ayodeji Sotimehin Uzoma Anele Yuezhou Jing Bruce J Trock Arthur L Burnett External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.
description	<h4>Background</h4>Priapism impairs quality of life and has a predilection for males with sickle cell disease (SCD). The Priapism Impact Profile (PIP) is a novel 12-item instrument designed to measure general health-related impact of priapism. The aim of the study was to evaluate the validity and reliability of the PIP in a Jamaican cohort of SCD patients experiencing priapism.<h4>Methods</h4>One hundred SCD patients with a history of priapism were recruited from a sickle cell clinic in Kingston, Jamaica and administered the PIP questionnaire. Patients rated each item of the PIP for clarity and importance. Statistical testing was employed to evaluate the psychometric performance of the PIP. Content validation was assessed based on patient descriptive rating of the items based on clarity, and importance and criterion-oriented validity were assessed by evaluating the PIP's ability to distinguish between patient subgroups. Test-retest repeatability was assessed in 20 of the 100 patients.<h4>Results</h4>Patients were stratified into active (54) and remission (46) priapism groups based on their experience of priapism within the past year. Patients in the active priapism group were younger (p = 0.011), had a shorter duration of disease (p = 0.023), and had more frequent priapism episodes (p = 0.036) than the remission group. PIP questionnaire scores differed significantly with respect to priapism activity (p < 0.001) and prevalence of erectile dysfunction (p < 0.05) but not by priapism severity (p = 0.62). The PIP questionnaire had good content validity, with questions rated as having medium or high clarity and importance by an average of 82.8% and 69.2% of patients, respectively.<h4>Conclusion</h4>The PIP questionnaire was successfully validated in a Jamaican cohort of SCD patients and adequately discriminated patients with active priapism from those in remission. The instrument may be utilized in routine clinical management of patients with SCD-associated priapism. Further clinical investigations are warranted in other populations.
format	article
author	Belinda F Morrison Wendy Madden Monika Asnani Ayodeji Sotimehin Uzoma Anele Yuezhou Jing Bruce J Trock Arthur L Burnett
author_facet	Belinda F Morrison Wendy Madden Monika Asnani Ayodeji Sotimehin Uzoma Anele Yuezhou Jing Bruce J Trock Arthur L Burnett
author_sort	Belinda F Morrison
title	External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.
title_short	External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.
title_full	External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.
title_fullStr	External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.
title_full_unstemmed	External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.
title_sort	external validation of the priapism impact profile in a jamaican cohort of patients with sickle cell disease.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/857e30555a304e03b4dbdccb179017b8
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External validation of the priapism impact profile in a Jamaican cohort of patients with sickle cell disease.

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