Phospholipid Phosphatase 4 as a Driver of Malignant Glioma and Pancreatic Adenocarcinoma

Glioma and pancreatic cancer are tumors with a high degree of malignancy, morbidity, and mortality. The present study explored possible molecular mechanisms and potential diagnostic and prognostic biomarker-PLPP4 of glioma and PAAD. PLPP4 is differentially elevated in glioma and PAAD tissues. Statis...

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Autores principales:	Wenxiu Tian, Ping Wang, Zhimei Wang, Huimin Qi, Junhong Dong, Hongmei Wang
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	phospholipid phosphatase 4 proliferation tumorigenesis glioma pancreatic adenocarcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/857e7a762eef4848a925ea2efd3625a7
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spelling	oai:doaj.org-article:857e7a762eef4848a925ea2efd3625a72021-12-01T18:23:57ZPhospholipid Phosphatase 4 as a Driver of Malignant Glioma and Pancreatic Adenocarcinoma2234-943X10.3389/fonc.2021.790676https://doaj.org/article/857e7a762eef4848a925ea2efd3625a72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.790676/fullhttps://doaj.org/toc/2234-943XGlioma and pancreatic cancer are tumors with a high degree of malignancy, morbidity, and mortality. The present study explored possible molecular mechanisms and potential diagnostic and prognostic biomarker-PLPP4 of glioma and PAAD. PLPP4 is differentially elevated in glioma and PAAD tissues. Statistical analysis from TCGA demonstrated that high expression of PLPP4 significantly and positively correlated with clinicopathological features, including pathological grade and poor overall survival in glioma and PAAD patients. Following this, the methylation levels of PLPP4 also affected overall survival in clinical tissue samples. Silencing PLPP4 inhibited proliferation, invasion, and migration in LN229 cells and PANC-1 cells. Moreover, the combination of multiple proteins for the prognosis prediction of glioma and PAAD was evaluated. These results were conducted to elaborate on the potential roles of the biomarker-PLPP4 in clonability and invasion of glioma and PAAD cells.Wenxiu TianWenxiu TianPing WangZhimei WangHuimin QiJunhong DongHongmei WangFrontiers Media S.A.articlephospholipid phosphatase 4proliferationtumorigenesisgliomapancreatic adenocarcinomaNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	phospholipid phosphatase 4 proliferation tumorigenesis glioma pancreatic adenocarcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	phospholipid phosphatase 4 proliferation tumorigenesis glioma pancreatic adenocarcinoma Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Wenxiu Tian Wenxiu Tian Ping Wang Zhimei Wang Huimin Qi Junhong Dong Hongmei Wang Phospholipid Phosphatase 4 as a Driver of Malignant Glioma and Pancreatic Adenocarcinoma
description	Glioma and pancreatic cancer are tumors with a high degree of malignancy, morbidity, and mortality. The present study explored possible molecular mechanisms and potential diagnostic and prognostic biomarker-PLPP4 of glioma and PAAD. PLPP4 is differentially elevated in glioma and PAAD tissues. Statistical analysis from TCGA demonstrated that high expression of PLPP4 significantly and positively correlated with clinicopathological features, including pathological grade and poor overall survival in glioma and PAAD patients. Following this, the methylation levels of PLPP4 also affected overall survival in clinical tissue samples. Silencing PLPP4 inhibited proliferation, invasion, and migration in LN229 cells and PANC-1 cells. Moreover, the combination of multiple proteins for the prognosis prediction of glioma and PAAD was evaluated. These results were conducted to elaborate on the potential roles of the biomarker-PLPP4 in clonability and invasion of glioma and PAAD cells.
format	article
author	Wenxiu Tian Wenxiu Tian Ping Wang Zhimei Wang Huimin Qi Junhong Dong Hongmei Wang
author_facet	Wenxiu Tian Wenxiu Tian Ping Wang Zhimei Wang Huimin Qi Junhong Dong Hongmei Wang
author_sort	Wenxiu Tian
title	Phospholipid Phosphatase 4 as a Driver of Malignant Glioma and Pancreatic Adenocarcinoma
title_short	Phospholipid Phosphatase 4 as a Driver of Malignant Glioma and Pancreatic Adenocarcinoma
title_full	Phospholipid Phosphatase 4 as a Driver of Malignant Glioma and Pancreatic Adenocarcinoma
title_fullStr	Phospholipid Phosphatase 4 as a Driver of Malignant Glioma and Pancreatic Adenocarcinoma
title_full_unstemmed	Phospholipid Phosphatase 4 as a Driver of Malignant Glioma and Pancreatic Adenocarcinoma
title_sort	phospholipid phosphatase 4 as a driver of malignant glioma and pancreatic adenocarcinoma
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/857e7a762eef4848a925ea2efd3625a7
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Phospholipid Phosphatase 4 as a Driver of Malignant Glioma and Pancreatic Adenocarcinoma

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