MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications

Wound vitality demonstration is one of the most challenging fields in forensic pathology. In recent years, researchers focused on the application of histological and immunohistochemical staining in this sphere of study. It is based on the detection of inflammation, red cell infiltration, and tissue...

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Autores principales:	Alice Chiara Manetti, Aniello Maiese, Arianna Baronti, Eleonora Mezzetti, Paola Frati, Vittorio Fineschi, Emanuela Turillazzi
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	miRNAs lesion vitality wound forensic genetic Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/858117b985644cc59fea078db669c8fd
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spelling	oai:doaj.org-article:858117b985644cc59fea078db669c8fd2021-11-25T16:51:32ZMiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications10.3390/biomedicines91117312227-9059https://doaj.org/article/858117b985644cc59fea078db669c8fd2021-11-01T00:00:00Zhttps://www.mdpi.com/2227-9059/9/11/1731https://doaj.org/toc/2227-9059Wound vitality demonstration is one of the most challenging fields in forensic pathology. In recent years, researchers focused on the application of histological and immunohistochemical staining in this sphere of study. It is based on the detection of inflammation, red cell infiltration, and tissue alterations at the histological examination, all of which are supposedly present in antemortem rather than post-mortem wounds. Nevertheless, some doubts about the reliability of those markers have arisen. Furthermore, the lack of a standardized protocol and the operator dependency of this approach make the proper interpretation of its results difficult. Moreover, a differential miRNAs expression has been demonstrated in antemortem and post-mortem wounds. Herein, a systematic review concerning the current knowledge about the use of miRNAs in lesion vitality evaluation is carried out, to encourage researchers to deepen this peculiar study area. A compendium about the potential miRNAs that may be further investigated as vitality markers is also provided. The aim is to collect all available data about this topic to direct further studies on this field and highlight the future applications of miRNAs in forensic pathology. We found 20 articles and a total of 51 miRNAs that are involved in inflammation and wound healing. Further studies are certainly needed to deepen the role of miRNAs in inflammatory processes in lesioned skin and to evaluate their reliability in distinguishing between antemortem and post-mortem lesions.Alice Chiara ManettiAniello MaieseArianna BarontiEleonora MezzettiPaola FratiVittorio FineschiEmanuela TurillazziMDPI AGarticlemiRNAslesion vitalitywound forensicgeneticBiology (General)QH301-705.5ENBiomedicines, Vol 9, Iss 1731, p 1731 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	miRNAs lesion vitality wound forensic genetic Biology (General) QH301-705.5
spellingShingle	miRNAs lesion vitality wound forensic genetic Biology (General) QH301-705.5 Alice Chiara Manetti Aniello Maiese Arianna Baronti Eleonora Mezzetti Paola Frati Vittorio Fineschi Emanuela Turillazzi MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications
description	Wound vitality demonstration is one of the most challenging fields in forensic pathology. In recent years, researchers focused on the application of histological and immunohistochemical staining in this sphere of study. It is based on the detection of inflammation, red cell infiltration, and tissue alterations at the histological examination, all of which are supposedly present in antemortem rather than post-mortem wounds. Nevertheless, some doubts about the reliability of those markers have arisen. Furthermore, the lack of a standardized protocol and the operator dependency of this approach make the proper interpretation of its results difficult. Moreover, a differential miRNAs expression has been demonstrated in antemortem and post-mortem wounds. Herein, a systematic review concerning the current knowledge about the use of miRNAs in lesion vitality evaluation is carried out, to encourage researchers to deepen this peculiar study area. A compendium about the potential miRNAs that may be further investigated as vitality markers is also provided. The aim is to collect all available data about this topic to direct further studies on this field and highlight the future applications of miRNAs in forensic pathology. We found 20 articles and a total of 51 miRNAs that are involved in inflammation and wound healing. Further studies are certainly needed to deepen the role of miRNAs in inflammatory processes in lesioned skin and to evaluate their reliability in distinguishing between antemortem and post-mortem lesions.
format	article
author	Alice Chiara Manetti Aniello Maiese Arianna Baronti Eleonora Mezzetti Paola Frati Vittorio Fineschi Emanuela Turillazzi
author_facet	Alice Chiara Manetti Aniello Maiese Arianna Baronti Eleonora Mezzetti Paola Frati Vittorio Fineschi Emanuela Turillazzi
author_sort	Alice Chiara Manetti
title	MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications
title_short	MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications
title_full	MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications
title_fullStr	MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications
title_full_unstemmed	MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications
title_sort	mirnas as new tools in lesion vitality evaluation: a systematic review and their forensic applications
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/858117b985644cc59fea078db669c8fd
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MiRNAs as New Tools in Lesion Vitality Evaluation: A Systematic Review and Their Forensic Applications

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