Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease.
<h4>Objective</h4>Impaired cerebral vasomotor reactivity (VMR) and flow-mediated dilation (FMD) were found in selected subgroups of type 2 diabetes mellitus (T2DM) patients with long-term disease. Our study aimed to evaluate cerebral hemodynamics, systemic endothelial function and sympat...
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2013
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oai:doaj.org-article:85850b54969d4ff59e961089835429752021-11-18T08:39:38ZCerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease.1932-620310.1371/journal.pone.0083287https://doaj.org/article/85850b54969d4ff59e961089835429752013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24391751/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Objective</h4>Impaired cerebral vasomotor reactivity (VMR) and flow-mediated dilation (FMD) were found in selected subgroups of type 2 diabetes mellitus (T2DM) patients with long-term disease. Our study aimed to evaluate cerebral hemodynamics, systemic endothelial function and sympatho-vagal balance in a selected population of well-controlled T2DM patients with short-term disease and without cardiac autonomic neuropathy (CAN).<h4>Research design and methods</h4>Twenty-six T2DM patients with short-term (4.40±4.80 years) and well-controlled (HbA1C = 6.71±1.29%) disease, without any complications, treated with diet and/or metformin, were consecutively recruited. Eighteen controls, comparable by sex and age, were enrolled also.<h4>Results</h4>FMD and shear rate FMD were found to be reduced in T2DM subjects with short-term disease (8.5% SD 3.5 and 2.5 SD 1.3, respectively) compared to controls (15.4% SD 4.1 and 3.5 SD 1.4; p<.001 and p<.05). T2DM patients also displayed reduced VMR values than controls (39.4% SD 12.4 vs 51.7%, SD 15.5; p<.05). Sympatho-vagal balance was not different in T2DM patients compared to healthy subjects. FMD and shear rate FMD did not correlate with VMR in T2DM patients or in controls (p>.05).<h4>Conclusions</h4>In well-controlled T2DM patients with short-term disease cerebral hemodynamics and systemic endothelial function are altered while autonomic balance appeared to be preserved.Paola PalazzoPaola MaggioRiccardo AltavillaAlessandra Di FlavianiIlaria GiordaniIlaria MalandruccoFabiana PicconiFrancesco PassarelliPatrizio PasqualettiMatilde ErcolaniFabrizio VernieriSimona FrontoniPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 12, p e83287 (2013) |
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DOAJ |
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Medicine R Science Q |
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Medicine R Science Q Paola Palazzo Paola Maggio Riccardo Altavilla Alessandra Di Flaviani Ilaria Giordani Ilaria Malandrucco Fabiana Picconi Francesco Passarelli Patrizio Pasqualetti Matilde Ercolani Fabrizio Vernieri Simona Frontoni Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease. |
| description |
<h4>Objective</h4>Impaired cerebral vasomotor reactivity (VMR) and flow-mediated dilation (FMD) were found in selected subgroups of type 2 diabetes mellitus (T2DM) patients with long-term disease. Our study aimed to evaluate cerebral hemodynamics, systemic endothelial function and sympatho-vagal balance in a selected population of well-controlled T2DM patients with short-term disease and without cardiac autonomic neuropathy (CAN).<h4>Research design and methods</h4>Twenty-six T2DM patients with short-term (4.40±4.80 years) and well-controlled (HbA1C = 6.71±1.29%) disease, without any complications, treated with diet and/or metformin, were consecutively recruited. Eighteen controls, comparable by sex and age, were enrolled also.<h4>Results</h4>FMD and shear rate FMD were found to be reduced in T2DM subjects with short-term disease (8.5% SD 3.5 and 2.5 SD 1.3, respectively) compared to controls (15.4% SD 4.1 and 3.5 SD 1.4; p<.001 and p<.05). T2DM patients also displayed reduced VMR values than controls (39.4% SD 12.4 vs 51.7%, SD 15.5; p<.05). Sympatho-vagal balance was not different in T2DM patients compared to healthy subjects. FMD and shear rate FMD did not correlate with VMR in T2DM patients or in controls (p>.05).<h4>Conclusions</h4>In well-controlled T2DM patients with short-term disease cerebral hemodynamics and systemic endothelial function are altered while autonomic balance appeared to be preserved. |
| format |
article |
| author |
Paola Palazzo Paola Maggio Riccardo Altavilla Alessandra Di Flaviani Ilaria Giordani Ilaria Malandrucco Fabiana Picconi Francesco Passarelli Patrizio Pasqualetti Matilde Ercolani Fabrizio Vernieri Simona Frontoni |
| author_facet |
Paola Palazzo Paola Maggio Riccardo Altavilla Alessandra Di Flaviani Ilaria Giordani Ilaria Malandrucco Fabiana Picconi Francesco Passarelli Patrizio Pasqualetti Matilde Ercolani Fabrizio Vernieri Simona Frontoni |
| author_sort |
Paola Palazzo |
| title |
Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease. |
| title_short |
Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease. |
| title_full |
Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease. |
| title_fullStr |
Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease. |
| title_full_unstemmed |
Cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease. |
| title_sort |
cerebral hemodynamics and systemic endothelial function are already impaired in well-controlled type 2 diabetic patients, with short-term disease. |
| publisher |
Public Library of Science (PLoS) |
| publishDate |
2013 |
| url |
https://doaj.org/article/85850b54969d4ff59e96108983542975 |
| work_keys_str_mv |
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