SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts

The balance between osteoclast and osteoblast-mediated bone turnover is essential for bone health and homeostasis. Here the authors show that both germline and osteoblast-specificSmurf2-deficient mice have osteoporosis as a result of increased osteoblast RANKL production and excess osteoclastogenesi...

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Autores principales:	Zhan Xu, Matthew B. Greenblatt, Guang Yan, Heng Feng, Jun Sun, Sutada Lotinun, Nicholas Brady, Roland Baron, Laurie H. Glimcher, Weiguo Zou
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/8587ff1da24f4d40938fa5677c4e2328
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spelling	oai:doaj.org-article:8587ff1da24f4d40938fa5677c4e23282021-12-02T14:40:37ZSMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts10.1038/ncomms145702041-1723https://doaj.org/article/8587ff1da24f4d40938fa5677c4e23282017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14570https://doaj.org/toc/2041-1723The balance between osteoclast and osteoblast-mediated bone turnover is essential for bone health and homeostasis. Here the authors show that both germline and osteoblast-specificSmurf2-deficient mice have osteoporosis as a result of increased osteoblast RANKL production and excess osteoclastogenesis.Zhan XuMatthew B. GreenblattGuang YanHeng FengJun SunSutada LotinunNicholas BradyRoland BaronLaurie H. GlimcherWeiguo ZouNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhan Xu Matthew B. Greenblatt Guang Yan Heng Feng Jun Sun Sutada Lotinun Nicholas Brady Roland Baron Laurie H. Glimcher Weiguo Zou SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts
description	The balance between osteoclast and osteoblast-mediated bone turnover is essential for bone health and homeostasis. Here the authors show that both germline and osteoblast-specificSmurf2-deficient mice have osteoporosis as a result of increased osteoblast RANKL production and excess osteoclastogenesis.
format	article
author	Zhan Xu Matthew B. Greenblatt Guang Yan Heng Feng Jun Sun Sutada Lotinun Nicholas Brady Roland Baron Laurie H. Glimcher Weiguo Zou
author_facet	Zhan Xu Matthew B. Greenblatt Guang Yan Heng Feng Jun Sun Sutada Lotinun Nicholas Brady Roland Baron Laurie H. Glimcher Weiguo Zou
author_sort	Zhan Xu
title	SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts
title_short	SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts
title_full	SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts
title_fullStr	SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts
title_full_unstemmed	SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts
title_sort	smurf2 regulates bone homeostasis by disrupting smad3 interaction with vitamin d receptor in osteoblasts
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/8587ff1da24f4d40938fa5677c4e2328
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SMURF2 regulates bone homeostasis by disrupting SMAD3 interaction with vitamin D receptor in osteoblasts

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