Design and Analysis of a Biodegradable Polycaprolactone Flow Diverting Stent for Brain Aneurysms

The flow diverting stent (FDS) has become a promising endovascular device for the treatment of aneurysms. This research presents a novel biodegradable and non-braided Polycaprolactone (PCL) FDS. The PCL FDS was designed and developed using an in-house fabrication unit and coated on two ends with BaS...

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Autores principales:	Kaitlyn Tidwell, Seth Harriet, Vishal Barot, Andrew Bauer, Melville B. Vaughan, Mohammad R. Hossan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	flow diverting stents (FDS) biodegradable aneurysms Polycaprolactone (PCL) flow diverters endovascular treatment Technology T Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/858ad9931561422d9388042822136ab0
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spelling	oai:doaj.org-article:858ad9931561422d9388042822136ab02021-11-25T16:46:39ZDesign and Analysis of a Biodegradable Polycaprolactone Flow Diverting Stent for Brain Aneurysms10.3390/bioengineering81101832306-5354https://doaj.org/article/858ad9931561422d9388042822136ab02021-11-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/183https://doaj.org/toc/2306-5354The flow diverting stent (FDS) has become a promising endovascular device for the treatment of aneurysms. This research presents a novel biodegradable and non-braided Polycaprolactone (PCL) FDS. The PCL FDS was designed and developed using an in-house fabrication unit and coated on two ends with BaSO<sub>4</sub> for angiographic visibility. The mechanical flexibility and quality of FDS surfaces were examined with the UniVert testing machine, scanning electron microscope (SEM), and 3D profilometer. Human umbilical vein endothelial cell (HUVEC) adhesion, proliferation, and cell morphology studies on PCL FDS were performed. The cytotoxicity and NO production by HUVECs with PCL FDS were also conducted. The longitudinal tensile, radial, and bending flexibility were found to be 1.20 ± 0.19 N/mm, 0.56 ± 0.11 N/mm, and 0.34 ± 0.03 N/mm, respectively. The FDS was returned to the original shape and diameter after repeated compression and bending without compromising mechanical integrity. Results also showed that the proliferation and adhesion of HUVECs on the FDS surface increased over time compared to control without FDS. Lactate dehydrogenase (LDH) release and NO production showed that PCL FDS were non-toxic and satisfactory. Cell morphology studies showed that HUVECs were elongated to cover the FD surface and developed an endothelial monolayer. This study is a step forward toward the development and clinical use of biodegradable flow diverting stents for endovascular treatment of the aneurysm.Kaitlyn TidwellSeth HarrietVishal BarotAndrew BauerMelville B. VaughanMohammad R. HossanMDPI AGarticleflow diverting stents (FDS)biodegradableaneurysmsPolycaprolactone (PCL) flow divertersendovascular treatmentTechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 183, p 183 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	flow diverting stents (FDS) biodegradable aneurysms Polycaprolactone (PCL) flow diverters endovascular treatment Technology T Biology (General) QH301-705.5
spellingShingle	flow diverting stents (FDS) biodegradable aneurysms Polycaprolactone (PCL) flow diverters endovascular treatment Technology T Biology (General) QH301-705.5 Kaitlyn Tidwell Seth Harriet Vishal Barot Andrew Bauer Melville B. Vaughan Mohammad R. Hossan Design and Analysis of a Biodegradable Polycaprolactone Flow Diverting Stent for Brain Aneurysms
description	The flow diverting stent (FDS) has become a promising endovascular device for the treatment of aneurysms. This research presents a novel biodegradable and non-braided Polycaprolactone (PCL) FDS. The PCL FDS was designed and developed using an in-house fabrication unit and coated on two ends with BaSO<sub>4</sub> for angiographic visibility. The mechanical flexibility and quality of FDS surfaces were examined with the UniVert testing machine, scanning electron microscope (SEM), and 3D profilometer. Human umbilical vein endothelial cell (HUVEC) adhesion, proliferation, and cell morphology studies on PCL FDS were performed. The cytotoxicity and NO production by HUVECs with PCL FDS were also conducted. The longitudinal tensile, radial, and bending flexibility were found to be 1.20 ± 0.19 N/mm, 0.56 ± 0.11 N/mm, and 0.34 ± 0.03 N/mm, respectively. The FDS was returned to the original shape and diameter after repeated compression and bending without compromising mechanical integrity. Results also showed that the proliferation and adhesion of HUVECs on the FDS surface increased over time compared to control without FDS. Lactate dehydrogenase (LDH) release and NO production showed that PCL FDS were non-toxic and satisfactory. Cell morphology studies showed that HUVECs were elongated to cover the FD surface and developed an endothelial monolayer. This study is a step forward toward the development and clinical use of biodegradable flow diverting stents for endovascular treatment of the aneurysm.
format	article
author	Kaitlyn Tidwell Seth Harriet Vishal Barot Andrew Bauer Melville B. Vaughan Mohammad R. Hossan
author_facet	Kaitlyn Tidwell Seth Harriet Vishal Barot Andrew Bauer Melville B. Vaughan Mohammad R. Hossan
author_sort	Kaitlyn Tidwell
title	Design and Analysis of a Biodegradable Polycaprolactone Flow Diverting Stent for Brain Aneurysms
title_short	Design and Analysis of a Biodegradable Polycaprolactone Flow Diverting Stent for Brain Aneurysms
title_full	Design and Analysis of a Biodegradable Polycaprolactone Flow Diverting Stent for Brain Aneurysms
title_fullStr	Design and Analysis of a Biodegradable Polycaprolactone Flow Diverting Stent for Brain Aneurysms
title_full_unstemmed	Design and Analysis of a Biodegradable Polycaprolactone Flow Diverting Stent for Brain Aneurysms
title_sort	design and analysis of a biodegradable polycaprolactone flow diverting stent for brain aneurysms
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/858ad9931561422d9388042822136ab0
work_keys_str_mv	AT kaitlyntidwell designandanalysisofabiodegradablepolycaprolactoneflowdivertingstentforbrainaneurysms AT sethharriet designandanalysisofabiodegradablepolycaprolactoneflowdivertingstentforbrainaneurysms AT vishalbarot designandanalysisofabiodegradablepolycaprolactoneflowdivertingstentforbrainaneurysms AT andrewbauer designandanalysisofabiodegradablepolycaprolactoneflowdivertingstentforbrainaneurysms AT melvillebvaughan designandanalysisofabiodegradablepolycaprolactoneflowdivertingstentforbrainaneurysms AT mohammadrhossan designandanalysisofabiodegradablepolycaprolactoneflowdivertingstentforbrainaneurysms
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Design and Analysis of a Biodegradable Polycaprolactone Flow Diverting Stent for Brain Aneurysms

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