The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats

Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda Abdo Yahya Qaid1 1Department of Physics and Astronomy, College of Sciences, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Scien...

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Autores principales: Abdelhalim MAK, Moussa SA, Qaid HAY
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Publicado: Dove Medical Press 2018
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spelling oai:doaj.org-article:858d3e7789944161968cc355245ccf732021-12-02T03:19:10ZThe protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats1178-2013https://doaj.org/article/858d3e7789944161968cc355245ccf732018-05-01T00:00:00Zhttps://www.dovepress.com/the-protective-role-of-quercetin-and-arginine-on-gold-nanoparticles-in-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda Abdo Yahya Qaid1 1Department of Physics and Astronomy, College of Sciences, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; 3Biophysics Group, Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, Giza, Egypt Background: The aim of the study was to confirm the hepatotoxicity induced by small-sized gold nanoparticles (GNPs) and evaluate the role of quercetin (Qur) and arginine (Arg) against hepatotoxicity caused by GNPs.Methods: Twenty-five healthy male Wistar-Kyoto rats were used. GNPs were administered intraperitoneally to these rats at the dose of 50 µL for seven consecutive days. The role of Qur and Arg antioxidants against toxicity induced by GNPs was detected through the measurement of serum liver function and oxidative stress biomarkers in the liver tissues.Results: Coadministration of Qur and Arg along with GNPs significantly induced dramatic alterations in the biochemical parameters. Levels of malondialdehyde, gamma-glutamyl transferase, alanine aminotransferase, alkaline phosphatase, and total protein increased significantly in the GNPs injected group than in the control group, while reduced glutathione was greatly reduced in the GNPs group than in the control group. It also significantly decreased liver enzymes and the oxidative stress, therefore improving the liver damage and hepatotoxicity induced by GNPs.Conclusion: This study demonstrated that Qur and Arg antioxidants effectively improved the hepatic oxidative damage induced by GNPs. It also substantiates the application of Qur and Arg as protecting stand-in against GNPs’ hepatotoxicity. Keywords: antioxidants, oxidative stress, gold nanoparticles, hepatotoxicity, quercetin, arginine, ratsAbdelhalim MAKMoussa SAQaid HAYDove Medical PressarticleAntioxidantsoxidative stressgold nanoparticleshepatotoxicityQuercetinArginineratsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2821-2825 (2018)
institution DOAJ
collection DOAJ
language EN
topic Antioxidants
oxidative stress
gold nanoparticles
hepatotoxicity
Quercetin
Arginine
rats
Medicine (General)
R5-920
spellingShingle Antioxidants
oxidative stress
gold nanoparticles
hepatotoxicity
Quercetin
Arginine
rats
Medicine (General)
R5-920
Abdelhalim MAK
Moussa SA
Qaid HAY
The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats
description Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda Abdo Yahya Qaid1 1Department of Physics and Astronomy, College of Sciences, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; 3Biophysics Group, Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, Giza, Egypt Background: The aim of the study was to confirm the hepatotoxicity induced by small-sized gold nanoparticles (GNPs) and evaluate the role of quercetin (Qur) and arginine (Arg) against hepatotoxicity caused by GNPs.Methods: Twenty-five healthy male Wistar-Kyoto rats were used. GNPs were administered intraperitoneally to these rats at the dose of 50 µL for seven consecutive days. The role of Qur and Arg antioxidants against toxicity induced by GNPs was detected through the measurement of serum liver function and oxidative stress biomarkers in the liver tissues.Results: Coadministration of Qur and Arg along with GNPs significantly induced dramatic alterations in the biochemical parameters. Levels of malondialdehyde, gamma-glutamyl transferase, alanine aminotransferase, alkaline phosphatase, and total protein increased significantly in the GNPs injected group than in the control group, while reduced glutathione was greatly reduced in the GNPs group than in the control group. It also significantly decreased liver enzymes and the oxidative stress, therefore improving the liver damage and hepatotoxicity induced by GNPs.Conclusion: This study demonstrated that Qur and Arg antioxidants effectively improved the hepatic oxidative damage induced by GNPs. It also substantiates the application of Qur and Arg as protecting stand-in against GNPs’ hepatotoxicity. Keywords: antioxidants, oxidative stress, gold nanoparticles, hepatotoxicity, quercetin, arginine, rats
format article
author Abdelhalim MAK
Moussa SA
Qaid HAY
author_facet Abdelhalim MAK
Moussa SA
Qaid HAY
author_sort Abdelhalim MAK
title The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats
title_short The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats
title_full The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats
title_fullStr The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats
title_full_unstemmed The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats
title_sort protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/858d3e7789944161968cc355245ccf73
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