The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats
Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda Abdo Yahya Qaid1 1Department of Physics and Astronomy, College of Sciences, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Scien...
Guardado en:
Autores principales: | , , |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Dove Medical Press
2018
|
Materias: | |
Acceso en línea: | https://doaj.org/article/858d3e7789944161968cc355245ccf73 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:doaj.org-article:858d3e7789944161968cc355245ccf73 |
---|---|
record_format |
dspace |
spelling |
oai:doaj.org-article:858d3e7789944161968cc355245ccf732021-12-02T03:19:10ZThe protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats1178-2013https://doaj.org/article/858d3e7789944161968cc355245ccf732018-05-01T00:00:00Zhttps://www.dovepress.com/the-protective-role-of-quercetin-and-arginine-on-gold-nanoparticles-in-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda Abdo Yahya Qaid1 1Department of Physics and Astronomy, College of Sciences, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; 3Biophysics Group, Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, Giza, Egypt Background: The aim of the study was to confirm the hepatotoxicity induced by small-sized gold nanoparticles (GNPs) and evaluate the role of quercetin (Qur) and arginine (Arg) against hepatotoxicity caused by GNPs.Methods: Twenty-five healthy male Wistar-Kyoto rats were used. GNPs were administered intraperitoneally to these rats at the dose of 50 µL for seven consecutive days. The role of Qur and Arg antioxidants against toxicity induced by GNPs was detected through the measurement of serum liver function and oxidative stress biomarkers in the liver tissues.Results: Coadministration of Qur and Arg along with GNPs significantly induced dramatic alterations in the biochemical parameters. Levels of malondialdehyde, gamma-glutamyl transferase, alanine aminotransferase, alkaline phosphatase, and total protein increased significantly in the GNPs injected group than in the control group, while reduced glutathione was greatly reduced in the GNPs group than in the control group. It also significantly decreased liver enzymes and the oxidative stress, therefore improving the liver damage and hepatotoxicity induced by GNPs.Conclusion: This study demonstrated that Qur and Arg antioxidants effectively improved the hepatic oxidative damage induced by GNPs. It also substantiates the application of Qur and Arg as protecting stand-in against GNPs’ hepatotoxicity. Keywords: antioxidants, oxidative stress, gold nanoparticles, hepatotoxicity, quercetin, arginine, ratsAbdelhalim MAKMoussa SAQaid HAYDove Medical PressarticleAntioxidantsoxidative stressgold nanoparticleshepatotoxicityQuercetinArginineratsMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 13, Pp 2821-2825 (2018) |
institution |
DOAJ |
collection |
DOAJ |
language |
EN |
topic |
Antioxidants oxidative stress gold nanoparticles hepatotoxicity Quercetin Arginine rats Medicine (General) R5-920 |
spellingShingle |
Antioxidants oxidative stress gold nanoparticles hepatotoxicity Quercetin Arginine rats Medicine (General) R5-920 Abdelhalim MAK Moussa SA Qaid HAY The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats |
description |
Mohamed Anwar K Abdelhalim,1 Sherif A Abdelmottaleb Moussa,2,3 Huda Abdo Yahya Qaid1 1Department of Physics and Astronomy, College of Sciences, King Saud University, Riyadh, Saudi Arabia; 2Committee of Radiation and Environmental Pollution Protection (CREPP), Department of Physics, College of Science, Al-Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia; 3Biophysics Group, Biochemistry Department, Genetic Engineering and Biotechnology Division, National Research Centre, Giza, Egypt Background: The aim of the study was to confirm the hepatotoxicity induced by small-sized gold nanoparticles (GNPs) and evaluate the role of quercetin (Qur) and arginine (Arg) against hepatotoxicity caused by GNPs.Methods: Twenty-five healthy male Wistar-Kyoto rats were used. GNPs were administered intraperitoneally to these rats at the dose of 50 µL for seven consecutive days. The role of Qur and Arg antioxidants against toxicity induced by GNPs was detected through the measurement of serum liver function and oxidative stress biomarkers in the liver tissues.Results: Coadministration of Qur and Arg along with GNPs significantly induced dramatic alterations in the biochemical parameters. Levels of malondialdehyde, gamma-glutamyl transferase, alanine aminotransferase, alkaline phosphatase, and total protein increased significantly in the GNPs injected group than in the control group, while reduced glutathione was greatly reduced in the GNPs group than in the control group. It also significantly decreased liver enzymes and the oxidative stress, therefore improving the liver damage and hepatotoxicity induced by GNPs.Conclusion: This study demonstrated that Qur and Arg antioxidants effectively improved the hepatic oxidative damage induced by GNPs. It also substantiates the application of Qur and Arg as protecting stand-in against GNPs’ hepatotoxicity. Keywords: antioxidants, oxidative stress, gold nanoparticles, hepatotoxicity, quercetin, arginine, rats |
format |
article |
author |
Abdelhalim MAK Moussa SA Qaid HAY |
author_facet |
Abdelhalim MAK Moussa SA Qaid HAY |
author_sort |
Abdelhalim MAK |
title |
The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats |
title_short |
The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats |
title_full |
The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats |
title_fullStr |
The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats |
title_full_unstemmed |
The protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats |
title_sort |
protective role of quercetin and arginine on gold nanoparticles induced hepatotoxicity in rats |
publisher |
Dove Medical Press |
publishDate |
2018 |
url |
https://doaj.org/article/858d3e7789944161968cc355245ccf73 |
work_keys_str_mv |
AT abdelhalimmak theprotectiveroleofquercetinandarginineongoldnanoparticlesinducedhepatotoxicityinrats AT moussasa theprotectiveroleofquercetinandarginineongoldnanoparticlesinducedhepatotoxicityinrats AT qaidhay theprotectiveroleofquercetinandarginineongoldnanoparticlesinducedhepatotoxicityinrats AT abdelhalimmak protectiveroleofquercetinandarginineongoldnanoparticlesinducedhepatotoxicityinrats AT moussasa protectiveroleofquercetinandarginineongoldnanoparticlesinducedhepatotoxicityinrats AT qaidhay protectiveroleofquercetinandarginineongoldnanoparticlesinducedhepatotoxicityinrats |
_version_ |
1718401805447069696 |