Cardiovascular complications and its impact on outcomes in COVID-19: An original research

Introduction: The viral infection COVID-19 is highly infectious and has claimed many lives till date and is still continuing to consume lives. In the COVID-19, along with pulmonary symptoms, cardiovascular (CV) events were also recorded that have known to significantly contribute to the mortality. I...

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Autores principales:	Prashant Kumar, Kaousthubh Tiwari, Siva Kumar Pendyala, Ratnesh Kumar Jaiswal, Neelathil Lisa Chacko, Ekta Srivastava, Rahul V C Tiwari
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	cardiovascular events covid-19 scoring system Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
Acceso en línea:	https://doaj.org/article/858dc58d59864eddbe68294b86802d78
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spelling	oai:doaj.org-article:858dc58d59864eddbe68294b86802d782021-11-19T12:15:52ZCardiovascular complications and its impact on outcomes in COVID-19: An original research0975-740610.4103/jpbs.jpbs_143_21https://doaj.org/article/858dc58d59864eddbe68294b86802d782021-01-01T00:00:00Zhttp://www.jpbsonline.org/article.asp?issn=0975-7406;year=2021;volume=13;issue=6;spage=1333;epage=1337;aulast=Kumarhttps://doaj.org/toc/0975-7406Introduction: The viral infection COVID-19 is highly infectious and has claimed many lives till date and is still continuing to consume lives. In the COVID-19, along with pulmonary symptoms, cardiovascular (CV) events were also recorded that have known to significantly contribute to the mortality. In our study, we designed and validated a new risk score that can predict CV events, and also evaluated the effect of these complications on the prognosis in COVID-19 patients. Materials and Methods: A retrospective, multicenter, observational study was done among 1000 laboratory-confirmed COVID-19 patients between June 2020 and December 2020. All the data of the clinical and laboratory parameters were collected. Patients were randomly divided into two groups for testing and validating the hypothesis. The identification of the independent risk factors was done by the logistic regression analysis method. Results: Of all the types of the clinical and laboratory parameters, ten “independent risk factors” were identified associated with CV events in Group A: male gender, older age, chronic heart disease, cough, lymphocyte count <1.1 × 109/L at admission, blood urea nitrogen >7 mmol/L at admission, estimated glomerular filtration rate <90 ml/min/1.73 m2 at admission, activated partial thromboplastin time >37 S, D-dimer, and procalcitonin >0.5 mg/L. In our study, we found that CV events were significantly related with inferior prognosis (P < 0.001). Conclusions: A new risk scoring system was designed in our study, which may be used as a predictive tool for CV complications among the patients with COVID-19 infection.Prashant KumarKaousthubh TiwariSiva Kumar PendyalaRatnesh Kumar JaiswalNeelathil Lisa ChackoEkta SrivastavaRahul V C TiwariWolters Kluwer Medknow Publicationsarticlecardiovascular eventscovid-19scoring systemPharmacy and materia medicaRS1-441Analytical chemistryQD71-142ENJournal of Pharmacy and Bioallied Sciences, Vol 13, Iss 6, Pp 1333-1337 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiovascular events covid-19 scoring system Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142
spellingShingle	cardiovascular events covid-19 scoring system Pharmacy and materia medica RS1-441 Analytical chemistry QD71-142 Prashant Kumar Kaousthubh Tiwari Siva Kumar Pendyala Ratnesh Kumar Jaiswal Neelathil Lisa Chacko Ekta Srivastava Rahul V C Tiwari Cardiovascular complications and its impact on outcomes in COVID-19: An original research
description	Introduction: The viral infection COVID-19 is highly infectious and has claimed many lives till date and is still continuing to consume lives. In the COVID-19, along with pulmonary symptoms, cardiovascular (CV) events were also recorded that have known to significantly contribute to the mortality. In our study, we designed and validated a new risk score that can predict CV events, and also evaluated the effect of these complications on the prognosis in COVID-19 patients. Materials and Methods: A retrospective, multicenter, observational study was done among 1000 laboratory-confirmed COVID-19 patients between June 2020 and December 2020. All the data of the clinical and laboratory parameters were collected. Patients were randomly divided into two groups for testing and validating the hypothesis. The identification of the independent risk factors was done by the logistic regression analysis method. Results: Of all the types of the clinical and laboratory parameters, ten “independent risk factors” were identified associated with CV events in Group A: male gender, older age, chronic heart disease, cough, lymphocyte count <1.1 × 109/L at admission, blood urea nitrogen >7 mmol/L at admission, estimated glomerular filtration rate <90 ml/min/1.73 m2 at admission, activated partial thromboplastin time >37 S, D-dimer, and procalcitonin >0.5 mg/L. In our study, we found that CV events were significantly related with inferior prognosis (P < 0.001). Conclusions: A new risk scoring system was designed in our study, which may be used as a predictive tool for CV complications among the patients with COVID-19 infection.
format	article
author	Prashant Kumar Kaousthubh Tiwari Siva Kumar Pendyala Ratnesh Kumar Jaiswal Neelathil Lisa Chacko Ekta Srivastava Rahul V C Tiwari
author_facet	Prashant Kumar Kaousthubh Tiwari Siva Kumar Pendyala Ratnesh Kumar Jaiswal Neelathil Lisa Chacko Ekta Srivastava Rahul V C Tiwari
author_sort	Prashant Kumar
title	Cardiovascular complications and its impact on outcomes in COVID-19: An original research
title_short	Cardiovascular complications and its impact on outcomes in COVID-19: An original research
title_full	Cardiovascular complications and its impact on outcomes in COVID-19: An original research
title_fullStr	Cardiovascular complications and its impact on outcomes in COVID-19: An original research
title_full_unstemmed	Cardiovascular complications and its impact on outcomes in COVID-19: An original research
title_sort	cardiovascular complications and its impact on outcomes in covid-19: an original research
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/858dc58d59864eddbe68294b86802d78
work_keys_str_mv	AT prashantkumar cardiovascularcomplicationsanditsimpactonoutcomesincovid19anoriginalresearch AT kaousthubhtiwari cardiovascularcomplicationsanditsimpactonoutcomesincovid19anoriginalresearch AT sivakumarpendyala cardiovascularcomplicationsanditsimpactonoutcomesincovid19anoriginalresearch AT ratneshkumarjaiswal cardiovascularcomplicationsanditsimpactonoutcomesincovid19anoriginalresearch AT neelathillisachacko cardiovascularcomplicationsanditsimpactonoutcomesincovid19anoriginalresearch AT ektasrivastava cardiovascularcomplicationsanditsimpactonoutcomesincovid19anoriginalresearch AT rahulvctiwari cardiovascularcomplicationsanditsimpactonoutcomesincovid19anoriginalresearch
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Cardiovascular complications and its impact on outcomes in COVID-19: An original research

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