Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.

<h4>Background</h4>Adult mesenchymal stem cells (MSCs) can be maintained over extended periods of time before activation and differentiation. Little is known about the programs that sustain the survival of these cells.<h4>Principal findings</h4>Undifferentiated adult human MS...

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Autores principales:	Lisa Oliver, Erika Hue, Julien Rossignol, Gwenola Bougras, Philippe Hulin, Philippe Naveilhan, Dominique Heymann, Laurent Lescaudron, François M Vallette
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/859228ef94cc4e2c8f3825ee4f660ba6
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spelling	oai:doaj.org-article:859228ef94cc4e2c8f3825ee4f660ba62021-11-18T06:54:05ZDistinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.1932-620310.1371/journal.pone.0019820https://doaj.org/article/859228ef94cc4e2c8f3825ee4f660ba62011-05-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21589877/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Adult mesenchymal stem cells (MSCs) can be maintained over extended periods of time before activation and differentiation. Little is known about the programs that sustain the survival of these cells.<h4>Principal findings</h4>Undifferentiated adult human MSCs (hMSCs) did not undergo apoptosis in response to different cell death inducers. Conversely, the same inducers can readily induce apoptosis when hMSCs are engaged in the early stages of differentiation. The survival of undifferentiated cells is linked to the expression of Bcl-Xl and Bcl-2 in completely opposite ways. Bcl-Xl is expressed at similar levels in undifferentiated and differentiated hMSCs while Bcl-2 is expressed only in differentiated cells. In undifferentiated hMSCs, the down-regulation of Bcl-Xl is associated with an increased sensitivity to apoptosis while the ectopic expression of Bcl-2 induced apoptosis. This apoptosis is linked to the presence of cytoplasmic Nur 77 in undifferentiated hMSCs.<h4>Significance</h4>In hMSCs, the expression of Bcl-2 depends on cellular differentiation and can be either pro- or anti-apoptotic. Bcl-Xl, on the other hand, exhibits an anti-apoptotic activity under all conditions.Lisa OliverErika HueJulien RossignolGwenola BougrasPhilippe HulinPhilippe NaveilhanDominique HeymannLaurent LescaudronFrançois M VallettePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 5, p e19820 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lisa Oliver Erika Hue Julien Rossignol Gwenola Bougras Philippe Hulin Philippe Naveilhan Dominique Heymann Laurent Lescaudron François M Vallette Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.
description	<h4>Background</h4>Adult mesenchymal stem cells (MSCs) can be maintained over extended periods of time before activation and differentiation. Little is known about the programs that sustain the survival of these cells.<h4>Principal findings</h4>Undifferentiated adult human MSCs (hMSCs) did not undergo apoptosis in response to different cell death inducers. Conversely, the same inducers can readily induce apoptosis when hMSCs are engaged in the early stages of differentiation. The survival of undifferentiated cells is linked to the expression of Bcl-Xl and Bcl-2 in completely opposite ways. Bcl-Xl is expressed at similar levels in undifferentiated and differentiated hMSCs while Bcl-2 is expressed only in differentiated cells. In undifferentiated hMSCs, the down-regulation of Bcl-Xl is associated with an increased sensitivity to apoptosis while the ectopic expression of Bcl-2 induced apoptosis. This apoptosis is linked to the presence of cytoplasmic Nur 77 in undifferentiated hMSCs.<h4>Significance</h4>In hMSCs, the expression of Bcl-2 depends on cellular differentiation and can be either pro- or anti-apoptotic. Bcl-Xl, on the other hand, exhibits an anti-apoptotic activity under all conditions.
format	article
author	Lisa Oliver Erika Hue Julien Rossignol Gwenola Bougras Philippe Hulin Philippe Naveilhan Dominique Heymann Laurent Lescaudron François M Vallette
author_facet	Lisa Oliver Erika Hue Julien Rossignol Gwenola Bougras Philippe Hulin Philippe Naveilhan Dominique Heymann Laurent Lescaudron François M Vallette
author_sort	Lisa Oliver
title	Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.
title_short	Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.
title_full	Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.
title_fullStr	Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.
title_full_unstemmed	Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.
title_sort	distinct roles of bcl-2 and bcl-xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/859228ef94cc4e2c8f3825ee4f660ba6
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Distinct roles of Bcl-2 and Bcl-Xl in the apoptosis of human bone marrow mesenchymal stem cells during differentiation.

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