Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma

Abstract Background Tissue inhibitors of metalloproteinase (TIMP) family proteins are peptidases involved in extracellular matrix (ECM) degradation. Various diseases are related to TIMPs, and the primary reason is that TIMPs can indirectly regulate remodelling of the ECM and cell signalling by regul...

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Autores principales:	Jinkun Han, Yajun Jing, Fubing Han, Peng Sun
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Bioinformatics analysis Tissue inhibitors of metalloproteinases family Glioblastoma Biomarker Prognosis Immune infiltration Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/8594ef83a918433bb13445844b10a59e
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spelling	oai:doaj.org-article:8594ef83a918433bb13445844b10a59e2021-11-21T12:09:34ZComprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma10.1186/s12883-021-02477-11471-2377https://doaj.org/article/8594ef83a918433bb13445844b10a59e2021-11-01T00:00:00Zhttps://doi.org/10.1186/s12883-021-02477-1https://doaj.org/toc/1471-2377Abstract Background Tissue inhibitors of metalloproteinase (TIMP) family proteins are peptidases involved in extracellular matrix (ECM) degradation. Various diseases are related to TIMPs, and the primary reason is that TIMPs can indirectly regulate remodelling of the ECM and cell signalling by regulating matrix metalloproteinase (MMP) activity. However, the link between TIMPs and glioblastoma (GBM) is unclear. Objective This study aimed to explore the role of TIMP expression and immune infiltration in GBM. Methods Oncomine, GEPIA, OSgbm, LinkedOmics, STRING, GeneMANIA, Enrichr, and TIMER were used to conduct differential expression, prognosis, and immune infiltration analyses of TIMPs in GBM. Results All members of the TIMP family had significantly higher expression levels in GBM. High TIMP3 expression correlated with better overall survival (OS) and disease-specific survival (DSS) in GBM patients. TIMP4 was associated with a long OS in GBM patients. We found a positive relationship between TIMP3 and TIMP4, identifying gene sets with similar or opposite expression directions to those in GBM patients. TIMPs and associated genes are mainly associated with extracellular matrix organization and involve proteoglycan pathways in cancer. The expression levels of TIMPs in GBM correlate with the infiltration of various immune cells, including CD4+ T cells, macrophages, neutrophils, B cells, CD8+ T cells, and dendritic cells. Conclusions Our study inspires new ideas for the role of TIMPs in GBM and provides new directions for multiple treatment modalities, including immunotherapy, in GBM.Jinkun HanYajun JingFubing HanPeng SunBMCarticleBioinformatics analysisTissue inhibitors of metalloproteinases familyGlioblastomaBiomarkerPrognosisImmune infiltrationNeurology. Diseases of the nervous systemRC346-429ENBMC Neurology, Vol 21, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Bioinformatics analysis Tissue inhibitors of metalloproteinases family Glioblastoma Biomarker Prognosis Immune infiltration Neurology. Diseases of the nervous system RC346-429
spellingShingle	Bioinformatics analysis Tissue inhibitors of metalloproteinases family Glioblastoma Biomarker Prognosis Immune infiltration Neurology. Diseases of the nervous system RC346-429 Jinkun Han Yajun Jing Fubing Han Peng Sun Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma
description	Abstract Background Tissue inhibitors of metalloproteinase (TIMP) family proteins are peptidases involved in extracellular matrix (ECM) degradation. Various diseases are related to TIMPs, and the primary reason is that TIMPs can indirectly regulate remodelling of the ECM and cell signalling by regulating matrix metalloproteinase (MMP) activity. However, the link between TIMPs and glioblastoma (GBM) is unclear. Objective This study aimed to explore the role of TIMP expression and immune infiltration in GBM. Methods Oncomine, GEPIA, OSgbm, LinkedOmics, STRING, GeneMANIA, Enrichr, and TIMER were used to conduct differential expression, prognosis, and immune infiltration analyses of TIMPs in GBM. Results All members of the TIMP family had significantly higher expression levels in GBM. High TIMP3 expression correlated with better overall survival (OS) and disease-specific survival (DSS) in GBM patients. TIMP4 was associated with a long OS in GBM patients. We found a positive relationship between TIMP3 and TIMP4, identifying gene sets with similar or opposite expression directions to those in GBM patients. TIMPs and associated genes are mainly associated with extracellular matrix organization and involve proteoglycan pathways in cancer. The expression levels of TIMPs in GBM correlate with the infiltration of various immune cells, including CD4+ T cells, macrophages, neutrophils, B cells, CD8+ T cells, and dendritic cells. Conclusions Our study inspires new ideas for the role of TIMPs in GBM and provides new directions for multiple treatment modalities, including immunotherapy, in GBM.
format	article
author	Jinkun Han Yajun Jing Fubing Han Peng Sun
author_facet	Jinkun Han Yajun Jing Fubing Han Peng Sun
author_sort	Jinkun Han
title	Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma
title_short	Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma
title_full	Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma
title_fullStr	Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma
title_full_unstemmed	Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma
title_sort	comprehensive analysis of expression, prognosis and immune infiltration for timps in glioblastoma
publisher	BMC
publishDate	2021
url	https://doaj.org/article/8594ef83a918433bb13445844b10a59e
work_keys_str_mv	AT jinkunhan comprehensiveanalysisofexpressionprognosisandimmuneinfiltrationfortimpsinglioblastoma AT yajunjing comprehensiveanalysisofexpressionprognosisandimmuneinfiltrationfortimpsinglioblastoma AT fubinghan comprehensiveanalysisofexpressionprognosisandimmuneinfiltrationfortimpsinglioblastoma AT pengsun comprehensiveanalysisofexpressionprognosisandimmuneinfiltrationfortimpsinglioblastoma
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Comprehensive analysis of expression, prognosis and immune infiltration for TIMPs in glioblastoma

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