Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling

Zika virus can be sexually transmitted. Here, Pletnev et al. show in an immunocompromised mouse model that the epithelial cells of the epididymis, rather than cells of the testis, vas deferens, prostate, or seminal vesicles, are the most likely source of male-to-female sexually transmitted ZIKV geno...

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Autores principales: Alexander G. Pletnev, Olga A. Maximova, Guangping Liu, Heather Kenney, Bianca M. Nagata, Tatiana Zagorodnyaya, Ian Moore, Konstantin Chumakov, Konstantin A. Tsetsarkin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/859a17f5c2b347d9ba22180804596e2c
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spelling oai:doaj.org-article:859a17f5c2b347d9ba22180804596e2c2021-12-02T13:41:32ZEpididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling10.1038/s41467-021-22729-52041-1723https://doaj.org/article/859a17f5c2b347d9ba22180804596e2c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22729-5https://doaj.org/toc/2041-1723Zika virus can be sexually transmitted. Here, Pletnev et al. show in an immunocompromised mouse model that the epithelial cells of the epididymis, rather than cells of the testis, vas deferens, prostate, or seminal vesicles, are the most likely source of male-to-female sexually transmitted ZIKV genomes.Alexander G. PletnevOlga A. MaximovaGuangping LiuHeather KenneyBianca M. NagataTatiana ZagorodnyayaIan MooreKonstantin ChumakovKonstantin A. TsetsarkinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Alexander G. Pletnev
Olga A. Maximova
Guangping Liu
Heather Kenney
Bianca M. Nagata
Tatiana Zagorodnyaya
Ian Moore
Konstantin Chumakov
Konstantin A. Tsetsarkin
Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
description Zika virus can be sexually transmitted. Here, Pletnev et al. show in an immunocompromised mouse model that the epithelial cells of the epididymis, rather than cells of the testis, vas deferens, prostate, or seminal vesicles, are the most likely source of male-to-female sexually transmitted ZIKV genomes.
format article
author Alexander G. Pletnev
Olga A. Maximova
Guangping Liu
Heather Kenney
Bianca M. Nagata
Tatiana Zagorodnyaya
Ian Moore
Konstantin Chumakov
Konstantin A. Tsetsarkin
author_facet Alexander G. Pletnev
Olga A. Maximova
Guangping Liu
Heather Kenney
Bianca M. Nagata
Tatiana Zagorodnyaya
Ian Moore
Konstantin Chumakov
Konstantin A. Tsetsarkin
author_sort Alexander G. Pletnev
title Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
title_short Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
title_full Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
title_fullStr Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
title_full_unstemmed Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
title_sort epididymal epithelium propels early sexual transmission of zika virus in the absence of interferon signaling
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/859a17f5c2b347d9ba22180804596e2c
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