Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling

Zika virus can be sexually transmitted. Here, Pletnev et al. show in an immunocompromised mouse model that the epithelial cells of the epididymis, rather than cells of the testis, vas deferens, prostate, or seminal vesicles, are the most likely source of male-to-female sexually transmitted ZIKV geno...

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Auteurs principaux:	Alexander G. Pletnev, Olga A. Maximova, Guangping Liu, Heather Kenney, Bianca M. Nagata, Tatiana Zagorodnyaya, Ian Moore, Konstantin Chumakov, Konstantin A. Tsetsarkin
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/859a17f5c2b347d9ba22180804596e2c
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spelling	oai:doaj.org-article:859a17f5c2b347d9ba22180804596e2c2021-12-02T13:41:32ZEpididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling10.1038/s41467-021-22729-52041-1723https://doaj.org/article/859a17f5c2b347d9ba22180804596e2c2021-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22729-5https://doaj.org/toc/2041-1723Zika virus can be sexually transmitted. Here, Pletnev et al. show in an immunocompromised mouse model that the epithelial cells of the epididymis, rather than cells of the testis, vas deferens, prostate, or seminal vesicles, are the most likely source of male-to-female sexually transmitted ZIKV genomes.Alexander G. PletnevOlga A. MaximovaGuangping LiuHeather KenneyBianca M. NagataTatiana ZagorodnyayaIan MooreKonstantin ChumakovKonstantin A. TsetsarkinNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alexander G. Pletnev Olga A. Maximova Guangping Liu Heather Kenney Bianca M. Nagata Tatiana Zagorodnyaya Ian Moore Konstantin Chumakov Konstantin A. Tsetsarkin Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
description	Zika virus can be sexually transmitted. Here, Pletnev et al. show in an immunocompromised mouse model that the epithelial cells of the epididymis, rather than cells of the testis, vas deferens, prostate, or seminal vesicles, are the most likely source of male-to-female sexually transmitted ZIKV genomes.
format	article
author	Alexander G. Pletnev Olga A. Maximova Guangping Liu Heather Kenney Bianca M. Nagata Tatiana Zagorodnyaya Ian Moore Konstantin Chumakov Konstantin A. Tsetsarkin
author_facet	Alexander G. Pletnev Olga A. Maximova Guangping Liu Heather Kenney Bianca M. Nagata Tatiana Zagorodnyaya Ian Moore Konstantin Chumakov Konstantin A. Tsetsarkin
author_sort	Alexander G. Pletnev
title	Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
title_short	Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
title_full	Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
title_fullStr	Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
title_full_unstemmed	Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling
title_sort	epididymal epithelium propels early sexual transmission of zika virus in the absence of interferon signaling
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/859a17f5c2b347d9ba22180804596e2c
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Epididymal epithelium propels early sexual transmission of Zika virus in the absence of interferon signaling

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