Genome Diversity and the Origin of the Arabian Horse

Abstract The Arabian horse, one of the world’s oldest breeds of any domesticated animal, is characterized by natural beauty, graceful movement, athletic endurance, and, as a result of its development in the arid Middle East, the ability to thrive in a hot, dry environment. Here we studied 378 Arabia...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Elissa J. Cosgrove, Raheleh Sadeghi, Florencia Schlamp, Heather M. Holl, Mohammad Moradi-Shahrbabak, Seyed Reza Miraei-Ashtiani, Salma Abdalla, Ben Shykind, Mats Troedsson, Monika Stefaniuk-Szmukier, Anil Prabhu, Stefania Bucca, Monika Bugno-Poniewierska, Barbara Wallner, Joel Malek, Donald C. Miller, Andrew G. Clark, Douglas F. Antczak, Samantha A. Brooks
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/859c1142aad7479ca7f2b0952b30f575
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:859c1142aad7479ca7f2b0952b30f575
record_format	dspace
spelling	oai:doaj.org-article:859c1142aad7479ca7f2b0952b30f5752021-12-02T17:40:44ZGenome Diversity and the Origin of the Arabian Horse10.1038/s41598-020-66232-12045-2322https://doaj.org/article/859c1142aad7479ca7f2b0952b30f5752020-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-66232-1https://doaj.org/toc/2045-2322Abstract The Arabian horse, one of the world’s oldest breeds of any domesticated animal, is characterized by natural beauty, graceful movement, athletic endurance, and, as a result of its development in the arid Middle East, the ability to thrive in a hot, dry environment. Here we studied 378 Arabian horses from 12 countries using equine single nucleotide polymorphism (SNP) arrays and whole-genome re-sequencing to examine hypotheses about genomic diversity, population structure, and the relationship of the Arabian to other horse breeds. We identified a high degree of genetic variation and complex ancestry in Arabian horses from the Middle East region. Also, contrary to popular belief, we could detect no significant genomic contribution of the Arabian breed to the Thoroughbred racehorse, including Y chromosome ancestry. However, we found strong evidence for recent interbreeding of Thoroughbreds with Arabians used for flat-racing competitions. Genetic signatures suggestive of selective sweeps across the Arabian breed contain candidate genes for combating oxidative damage during exercise, and within the “Straight Egyptian” subgroup, for facial morphology. Overall, our data support an origin of the Arabian horse in the Middle East, no evidence for reduced global genetic diversity across the breed, and unique genetic adaptations for both physiology and conformation.Elissa J. CosgroveRaheleh SadeghiFlorencia SchlampHeather M. HollMohammad Moradi-ShahrbabakSeyed Reza Miraei-AshtianiSalma AbdallaBen ShykindMats TroedssonMonika Stefaniuk-SzmukierAnil PrabhuStefania BuccaMonika Bugno-PoniewierskaBarbara WallnerJoel MalekDonald C. MillerAndrew G. ClarkDouglas F. AntczakSamantha A. BrooksNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Elissa J. Cosgrove Raheleh Sadeghi Florencia Schlamp Heather M. Holl Mohammad Moradi-Shahrbabak Seyed Reza Miraei-Ashtiani Salma Abdalla Ben Shykind Mats Troedsson Monika Stefaniuk-Szmukier Anil Prabhu Stefania Bucca Monika Bugno-Poniewierska Barbara Wallner Joel Malek Donald C. Miller Andrew G. Clark Douglas F. Antczak Samantha A. Brooks Genome Diversity and the Origin of the Arabian Horse
description	Abstract The Arabian horse, one of the world’s oldest breeds of any domesticated animal, is characterized by natural beauty, graceful movement, athletic endurance, and, as a result of its development in the arid Middle East, the ability to thrive in a hot, dry environment. Here we studied 378 Arabian horses from 12 countries using equine single nucleotide polymorphism (SNP) arrays and whole-genome re-sequencing to examine hypotheses about genomic diversity, population structure, and the relationship of the Arabian to other horse breeds. We identified a high degree of genetic variation and complex ancestry in Arabian horses from the Middle East region. Also, contrary to popular belief, we could detect no significant genomic contribution of the Arabian breed to the Thoroughbred racehorse, including Y chromosome ancestry. However, we found strong evidence for recent interbreeding of Thoroughbreds with Arabians used for flat-racing competitions. Genetic signatures suggestive of selective sweeps across the Arabian breed contain candidate genes for combating oxidative damage during exercise, and within the “Straight Egyptian” subgroup, for facial morphology. Overall, our data support an origin of the Arabian horse in the Middle East, no evidence for reduced global genetic diversity across the breed, and unique genetic adaptations for both physiology and conformation.
format	article
author	Elissa J. Cosgrove Raheleh Sadeghi Florencia Schlamp Heather M. Holl Mohammad Moradi-Shahrbabak Seyed Reza Miraei-Ashtiani Salma Abdalla Ben Shykind Mats Troedsson Monika Stefaniuk-Szmukier Anil Prabhu Stefania Bucca Monika Bugno-Poniewierska Barbara Wallner Joel Malek Donald C. Miller Andrew G. Clark Douglas F. Antczak Samantha A. Brooks
author_facet	Elissa J. Cosgrove Raheleh Sadeghi Florencia Schlamp Heather M. Holl Mohammad Moradi-Shahrbabak Seyed Reza Miraei-Ashtiani Salma Abdalla Ben Shykind Mats Troedsson Monika Stefaniuk-Szmukier Anil Prabhu Stefania Bucca Monika Bugno-Poniewierska Barbara Wallner Joel Malek Donald C. Miller Andrew G. Clark Douglas F. Antczak Samantha A. Brooks
author_sort	Elissa J. Cosgrove
title	Genome Diversity and the Origin of the Arabian Horse
title_short	Genome Diversity and the Origin of the Arabian Horse
title_full	Genome Diversity and the Origin of the Arabian Horse
title_fullStr	Genome Diversity and the Origin of the Arabian Horse
title_full_unstemmed	Genome Diversity and the Origin of the Arabian Horse
title_sort	genome diversity and the origin of the arabian horse
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/859c1142aad7479ca7f2b0952b30f575
work_keys_str_mv	AT elissajcosgrove genomediversityandtheoriginofthearabianhorse AT rahelehsadeghi genomediversityandtheoriginofthearabianhorse AT florenciaschlamp genomediversityandtheoriginofthearabianhorse AT heathermholl genomediversityandtheoriginofthearabianhorse AT mohammadmoradishahrbabak genomediversityandtheoriginofthearabianhorse AT seyedrezamiraeiashtiani genomediversityandtheoriginofthearabianhorse AT salmaabdalla genomediversityandtheoriginofthearabianhorse AT benshykind genomediversityandtheoriginofthearabianhorse AT matstroedsson genomediversityandtheoriginofthearabianhorse AT monikastefaniukszmukier genomediversityandtheoriginofthearabianhorse AT anilprabhu genomediversityandtheoriginofthearabianhorse AT stefaniabucca genomediversityandtheoriginofthearabianhorse AT monikabugnoponiewierska genomediversityandtheoriginofthearabianhorse AT barbarawallner genomediversityandtheoriginofthearabianhorse AT joelmalek genomediversityandtheoriginofthearabianhorse AT donaldcmiller genomediversityandtheoriginofthearabianhorse AT andrewgclark genomediversityandtheoriginofthearabianhorse AT douglasfantczak genomediversityandtheoriginofthearabianhorse AT samanthaabrooks genomediversityandtheoriginofthearabianhorse
_version_	1718379773839802368

Genome Diversity and the Origin of the Arabian Horse

Ejemplares similares