Skin lesions in European hibernating bats associated with Geomyces destructans, the etiologic agent of white-nose syndrome.

White-nose syndrome (WNS) has claimed the lives of millions of hibernating insectivorous bats in North America. Its etiologic agent, the psychrophilic fungus Geomyces destructans, causes skin lesions that are the hallmark of the disease. The fungal infection is characterized by a white powdery growt...

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Autores principales:	Gudrun Wibbelt, Sébastien J Puechmaille, Bernd Ohlendorf, Kristin Mühldorfer, Thijs Bosch, Tamás Görföl, Karsten Passior, Andreas Kurth, Daniel Lacremans, Frédéric Forget
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/859d57e68520440fb8923a45dc3bf4c4
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spelling	oai:doaj.org-article:859d57e68520440fb8923a45dc3bf4c42021-11-18T08:56:53ZSkin lesions in European hibernating bats associated with Geomyces destructans, the etiologic agent of white-nose syndrome.1932-620310.1371/journal.pone.0074105https://doaj.org/article/859d57e68520440fb8923a45dc3bf4c42013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24023927/?tool=EBIhttps://doaj.org/toc/1932-6203White-nose syndrome (WNS) has claimed the lives of millions of hibernating insectivorous bats in North America. Its etiologic agent, the psychrophilic fungus Geomyces destructans, causes skin lesions that are the hallmark of the disease. The fungal infection is characterized by a white powdery growth on muzzle, ears and wing membranes. While WNS may threaten some species of North American bats with regional extinction, infection in hibernating bats in Europe seems not to be associated with significant mortality. We performed histopathological investigations on biopsy samples of 11 hibernating European bats, originating from 4 different countries, colonized by G. destructans. One additional bat was euthanized to allow thorough examination of multiple strips of its wing membranes. Molecular analyses of touch imprints, swabs and skin samples confirmed that fungal structures were G. destructans. Additionally, archived field notes on hibernacula monitoring data in the Harz Mountains, Germany, over an 11-year period (2000-2011) revealed multiple capture-recapture events of 8 banded bats repeatedly displaying characteristic fungal colonization. Skin lesions of G. destructans-affected hibernating European bats are intriguingly similar to the epidermal lesions described in North American bats. Nevertheless, deep invasion of fungal hyphae into the dermal connective tissue with resulting ulceration like in North American bats was not observed in the biopsy samples of European bats; all lesions found were restricted to the layers of the epidermis and its adnexae. Two bats had mild epidermal cupping erosions as described for North American bats. The possible mechanisms for any difference in outcomes of G. destructans infection in European and North American bats still need to be elucidated.Gudrun WibbeltSébastien J PuechmailleBernd OhlendorfKristin MühldorferThijs BoschTamás GörfölKarsten PassiorAndreas KurthDaniel LacremansFrédéric ForgetPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 9, p e74105 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Gudrun Wibbelt Sébastien J Puechmaille Bernd Ohlendorf Kristin Mühldorfer Thijs Bosch Tamás Görföl Karsten Passior Andreas Kurth Daniel Lacremans Frédéric Forget Skin lesions in European hibernating bats associated with Geomyces destructans, the etiologic agent of white-nose syndrome.
description	White-nose syndrome (WNS) has claimed the lives of millions of hibernating insectivorous bats in North America. Its etiologic agent, the psychrophilic fungus Geomyces destructans, causes skin lesions that are the hallmark of the disease. The fungal infection is characterized by a white powdery growth on muzzle, ears and wing membranes. While WNS may threaten some species of North American bats with regional extinction, infection in hibernating bats in Europe seems not to be associated with significant mortality. We performed histopathological investigations on biopsy samples of 11 hibernating European bats, originating from 4 different countries, colonized by G. destructans. One additional bat was euthanized to allow thorough examination of multiple strips of its wing membranes. Molecular analyses of touch imprints, swabs and skin samples confirmed that fungal structures were G. destructans. Additionally, archived field notes on hibernacula monitoring data in the Harz Mountains, Germany, over an 11-year period (2000-2011) revealed multiple capture-recapture events of 8 banded bats repeatedly displaying characteristic fungal colonization. Skin lesions of G. destructans-affected hibernating European bats are intriguingly similar to the epidermal lesions described in North American bats. Nevertheless, deep invasion of fungal hyphae into the dermal connective tissue with resulting ulceration like in North American bats was not observed in the biopsy samples of European bats; all lesions found were restricted to the layers of the epidermis and its adnexae. Two bats had mild epidermal cupping erosions as described for North American bats. The possible mechanisms for any difference in outcomes of G. destructans infection in European and North American bats still need to be elucidated.
format	article
author	Gudrun Wibbelt Sébastien J Puechmaille Bernd Ohlendorf Kristin Mühldorfer Thijs Bosch Tamás Görföl Karsten Passior Andreas Kurth Daniel Lacremans Frédéric Forget
author_facet	Gudrun Wibbelt Sébastien J Puechmaille Bernd Ohlendorf Kristin Mühldorfer Thijs Bosch Tamás Görföl Karsten Passior Andreas Kurth Daniel Lacremans Frédéric Forget
author_sort	Gudrun Wibbelt
title	Skin lesions in European hibernating bats associated with Geomyces destructans, the etiologic agent of white-nose syndrome.
title_short	Skin lesions in European hibernating bats associated with Geomyces destructans, the etiologic agent of white-nose syndrome.
title_full	Skin lesions in European hibernating bats associated with Geomyces destructans, the etiologic agent of white-nose syndrome.
title_fullStr	Skin lesions in European hibernating bats associated with Geomyces destructans, the etiologic agent of white-nose syndrome.
title_full_unstemmed	Skin lesions in European hibernating bats associated with Geomyces destructans, the etiologic agent of white-nose syndrome.
title_sort	skin lesions in european hibernating bats associated with geomyces destructans, the etiologic agent of white-nose syndrome.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/859d57e68520440fb8923a45dc3bf4c4
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Skin lesions in European hibernating bats associated with Geomyces destructans, the etiologic agent of white-nose syndrome.

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