EVALUATION OF T CELL IMMUNOLOGICAL MEMORY BY MEANS OF CD45+ EXPRESSION IN HUMANS VACCINATED WITH LIVE REASSORTANT INFLUENZA VACCINE

Abstract. A full-scale development of post-vaccinal immunity is determined by T and B cell-dependent immunological memory which is formed in response to vaccine injection. However, a capacity of existing and newly developed vaccines to stimulate T cell-dependent immunological memory is very poorly s...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	A. N. Naikhin, D. A. Koren’kov, G. D. Petukhova, T. V. Chirkova, E. P. Grigorieva, L. G. Rudenko
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immunological memory live influenza vaccine mucosal influenza vaccine сd45ro+ cd45ra+ cd4+сd45ro+ cd4+cd45ra+ cd8+сd45ro+ cd8+cd45ra+ Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/859dcdbd7dee4abeabe1c8163e10f594
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:859dcdbd7dee4abeabe1c8163e10f594
record_format	dspace
spelling	oai:doaj.org-article:859dcdbd7dee4abeabe1c8163e10f5942021-11-18T08:03:39ZEVALUATION OF T CELL IMMUNOLOGICAL MEMORY BY MEANS OF CD45+ EXPRESSION IN HUMANS VACCINATED WITH LIVE REASSORTANT INFLUENZA VACCINE1563-06252313-741X10.15789/1563-0625-2008-6-535-542https://doaj.org/article/859dcdbd7dee4abeabe1c8163e10f5942014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/262https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. A full-scale development of post-vaccinal immunity is determined by T and B cell-dependent immunological memory which is formed in response to vaccine injection. However, a capacity of existing and newly developed vaccines to stimulate T cell-dependent immunological memory is very poorly studied. Present work is a first attempt of analyzing this issue, with respect to effects of live mucosal influenza vaccine.The study involved fifty-seven healthy young persons, in whom percentage of T cells with СD45RO+, CD45RA+, CD4+СD45RO+, CD4+CD45RA+, CD8+СD45RO+, and CD8+CD45RA+ phenotypes was determined pre- and post-vaccination.Following vaccination, increased average T cell levels of all the mentioned phenotypes was revealed in those volunteers who responded to the vaccine with elevated serum antibody titers. Individual data analysis has shown that, among individuals with antibody response, a percentage of persons with CD45RO+ T cells was 35 to 57%, as compared to vaccinated persons without such antibody response (11 to 22%, p < 0.05; p < 0.01). When using CD45RA+ marker, appropriate values among group 1 volunteers varied between 14 and 36%, whereas for group 2, only one case was detected with expression with significantly increased CD8+CD45RA+, expression on T cells post-vaccination.Hence, a single immunization with live influenza vaccine is followed by significantly increased levels of peripheral CTLs (CD8+) and Th (СD4+) with СD45R0+ (memory cells) and СD45RА+ (naive) phenotypes in sufficient cohort of immunized persons (35 to 60%). Certain relations exist between post-vaccinal accumulation of memory T cells in peripheral blood, and development of a systemic humoral response to vaccination. However, this connection is not absolute, since an increase in these cells post-vaccination occurs in some persons without such a response (up to 25% of immunized individuals). (Med. Immunol., vol. 10, N 6, pp 535-542).A. N. NaikhinD. A. Koren’kovG. D. PetukhovaT. V. ChirkovaE. P. GrigorievaL. G. RudenkoSPb RAACIarticleimmunological memorylive influenza vaccinemucosal influenza vaccineсd45ro+cd45ra+cd4+сd45ro+cd4+cd45ra+cd8+сd45ro+cd8+cd45ra+Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 10, Iss 6, Pp 535-542 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunological memory live influenza vaccine mucosal influenza vaccine сd45ro+ cd45ra+ cd4+сd45ro+ cd4+cd45ra+ cd8+сd45ro+ cd8+cd45ra+ Immunologic diseases. Allergy RC581-607
spellingShingle	immunological memory live influenza vaccine mucosal influenza vaccine сd45ro+ cd45ra+ cd4+сd45ro+ cd4+cd45ra+ cd8+сd45ro+ cd8+cd45ra+ Immunologic diseases. Allergy RC581-607 A. N. Naikhin D. A. Koren’kov G. D. Petukhova T. V. Chirkova E. P. Grigorieva L. G. Rudenko EVALUATION OF T CELL IMMUNOLOGICAL MEMORY BY MEANS OF CD45+ EXPRESSION IN HUMANS VACCINATED WITH LIVE REASSORTANT INFLUENZA VACCINE
description	Abstract. A full-scale development of post-vaccinal immunity is determined by T and B cell-dependent immunological memory which is formed in response to vaccine injection. However, a capacity of existing and newly developed vaccines to stimulate T cell-dependent immunological memory is very poorly studied. Present work is a first attempt of analyzing this issue, with respect to effects of live mucosal influenza vaccine.The study involved fifty-seven healthy young persons, in whom percentage of T cells with СD45RO+, CD45RA+, CD4+СD45RO+, CD4+CD45RA+, CD8+СD45RO+, and CD8+CD45RA+ phenotypes was determined pre- and post-vaccination.Following vaccination, increased average T cell levels of all the mentioned phenotypes was revealed in those volunteers who responded to the vaccine with elevated serum antibody titers. Individual data analysis has shown that, among individuals with antibody response, a percentage of persons with CD45RO+ T cells was 35 to 57%, as compared to vaccinated persons without such antibody response (11 to 22%, p < 0.05; p < 0.01). When using CD45RA+ marker, appropriate values among group 1 volunteers varied between 14 and 36%, whereas for group 2, only one case was detected with expression with significantly increased CD8+CD45RA+, expression on T cells post-vaccination.Hence, a single immunization with live influenza vaccine is followed by significantly increased levels of peripheral CTLs (CD8+) and Th (СD4+) with СD45R0+ (memory cells) and СD45RА+ (naive) phenotypes in sufficient cohort of immunized persons (35 to 60%). Certain relations exist between post-vaccinal accumulation of memory T cells in peripheral blood, and development of a systemic humoral response to vaccination. However, this connection is not absolute, since an increase in these cells post-vaccination occurs in some persons without such a response (up to 25% of immunized individuals). (Med. Immunol., vol. 10, N 6, pp 535-542).
format	article
author	A. N. Naikhin D. A. Koren’kov G. D. Petukhova T. V. Chirkova E. P. Grigorieva L. G. Rudenko
author_facet	A. N. Naikhin D. A. Koren’kov G. D. Petukhova T. V. Chirkova E. P. Grigorieva L. G. Rudenko
author_sort	A. N. Naikhin
title	EVALUATION OF T CELL IMMUNOLOGICAL MEMORY BY MEANS OF CD45+ EXPRESSION IN HUMANS VACCINATED WITH LIVE REASSORTANT INFLUENZA VACCINE
title_short	EVALUATION OF T CELL IMMUNOLOGICAL MEMORY BY MEANS OF CD45+ EXPRESSION IN HUMANS VACCINATED WITH LIVE REASSORTANT INFLUENZA VACCINE
title_full	EVALUATION OF T CELL IMMUNOLOGICAL MEMORY BY MEANS OF CD45+ EXPRESSION IN HUMANS VACCINATED WITH LIVE REASSORTANT INFLUENZA VACCINE
title_fullStr	EVALUATION OF T CELL IMMUNOLOGICAL MEMORY BY MEANS OF CD45+ EXPRESSION IN HUMANS VACCINATED WITH LIVE REASSORTANT INFLUENZA VACCINE
title_full_unstemmed	EVALUATION OF T CELL IMMUNOLOGICAL MEMORY BY MEANS OF CD45+ EXPRESSION IN HUMANS VACCINATED WITH LIVE REASSORTANT INFLUENZA VACCINE
title_sort	evaluation of t cell immunological memory by means of cd45+ expression in humans vaccinated with live reassortant influenza vaccine
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/859dcdbd7dee4abeabe1c8163e10f594
work_keys_str_mv	AT annaikhin evaluationoftcellimmunologicalmemorybymeansofcd45expressioninhumansvaccinatedwithlivereassortantinfluenzavaccine AT dakorenkov evaluationoftcellimmunologicalmemorybymeansofcd45expressioninhumansvaccinatedwithlivereassortantinfluenzavaccine AT gdpetukhova evaluationoftcellimmunologicalmemorybymeansofcd45expressioninhumansvaccinatedwithlivereassortantinfluenzavaccine AT tvchirkova evaluationoftcellimmunologicalmemorybymeansofcd45expressioninhumansvaccinatedwithlivereassortantinfluenzavaccine AT epgrigorieva evaluationoftcellimmunologicalmemorybymeansofcd45expressioninhumansvaccinatedwithlivereassortantinfluenzavaccine AT lgrudenko evaluationoftcellimmunologicalmemorybymeansofcd45expressioninhumansvaccinatedwithlivereassortantinfluenzavaccine
_version_	1718422556242870272

EVALUATION OF T CELL IMMUNOLOGICAL MEMORY BY MEANS OF CD45+ EXPRESSION IN HUMANS VACCINATED WITH LIVE REASSORTANT INFLUENZA VACCINE

Ejemplares similares