Position sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide

Abstract Mood disorder is the leading intrinsic risk factor for suicidal ideation. Questioning any potency of mood-stabilizers, the monovalent cation lithium still holds the throne in medical psychiatric treatment. Furthermore, lithium`s anti-aggressive and suicide-preventive capacity in clinical pr...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	J. Schoepfer, R. Gernhäuser, S. Lichtinger, A. Stöver, M. Bendel, C. Delbridge, T. Widmann, S. Winkler, M. Graw
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/859fea33f5e648a39f5a6fcafebd5bbb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:859fea33f5e648a39f5a6fcafebd5bbb
record_format	dspace
spelling	oai:doaj.org-article:859fea33f5e648a39f5a6fcafebd5bbb2021-12-02T17:04:34ZPosition sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide10.1038/s41598-021-86377-x2045-2322https://doaj.org/article/859fea33f5e648a39f5a6fcafebd5bbb2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-86377-xhttps://doaj.org/toc/2045-2322Abstract Mood disorder is the leading intrinsic risk factor for suicidal ideation. Questioning any potency of mood-stabilizers, the monovalent cation lithium still holds the throne in medical psychiatric treatment. Furthermore, lithium`s anti-aggressive and suicide-preventive capacity in clinical practice is well established. But little is still known about trace lithium distribution and any associated metabolic effects in the human body. We applied a new technique (neutron-induced coincidence method “NIK”) utilizing the 6Li(n,α)3H reaction for the position sensitive, 3D spatially resolved detection of lithium traces in post-mortem human brain tissue in suicide versus control. NIK allowed, for the first time in lithium research, to collect a three dimensional high resolution map of the regional trace lithium content in the non lithium-medicated human brain. The results show an anisotropic distribution of lithium, thus indicating a homeostatic regulation under physiological conditions as a remarkable link to essentiality. In contrast to suicide we could empirically prove significantly higher endogenous lithium concentrations in white compared to gray matter as a general trend in non-suicidal individuals and lower lithium concentrations in emotion-modulating regions in suicide.J. SchoepferR. GernhäuserS. LichtingerA. StöverM. BendelC. DelbridgeT. WidmannS. WinklerM. GrawNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q J. Schoepfer R. Gernhäuser S. Lichtinger A. Stöver M. Bendel C. Delbridge T. Widmann S. Winkler M. Graw Position sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide
description	Abstract Mood disorder is the leading intrinsic risk factor for suicidal ideation. Questioning any potency of mood-stabilizers, the monovalent cation lithium still holds the throne in medical psychiatric treatment. Furthermore, lithium`s anti-aggressive and suicide-preventive capacity in clinical practice is well established. But little is still known about trace lithium distribution and any associated metabolic effects in the human body. We applied a new technique (neutron-induced coincidence method “NIK”) utilizing the 6Li(n,α)3H reaction for the position sensitive, 3D spatially resolved detection of lithium traces in post-mortem human brain tissue in suicide versus control. NIK allowed, for the first time in lithium research, to collect a three dimensional high resolution map of the regional trace lithium content in the non lithium-medicated human brain. The results show an anisotropic distribution of lithium, thus indicating a homeostatic regulation under physiological conditions as a remarkable link to essentiality. In contrast to suicide we could empirically prove significantly higher endogenous lithium concentrations in white compared to gray matter as a general trend in non-suicidal individuals and lower lithium concentrations in emotion-modulating regions in suicide.
format	article
author	J. Schoepfer R. Gernhäuser S. Lichtinger A. Stöver M. Bendel C. Delbridge T. Widmann S. Winkler M. Graw
author_facet	J. Schoepfer R. Gernhäuser S. Lichtinger A. Stöver M. Bendel C. Delbridge T. Widmann S. Winkler M. Graw
author_sort	J. Schoepfer
title	Position sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide
title_short	Position sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide
title_full	Position sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide
title_fullStr	Position sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide
title_full_unstemmed	Position sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide
title_sort	position sensitive measurement of trace lithium in the brain with nik (neutron-induced coincidence method) in suicide
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/859fea33f5e648a39f5a6fcafebd5bbb
work_keys_str_mv	AT jschoepfer positionsensitivemeasurementoftracelithiuminthebrainwithnikneutroninducedcoincidencemethodinsuicide AT rgernhauser positionsensitivemeasurementoftracelithiuminthebrainwithnikneutroninducedcoincidencemethodinsuicide AT slichtinger positionsensitivemeasurementoftracelithiuminthebrainwithnikneutroninducedcoincidencemethodinsuicide AT astover positionsensitivemeasurementoftracelithiuminthebrainwithnikneutroninducedcoincidencemethodinsuicide AT mbendel positionsensitivemeasurementoftracelithiuminthebrainwithnikneutroninducedcoincidencemethodinsuicide AT cdelbridge positionsensitivemeasurementoftracelithiuminthebrainwithnikneutroninducedcoincidencemethodinsuicide AT twidmann positionsensitivemeasurementoftracelithiuminthebrainwithnikneutroninducedcoincidencemethodinsuicide AT swinkler positionsensitivemeasurementoftracelithiuminthebrainwithnikneutroninducedcoincidencemethodinsuicide AT mgraw positionsensitivemeasurementoftracelithiuminthebrainwithnikneutroninducedcoincidencemethodinsuicide
_version_	1718381858934226944

Position sensitive measurement of trace lithium in the brain with NIK (neutron-induced coincidence method) in suicide

Ejemplares similares