Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase

Ethylene is a plant hormone that promotes fruit ripening. Here, the authors identify pyrazinamide, a drug used to treat tuberculosis, as an inhibitor of ethylene biosynthesis inArabidopsis thalianaand present the crystal structure of its active form (pyrazinecarboxylic acid) bound to ACC oxidase.

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Autores principales:	Xiangzhong Sun, Yaxin Li, Wenrong He, Chenggong Ji, Peixue Xia, Yichuan Wang, Shuo Du, Hongjiang Li, Natasha Raikhel, Junyu Xiao, Hongwei Guo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85a183370e27488bbd7ccf790f687158
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spelling	oai:doaj.org-article:85a183370e27488bbd7ccf790f6871582021-12-02T15:37:00ZPyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase10.1038/ncomms157582041-1723https://doaj.org/article/85a183370e27488bbd7ccf790f6871582017-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms15758https://doaj.org/toc/2041-1723Ethylene is a plant hormone that promotes fruit ripening. Here, the authors identify pyrazinamide, a drug used to treat tuberculosis, as an inhibitor of ethylene biosynthesis inArabidopsis thalianaand present the crystal structure of its active form (pyrazinecarboxylic acid) bound to ACC oxidase.Xiangzhong SunYaxin LiWenrong HeChenggong JiPeixue XiaYichuan WangShuo DuHongjiang LiNatasha RaikhelJunyu XiaoHongwei GuoNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Xiangzhong Sun Yaxin Li Wenrong He Chenggong Ji Peixue Xia Yichuan Wang Shuo Du Hongjiang Li Natasha Raikhel Junyu Xiao Hongwei Guo Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase
description	Ethylene is a plant hormone that promotes fruit ripening. Here, the authors identify pyrazinamide, a drug used to treat tuberculosis, as an inhibitor of ethylene biosynthesis inArabidopsis thalianaand present the crystal structure of its active form (pyrazinecarboxylic acid) bound to ACC oxidase.
format	article
author	Xiangzhong Sun Yaxin Li Wenrong He Chenggong Ji Peixue Xia Yichuan Wang Shuo Du Hongjiang Li Natasha Raikhel Junyu Xiao Hongwei Guo
author_facet	Xiangzhong Sun Yaxin Li Wenrong He Chenggong Ji Peixue Xia Yichuan Wang Shuo Du Hongjiang Li Natasha Raikhel Junyu Xiao Hongwei Guo
author_sort	Xiangzhong Sun
title	Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase
title_short	Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase
title_full	Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase
title_fullStr	Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase
title_full_unstemmed	Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase
title_sort	pyrazinamide and derivatives block ethylene biosynthesis by inhibiting acc oxidase
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/85a183370e27488bbd7ccf790f687158
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_version_	1718386299839184896

Pyrazinamide and derivatives block ethylene biosynthesis by inhibiting ACC oxidase

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