Age peculiarities in the change of aldoketoreductase spectrum in rat blood

In order to reveal the causes of age-related changes in sensitivity of the organism to oxidative stress, the spectrum of aldoketoreductases in blood serum of rats of different ages was investigated. It was discovered that 0.5- and 24-month old rats have the similar spectrum of aldoketoreductase in t...

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Autores principales:	V. V. Davydov, I. V. Matveeva, L. L. Sukhova
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	oxidative stress aldoketoreductase ontogenesis Science Q
Acceso en línea:	https://doaj.org/article/85a1fbd1e5574854a0694d5ca4ef9456
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spelling	oai:doaj.org-article:85a1fbd1e5574854a0694d5ca4ef94562021-11-23T06:14:34ZAge peculiarities in the change of aldoketoreductase spectrum in rat blood2541-94202587-959610.12737/article_590823a4c08831.87892379https://doaj.org/article/85a1fbd1e5574854a0694d5ca4ef94562016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/199https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596In order to reveal the causes of age-related changes in sensitivity of the organism to oxidative stress, the spectrum of aldoketoreductases in blood serum of rats of different ages was investigated. It was discovered that 0.5- and 24-month old rats have the similar spectrum of aldoketoreductase in the blood. There are only four electrophoretic fractions of aldoketoreductases in their spectrum. The share of 3rd fraction increases the spectrum of 1.5-, 2- and 3- month old rats. The pubertal rats contain additional 5th fraction in aldoketoreductase spectrum of the blood. This electrophoretic fraction has maximal electrophoretic mobility, but there is inconstancy in spectrum. There are 6 electrophoretic fractions of aldoketoreductases in the blood of 3-month old rats. Two of them with maximal electrophoretic mobility are absent in the spectrum of 0.5- and 24- month old rats. There are the same shares of 3rd and 4th fraction in the aldoketoreductase spectrum of the blood 12-month old rats, and 5th fraction there is inconstancy. The cause of age-related changes in the aldoketoreductase spectrum of blood may be coupled with existence of age-related differences in the gene expression of the encoded enzymes of aldoketoreductase family. Due to the fact that 0.5- (early childhood) and 24-month old (senescence) rats have similar aldoketoreductase spectrum of the blood, we propose that the cause ofthat phenomenon coupled with age-related changes in the production and secretion of sex steroids.V. V. DavydovI. V. MatveevaL. L. SukhovaScientific Сentre for Family Health and Human Reproduction Problemsarticleoxidative stressaldoketoreductaseontogenesisScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 109-111 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	oxidative stress aldoketoreductase ontogenesis Science Q
spellingShingle	oxidative stress aldoketoreductase ontogenesis Science Q V. V. Davydov I. V. Matveeva L. L. Sukhova Age peculiarities in the change of aldoketoreductase spectrum in rat blood
description	In order to reveal the causes of age-related changes in sensitivity of the organism to oxidative stress, the spectrum of aldoketoreductases in blood serum of rats of different ages was investigated. It was discovered that 0.5- and 24-month old rats have the similar spectrum of aldoketoreductase in the blood. There are only four electrophoretic fractions of aldoketoreductases in their spectrum. The share of 3rd fraction increases the spectrum of 1.5-, 2- and 3- month old rats. The pubertal rats contain additional 5th fraction in aldoketoreductase spectrum of the blood. This electrophoretic fraction has maximal electrophoretic mobility, but there is inconstancy in spectrum. There are 6 electrophoretic fractions of aldoketoreductases in the blood of 3-month old rats. Two of them with maximal electrophoretic mobility are absent in the spectrum of 0.5- and 24- month old rats. There are the same shares of 3rd and 4th fraction in the aldoketoreductase spectrum of the blood 12-month old rats, and 5th fraction there is inconstancy. The cause of age-related changes in the aldoketoreductase spectrum of blood may be coupled with existence of age-related differences in the gene expression of the encoded enzymes of aldoketoreductase family. Due to the fact that 0.5- (early childhood) and 24-month old (senescence) rats have similar aldoketoreductase spectrum of the blood, we propose that the cause ofthat phenomenon coupled with age-related changes in the production and secretion of sex steroids.
format	article
author	V. V. Davydov I. V. Matveeva L. L. Sukhova
author_facet	V. V. Davydov I. V. Matveeva L. L. Sukhova
author_sort	V. V. Davydov
title	Age peculiarities in the change of aldoketoreductase spectrum in rat blood
title_short	Age peculiarities in the change of aldoketoreductase spectrum in rat blood
title_full	Age peculiarities in the change of aldoketoreductase spectrum in rat blood
title_fullStr	Age peculiarities in the change of aldoketoreductase spectrum in rat blood
title_full_unstemmed	Age peculiarities in the change of aldoketoreductase spectrum in rat blood
title_sort	age peculiarities in the change of aldoketoreductase spectrum in rat blood
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/85a1fbd1e5574854a0694d5ca4ef9456
work_keys_str_mv	AT vvdavydov agepeculiaritiesinthechangeofaldoketoreductasespectruminratblood AT ivmatveeva agepeculiaritiesinthechangeofaldoketoreductasespectruminratblood AT llsukhova agepeculiaritiesinthechangeofaldoketoreductasespectruminratblood
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Age peculiarities in the change of aldoketoreductase spectrum in rat blood

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