Targeting stem cells in the realm of drug-resistant breast cancer

Pranay Dey,1,2 Maitreyi Rathod,1,2 Abhijit De1,2 1Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India; 2Molecular Functional Imaging Lab, Homi Bhabha National Institute, Mumbai, India Abstract: Since its first do...

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Autores principales:	Dey P, Rathod M, De A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	Chemoresistance Cancer stem cell (CSC) Tumor microenvironment Breast Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/85a270005272486a985242bd44df587c
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spelling	oai:doaj.org-article:85a270005272486a985242bd44df587c2021-12-02T03:12:22ZTargeting stem cells in the realm of drug-resistant breast cancer1179-1314https://doaj.org/article/85a270005272486a985242bd44df587c2019-03-01T00:00:00Zhttps://www.dovepress.com/targeting-stem-cells-in-the-realm-of-drug-resistant-breast-cancer-peer-reviewed-article-BCTThttps://doaj.org/toc/1179-1314Pranay Dey,1,2 Maitreyi Rathod,1,2 Abhijit De1,2 1Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India; 2Molecular Functional Imaging Lab, Homi Bhabha National Institute, Mumbai, India Abstract: Since its first documentation, breast cancer (BC) has been a conundrum that ails millions of women every year. This cancer has been well studied by researchers all over the world, which has improved the patient outcome significantly. There are many diagnostic markers to identify the disease, but early detection and then subclassification of this cancer remain dubious. Even after the correct diagnosis, more than half the patients come back with a more aggressive and metastatic tumor. The underpinning mechanism that governs the resistance includes over-amplification of receptors, mutations in key gene targets, and activation of different signaling. A plethora of drugs have been devised that have shown promising results in clinical settings. However, in recent times, the role played by cancer stem cells in disease progression and their interaction in mediating the resistance to cellular insults have come into the limelight. As breast cancer stem cells (BCSCs) are dormant in nature, it is highly likely that they fail to directly respond to the cytotoxic drugs which are meant for ablating rapidly proliferating cells. Furthermore, the absence of well-characterized, drug-able surface markers to date, has limited the application of targeted therapies in complete eradication of the disease. In this review, our intent is to discuss versatile therapeutics in practice followed by discussing the upcoming therapy strategies in the pipeline for BC. Furthermore, we focus on the roles played by BCSCs in mediating the resistance, and therefore, the aspects of new therapeutics against BCSCs under development that may ease the burden in future has also been discussed. Keywords: chemoresistance, cancer stem cell, BCSC, tumor microenvironment, breast cancer, conventional therapies, TRAIL therapyDey PRathod MDe ADove Medical PressarticleChemoresistanceCancer stem cell (CSC)Tumor microenvironmentBreast CancerNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBreast Cancer: Targets and Therapy, Vol Volume 11, Pp 115-135 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chemoresistance Cancer stem cell (CSC) Tumor microenvironment Breast Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Chemoresistance Cancer stem cell (CSC) Tumor microenvironment Breast Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Dey P Rathod M De A Targeting stem cells in the realm of drug-resistant breast cancer
description	Pranay Dey,1,2 Maitreyi Rathod,1,2 Abhijit De1,2 1Molecular Functional Imaging Lab, Advanced Centre for Treatment, Research and Education in Cancer, Tata Memorial Centre, Navi Mumbai, India; 2Molecular Functional Imaging Lab, Homi Bhabha National Institute, Mumbai, India Abstract: Since its first documentation, breast cancer (BC) has been a conundrum that ails millions of women every year. This cancer has been well studied by researchers all over the world, which has improved the patient outcome significantly. There are many diagnostic markers to identify the disease, but early detection and then subclassification of this cancer remain dubious. Even after the correct diagnosis, more than half the patients come back with a more aggressive and metastatic tumor. The underpinning mechanism that governs the resistance includes over-amplification of receptors, mutations in key gene targets, and activation of different signaling. A plethora of drugs have been devised that have shown promising results in clinical settings. However, in recent times, the role played by cancer stem cells in disease progression and their interaction in mediating the resistance to cellular insults have come into the limelight. As breast cancer stem cells (BCSCs) are dormant in nature, it is highly likely that they fail to directly respond to the cytotoxic drugs which are meant for ablating rapidly proliferating cells. Furthermore, the absence of well-characterized, drug-able surface markers to date, has limited the application of targeted therapies in complete eradication of the disease. In this review, our intent is to discuss versatile therapeutics in practice followed by discussing the upcoming therapy strategies in the pipeline for BC. Furthermore, we focus on the roles played by BCSCs in mediating the resistance, and therefore, the aspects of new therapeutics against BCSCs under development that may ease the burden in future has also been discussed. Keywords: chemoresistance, cancer stem cell, BCSC, tumor microenvironment, breast cancer, conventional therapies, TRAIL therapy
format	article
author	Dey P Rathod M De A
author_facet	Dey P Rathod M De A
author_sort	Dey P
title	Targeting stem cells in the realm of drug-resistant breast cancer
title_short	Targeting stem cells in the realm of drug-resistant breast cancer
title_full	Targeting stem cells in the realm of drug-resistant breast cancer
title_fullStr	Targeting stem cells in the realm of drug-resistant breast cancer
title_full_unstemmed	Targeting stem cells in the realm of drug-resistant breast cancer
title_sort	targeting stem cells in the realm of drug-resistant breast cancer
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/85a270005272486a985242bd44df587c
work_keys_str_mv	AT deyp targetingstemcellsintherealmofdrugresistantbreastcancer AT rathodm targetingstemcellsintherealmofdrugresistantbreastcancer AT dea targetingstemcellsintherealmofdrugresistantbreastcancer
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Targeting stem cells in the realm of drug-resistant breast cancer

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