Voltage-gated sodium channels assemble and gate as dimers

Voltage-gated sodium channels assemble and gate as dimers

Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this functional dimerisation is conserved.

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Autores principales: Jérôme Clatot, Malcolm Hoshi, Xiaoping Wan, Haiyan Liu, Ankur Jain, Krekwit Shinlapawittayatorn, Céline Marionneau, Eckhard Ficker, Taekjip Ha, Isabelle Deschênes
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/85a3e4c0115748e58575917074c2df76
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spelling oai:doaj.org-article:85a3e4c0115748e58575917074c2df762021-12-02T15:38:32ZVoltage-gated sodium channels assemble and gate as dimers10.1038/s41467-017-02262-02041-1723https://doaj.org/article/85a3e4c0115748e58575917074c2df762017-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-02262-0https://doaj.org/toc/2041-1723Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this functional dimerisation is conserved.Jérôme ClatotMalcolm HoshiXiaoping WanHaiyan LiuAnkur JainKrekwit ShinlapawittayatornCéline MarionneauEckhard FickerTaekjip HaIsabelle DeschênesNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Jérôme Clatot
Malcolm Hoshi
Xiaoping Wan
Haiyan Liu
Ankur Jain
Krekwit Shinlapawittayatorn
Céline Marionneau
Eckhard Ficker
Taekjip Ha
Isabelle Deschênes
Voltage-gated sodium channels assemble and gate as dimers
description Voltage-gated sodium channels are expressed in excitable tissues and mutations have been linked to cardiac arrhythmias and channelopathies. Here the authors show that the sodium channel α-subunits interact to form a dimer and gate as dimer and that this functional dimerisation is conserved.
format article
author Jérôme Clatot
Malcolm Hoshi
Xiaoping Wan
Haiyan Liu
Ankur Jain
Krekwit Shinlapawittayatorn
Céline Marionneau
Eckhard Ficker
Taekjip Ha
Isabelle Deschênes
author_facet Jérôme Clatot
Malcolm Hoshi
Xiaoping Wan
Haiyan Liu
Ankur Jain
Krekwit Shinlapawittayatorn
Céline Marionneau
Eckhard Ficker
Taekjip Ha
Isabelle Deschênes
author_sort Jérôme Clatot
title Voltage-gated sodium channels assemble and gate as dimers
title_short Voltage-gated sodium channels assemble and gate as dimers
title_full Voltage-gated sodium channels assemble and gate as dimers
title_fullStr Voltage-gated sodium channels assemble and gate as dimers
title_full_unstemmed Voltage-gated sodium channels assemble and gate as dimers
title_sort voltage-gated sodium channels assemble and gate as dimers
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/85a3e4c0115748e58575917074c2df76
work_keys_str_mv AT jeromeclatot voltagegatedsodiumchannelsassembleandgateasdimers
AT malcolmhoshi voltagegatedsodiumchannelsassembleandgateasdimers
AT xiaopingwan voltagegatedsodiumchannelsassembleandgateasdimers
AT haiyanliu voltagegatedsodiumchannelsassembleandgateasdimers
AT ankurjain voltagegatedsodiumchannelsassembleandgateasdimers
AT krekwitshinlapawittayatorn voltagegatedsodiumchannelsassembleandgateasdimers
AT celinemarionneau voltagegatedsodiumchannelsassembleandgateasdimers
AT eckhardficker voltagegatedsodiumchannelsassembleandgateasdimers
AT taekjipha voltagegatedsodiumchannelsassembleandgateasdimers
AT isabelledeschenes voltagegatedsodiumchannelsassembleandgateasdimers
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