Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

Here, the authors show that microglia depletion results in unstable wakefulness and altered levels of ceramide, influencing microglia in the mouse thalamic reticular nucleus (TRN). Stable wakefulness can be restored by activation of the TRN or inhibition of ceramide production in the mouse brain.

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Autores principales:	Hanxiao Liu, Xinxing Wang, Lu Chen, Liang Chen, Stella E. Tsirka, Shaoyu Ge, Qiaojie Xiong
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85a4e328c23d4b989f9a8c639753deae
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spelling	oai:doaj.org-article:85a4e328c23d4b989f9a8c639753deae2021-12-02T16:13:56ZMicroglia modulate stable wakefulness via the thalamic reticular nucleus in mice10.1038/s41467-021-24915-x2041-1723https://doaj.org/article/85a4e328c23d4b989f9a8c639753deae2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24915-xhttps://doaj.org/toc/2041-1723Here, the authors show that microglia depletion results in unstable wakefulness and altered levels of ceramide, influencing microglia in the mouse thalamic reticular nucleus (TRN). Stable wakefulness can be restored by activation of the TRN or inhibition of ceramide production in the mouse brain.Hanxiao LiuXinxing WangLu ChenLiang ChenStella E. TsirkaShaoyu GeQiaojie XiongNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hanxiao Liu Xinxing Wang Lu Chen Liang Chen Stella E. Tsirka Shaoyu Ge Qiaojie Xiong Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
description	Here, the authors show that microglia depletion results in unstable wakefulness and altered levels of ceramide, influencing microglia in the mouse thalamic reticular nucleus (TRN). Stable wakefulness can be restored by activation of the TRN or inhibition of ceramide production in the mouse brain.
format	article
author	Hanxiao Liu Xinxing Wang Lu Chen Liang Chen Stella E. Tsirka Shaoyu Ge Qiaojie Xiong
author_facet	Hanxiao Liu Xinxing Wang Lu Chen Liang Chen Stella E. Tsirka Shaoyu Ge Qiaojie Xiong
author_sort	Hanxiao Liu
title	Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
title_short	Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
title_full	Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
title_fullStr	Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
title_full_unstemmed	Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
title_sort	microglia modulate stable wakefulness via the thalamic reticular nucleus in mice
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/85a4e328c23d4b989f9a8c639753deae
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Microglia modulate stable wakefulness via the thalamic reticular nucleus in mice

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