Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study.

The aim of this study was to examine the risk of falls associated with the use of non-gamma amino butyric acid (GABA) sleep medications, suvorexant and ramelteon. This case-control and case-crossover study was performed at the Kudanzaka Hospital, Chiyoda Ward, Tokyo. A total of 325 patients who had...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yoshiki Ishibashi, Rie Nishitani, Akiyoshi Shimura, Ayano Takeuchi, Mamoru Touko, Takashi Kato, Sahoko Chiba, Keiko Ashidate, Nobuo Ishiwata, Tomoyasu Ichijo, Masataka Sasabe
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/85a560f2e45f434a97ec2e216843e298
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:85a560f2e45f434a97ec2e216843e298
record_format	dspace
spelling	oai:doaj.org-article:85a560f2e45f434a97ec2e216843e2982021-12-02T20:11:28ZNon-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study.1932-620310.1371/journal.pone.0238723https://doaj.org/article/85a560f2e45f434a97ec2e216843e2982020-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0238723https://doaj.org/toc/1932-6203The aim of this study was to examine the risk of falls associated with the use of non-gamma amino butyric acid (GABA) sleep medications, suvorexant and ramelteon. This case-control and case-crossover study was performed at the Kudanzaka Hospital, Chiyoda Ward, Tokyo. A total of 325 patients who had falls and 1295 controls matched by sex and age were included. The inclusion criteria for the case group were hospitalized patients who had their first fall and that for the control were patients who were hospitalized and did not have a fall, between January 2016 and November 2018. The internal sleep medications administered were classified as suvorexant, ramelteon, non-benzodiazepines, benzodiazepines, or kampo. In the case-control study, age, sex, clinical department, the fall down risk score, and hospitalized duration were adjusted in the logistic regression model. In the case-control study, multivariable logistic regression showed that the use of suvorexant (odds ratio [OR]: 2.61, 95% confidence interval [CI]: 1.29-5.28), nonbenzodiazepines (OR: 2.49, 95% CI: 1.73-3.59), and benzodiazepines (OR: 1.65, 95% CI: 1.16-2.34) was significantly associated with an increased OR of falls. However, the use of ramelteon (OR: 1.40, 95% CI: 0.60-3.16) and kampo (OR: 1.55, 95% CI: 0.75-3.19) was not significantly associated with an increased OR of falls. In the case-crossover study, the use of suvorexant (OR: 1.78, 95% CI: 1.05-3.00) and nonbenzodiazepines (OR: 1.63, 95% CI: 1.17-2.27) was significantly associated with an increased OR of falls. Similar patterns were observed in several sensitivity analyses. It was suggested that suvorexant increases the OR of falls. This result is robust in various analyses. This study showed that the risk of falls also exists for non-GABA sleep medication, suvorexant, and thus it is necessary to carefully prescribe hypnotic drugs under appropriate assessment.Yoshiki IshibashiRie NishitaniAkiyoshi ShimuraAyano TakeuchiMamoru ToukoTakashi KatoSahoko ChibaKeiko AshidateNobuo IshiwataTomoyasu IchijoMasataka SasabePublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 15, Iss 9, p e0238723 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yoshiki Ishibashi Rie Nishitani Akiyoshi Shimura Ayano Takeuchi Mamoru Touko Takashi Kato Sahoko Chiba Keiko Ashidate Nobuo Ishiwata Tomoyasu Ichijo Masataka Sasabe Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study.
description	The aim of this study was to examine the risk of falls associated with the use of non-gamma amino butyric acid (GABA) sleep medications, suvorexant and ramelteon. This case-control and case-crossover study was performed at the Kudanzaka Hospital, Chiyoda Ward, Tokyo. A total of 325 patients who had falls and 1295 controls matched by sex and age were included. The inclusion criteria for the case group were hospitalized patients who had their first fall and that for the control were patients who were hospitalized and did not have a fall, between January 2016 and November 2018. The internal sleep medications administered were classified as suvorexant, ramelteon, non-benzodiazepines, benzodiazepines, or kampo. In the case-control study, age, sex, clinical department, the fall down risk score, and hospitalized duration were adjusted in the logistic regression model. In the case-control study, multivariable logistic regression showed that the use of suvorexant (odds ratio [OR]: 2.61, 95% confidence interval [CI]: 1.29-5.28), nonbenzodiazepines (OR: 2.49, 95% CI: 1.73-3.59), and benzodiazepines (OR: 1.65, 95% CI: 1.16-2.34) was significantly associated with an increased OR of falls. However, the use of ramelteon (OR: 1.40, 95% CI: 0.60-3.16) and kampo (OR: 1.55, 95% CI: 0.75-3.19) was not significantly associated with an increased OR of falls. In the case-crossover study, the use of suvorexant (OR: 1.78, 95% CI: 1.05-3.00) and nonbenzodiazepines (OR: 1.63, 95% CI: 1.17-2.27) was significantly associated with an increased OR of falls. Similar patterns were observed in several sensitivity analyses. It was suggested that suvorexant increases the OR of falls. This result is robust in various analyses. This study showed that the risk of falls also exists for non-GABA sleep medication, suvorexant, and thus it is necessary to carefully prescribe hypnotic drugs under appropriate assessment.
format	article
author	Yoshiki Ishibashi Rie Nishitani Akiyoshi Shimura Ayano Takeuchi Mamoru Touko Takashi Kato Sahoko Chiba Keiko Ashidate Nobuo Ishiwata Tomoyasu Ichijo Masataka Sasabe
author_facet	Yoshiki Ishibashi Rie Nishitani Akiyoshi Shimura Ayano Takeuchi Mamoru Touko Takashi Kato Sahoko Chiba Keiko Ashidate Nobuo Ishiwata Tomoyasu Ichijo Masataka Sasabe
author_sort	Yoshiki Ishibashi
title	Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study.
title_short	Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study.
title_full	Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study.
title_fullStr	Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study.
title_full_unstemmed	Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study.
title_sort	non-gaba sleep medications, suvorexant as risk factors for falls: case-control and case-crossover study.
publisher	Public Library of Science (PLoS)
publishDate	2020
url	https://doaj.org/article/85a560f2e45f434a97ec2e216843e298
work_keys_str_mv	AT yoshikiishibashi nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy AT rienishitani nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy AT akiyoshishimura nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy AT ayanotakeuchi nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy AT mamorutouko nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy AT takashikato nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy AT sahokochiba nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy AT keikoashidate nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy AT nobuoishiwata nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy AT tomoyasuichijo nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy AT masatakasasabe nongabasleepmedicationssuvorexantasriskfactorsforfallscasecontrolandcasecrossoverstudy
_version_	1718374895684943872

Non-GABA sleep medications, suvorexant as risk factors for falls: Case-control and case-crossover study.

Ejemplares similares