Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction

Glioblastoma represents the most devastating form of human brain cancer, associated with a very poor survival rate of patients. Unfortunately, treatment options are currently limited and the gold standard pharmacological treatment with the chemotherapeutic drug temozolomide only slightly increases t...

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Autores principales:	Marc Dahlmanns, Eduard Yakubov, Jana Katharina Dahlmanns
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	ferroptosis neuroblastoma glioblastoma erastin neuron xCT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/85a6ad0a3cb8479790113f87b4c61a31
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spelling	oai:doaj.org-article:85a6ad0a3cb8479790113f87b4c61a312021-12-01T22:17:40ZGenetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction2234-943X10.3389/fonc.2021.783067https://doaj.org/article/85a6ad0a3cb8479790113f87b4c61a312021-12-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.783067/fullhttps://doaj.org/toc/2234-943XGlioblastoma represents the most devastating form of human brain cancer, associated with a very poor survival rate of patients. Unfortunately, treatment options are currently limited and the gold standard pharmacological treatment with the chemotherapeutic drug temozolomide only slightly increases the survival rate. Experimental studies have shown that the efficiency of temozolomide can be improved by inducing ferroptosis – a recently discovered form of cell death, which is different from apoptosis, necrosis, or necroptosis and, which is characterized by lipid peroxidation and reactive oxygen species accumulation. Ferroptosis can also be activated to improve treatment of malignant stages of neuroblastoma, meningioma, and glioma. Due to their role in cancer treatment, ferroptosis-gene signatures have recently been evaluated for their ability to predict survival of patients. Despite positive effects during chemotherapy, the drugs used to induce ferroptosis – such as erastin and sorafenib – as well as genetic manipulation of key players in ferroptosis – such as the cystine-glutamate exchanger xCT and the glutathione peroxidase GPx4 – also impact neuronal function and cognitive capabilities. In this review, we give an update on ferroptosis in different brain tumors and summarize the impact of ferroptosis on healthy tissues.Marc DahlmannsEduard YakubovJana Katharina DahlmannsFrontiers Media S.A.articleferroptosisneuroblastomaglioblastomaerastinneuronxCTNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ferroptosis neuroblastoma glioblastoma erastin neuron xCT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	ferroptosis neuroblastoma glioblastoma erastin neuron xCT Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Marc Dahlmanns Eduard Yakubov Jana Katharina Dahlmanns Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction
description	Glioblastoma represents the most devastating form of human brain cancer, associated with a very poor survival rate of patients. Unfortunately, treatment options are currently limited and the gold standard pharmacological treatment with the chemotherapeutic drug temozolomide only slightly increases the survival rate. Experimental studies have shown that the efficiency of temozolomide can be improved by inducing ferroptosis – a recently discovered form of cell death, which is different from apoptosis, necrosis, or necroptosis and, which is characterized by lipid peroxidation and reactive oxygen species accumulation. Ferroptosis can also be activated to improve treatment of malignant stages of neuroblastoma, meningioma, and glioma. Due to their role in cancer treatment, ferroptosis-gene signatures have recently been evaluated for their ability to predict survival of patients. Despite positive effects during chemotherapy, the drugs used to induce ferroptosis – such as erastin and sorafenib – as well as genetic manipulation of key players in ferroptosis – such as the cystine-glutamate exchanger xCT and the glutathione peroxidase GPx4 – also impact neuronal function and cognitive capabilities. In this review, we give an update on ferroptosis in different brain tumors and summarize the impact of ferroptosis on healthy tissues.
format	article
author	Marc Dahlmanns Eduard Yakubov Jana Katharina Dahlmanns
author_facet	Marc Dahlmanns Eduard Yakubov Jana Katharina Dahlmanns
author_sort	Marc Dahlmanns
title	Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction
title_short	Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction
title_full	Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction
title_fullStr	Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction
title_full_unstemmed	Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction
title_sort	genetic profiles of ferroptosis in malignant brain tumors and off-target effects of ferroptosis induction
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/85a6ad0a3cb8479790113f87b4c61a31
work_keys_str_mv	AT marcdahlmanns geneticprofilesofferroptosisinmalignantbraintumorsandofftargeteffectsofferroptosisinduction AT eduardyakubov geneticprofilesofferroptosisinmalignantbraintumorsandofftargeteffectsofferroptosisinduction AT janakatharinadahlmanns geneticprofilesofferroptosisinmalignantbraintumorsandofftargeteffectsofferroptosisinduction
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Genetic Profiles of Ferroptosis in Malignant Brain Tumors and Off-Target Effects of Ferroptosis Induction

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