Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness

2014 marked the first emergence of avian influenza A(H5N8) in Jeonbuk Province, South Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak, it spread to domestic poultry and wild waterfowl shorebirds, leading to the first human infection in Astrakhan Oblast, Russia...

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Autores principales:	Joshua Yi Yeo, Samuel Ken-En Gan
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	H5N8 influenza virus antiviral mutation reassortment Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/85aa55cab2f64ec08b3436cb1a1f9007
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spelling	oai:doaj.org-article:85aa55cab2f64ec08b3436cb1a1f90072021-11-25T19:14:01ZPeering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness10.3390/v131122761999-4915https://doaj.org/article/85aa55cab2f64ec08b3436cb1a1f90072021-11-01T00:00:00Zhttps://www.mdpi.com/1999-4915/13/11/2276https://doaj.org/toc/1999-49152014 marked the first emergence of avian influenza A(H5N8) in Jeonbuk Province, South Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak, it spread to domestic poultry and wild waterfowl shorebirds, leading to the first human infection in Astrakhan Oblast, Russia. Despite being clinically asymptomatic and without direct human-to-human transmission, the World Health Organization stressed the need for continued risk assessment given the nature of Influenza to reassort and generate novel strains. Given its promiscuity and easy cross to humans, the urgency to understand the mechanisms of possible species jumping to avert disastrous pandemics is increasing. Addressing the epidemiology of H5N8, its mechanisms of species jumping and its implications, mutational and reassortment libraries can potentially be built, allowing them to be tested on various models complemented with deep-sequencing and automation. With knowledge on mutational patterns, cellular pathways, drug resistance mechanisms and effects of host proteins, we can be better prepared against H5N8 and other influenza A viruses.Joshua Yi YeoSamuel Ken-En GanMDPI AGarticleH5N8influenzavirusantiviralmutationreassortmentMicrobiologyQR1-502ENViruses, Vol 13, Iss 2276, p 2276 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	H5N8 influenza virus antiviral mutation reassortment Microbiology QR1-502
spellingShingle	H5N8 influenza virus antiviral mutation reassortment Microbiology QR1-502 Joshua Yi Yeo Samuel Ken-En Gan Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness
description	2014 marked the first emergence of avian influenza A(H5N8) in Jeonbuk Province, South Korea, which then quickly spread worldwide. In the midst of the 2020–2021 H5N8 outbreak, it spread to domestic poultry and wild waterfowl shorebirds, leading to the first human infection in Astrakhan Oblast, Russia. Despite being clinically asymptomatic and without direct human-to-human transmission, the World Health Organization stressed the need for continued risk assessment given the nature of Influenza to reassort and generate novel strains. Given its promiscuity and easy cross to humans, the urgency to understand the mechanisms of possible species jumping to avert disastrous pandemics is increasing. Addressing the epidemiology of H5N8, its mechanisms of species jumping and its implications, mutational and reassortment libraries can potentially be built, allowing them to be tested on various models complemented with deep-sequencing and automation. With knowledge on mutational patterns, cellular pathways, drug resistance mechanisms and effects of host proteins, we can be better prepared against H5N8 and other influenza A viruses.
format	article
author	Joshua Yi Yeo Samuel Ken-En Gan
author_facet	Joshua Yi Yeo Samuel Ken-En Gan
author_sort	Joshua Yi Yeo
title	Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness
title_short	Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness
title_full	Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness
title_fullStr	Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness
title_full_unstemmed	Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness
title_sort	peering into avian influenza a(h5n8) for a framework towards pandemic preparedness
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/85aa55cab2f64ec08b3436cb1a1f9007
work_keys_str_mv	AT joshuayiyeo peeringintoavianinfluenzaah5n8foraframeworktowardspandemicpreparedness AT samuelkenengan peeringintoavianinfluenzaah5n8foraframeworktowardspandemicpreparedness
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Peering into Avian Influenza A(H5N8) for a Framework towards Pandemic Preparedness

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