UPF1-like helicase grip on nucleic acids dictates processivity

UPF1 is a highly processive helicase that plays an essential role in nonsense-mediated mRNA decay. Here the authors use single molecule binding assays to establish a functionally important relationship between helicase grip to nucleic acids, binding lifetime and the duration of translocation.

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Autores principales:	Joanne Kanaan, Saurabh Raj, Laurence Decourty, Cosmin Saveanu, Vincent Croquette, Hervé Le Hir
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85ab4400a2f146e49bce2617f7651da0
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spelling	oai:doaj.org-article:85ab4400a2f146e49bce2617f7651da02021-12-02T15:34:44ZUPF1-like helicase grip on nucleic acids dictates processivity10.1038/s41467-018-06313-y2041-1723https://doaj.org/article/85ab4400a2f146e49bce2617f7651da02018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06313-yhttps://doaj.org/toc/2041-1723UPF1 is a highly processive helicase that plays an essential role in nonsense-mediated mRNA decay. Here the authors use single molecule binding assays to establish a functionally important relationship between helicase grip to nucleic acids, binding lifetime and the duration of translocation.Joanne KanaanSaurabh RajLaurence DecourtyCosmin SaveanuVincent CroquetteHervé Le HirNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-9 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joanne Kanaan Saurabh Raj Laurence Decourty Cosmin Saveanu Vincent Croquette Hervé Le Hir UPF1-like helicase grip on nucleic acids dictates processivity
description	UPF1 is a highly processive helicase that plays an essential role in nonsense-mediated mRNA decay. Here the authors use single molecule binding assays to establish a functionally important relationship between helicase grip to nucleic acids, binding lifetime and the duration of translocation.
format	article
author	Joanne Kanaan Saurabh Raj Laurence Decourty Cosmin Saveanu Vincent Croquette Hervé Le Hir
author_facet	Joanne Kanaan Saurabh Raj Laurence Decourty Cosmin Saveanu Vincent Croquette Hervé Le Hir
author_sort	Joanne Kanaan
title	UPF1-like helicase grip on nucleic acids dictates processivity
title_short	UPF1-like helicase grip on nucleic acids dictates processivity
title_full	UPF1-like helicase grip on nucleic acids dictates processivity
title_fullStr	UPF1-like helicase grip on nucleic acids dictates processivity
title_full_unstemmed	UPF1-like helicase grip on nucleic acids dictates processivity
title_sort	upf1-like helicase grip on nucleic acids dictates processivity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/85ab4400a2f146e49bce2617f7651da0
work_keys_str_mv	AT joannekanaan upf1likehelicasegriponnucleicacidsdictatesprocessivity AT saurabhraj upf1likehelicasegriponnucleicacidsdictatesprocessivity AT laurencedecourty upf1likehelicasegriponnucleicacidsdictatesprocessivity AT cosminsaveanu upf1likehelicasegriponnucleicacidsdictatesprocessivity AT vincentcroquette upf1likehelicasegriponnucleicacidsdictatesprocessivity AT hervelehir upf1likehelicasegriponnucleicacidsdictatesprocessivity
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UPF1-like helicase grip on nucleic acids dictates processivity

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