Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

While mechanisms have been proposed for the prebiotic nucleotide synthesis, these require separate (and potentially incompatible) routes for pyrimidines and purines. Here the authors show that both of these classes of molecules can be formed by a divergent synthesis from a common prebiotic precursor...

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Autores principales:	Shaun Stairs, Arif Nikmal, Dejan-Krešimir Bučar, Shao-Liang Zheng, Jack W. Szostak, Matthew W. Powner
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85ac6358f879402fbd46a7cfa10cc7d9
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spelling	oai:doaj.org-article:85ac6358f879402fbd46a7cfa10cc7d92021-12-02T15:38:49ZDivergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides10.1038/ncomms152702041-1723https://doaj.org/article/85ac6358f879402fbd46a7cfa10cc7d92017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15270https://doaj.org/toc/2041-1723While mechanisms have been proposed for the prebiotic nucleotide synthesis, these require separate (and potentially incompatible) routes for pyrimidines and purines. Here the authors show that both of these classes of molecules can be formed by a divergent synthesis from a common prebiotic precursor.Shaun StairsArif NikmalDejan-Krešimir BučarShao-Liang ZhengJack W. SzostakMatthew W. PownerNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shaun Stairs Arif Nikmal Dejan-Krešimir Bučar Shao-Liang Zheng Jack W. Szostak Matthew W. Powner Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
description	While mechanisms have been proposed for the prebiotic nucleotide synthesis, these require separate (and potentially incompatible) routes for pyrimidines and purines. Here the authors show that both of these classes of molecules can be formed by a divergent synthesis from a common prebiotic precursor.
format	article
author	Shaun Stairs Arif Nikmal Dejan-Krešimir Bučar Shao-Liang Zheng Jack W. Szostak Matthew W. Powner
author_facet	Shaun Stairs Arif Nikmal Dejan-Krešimir Bučar Shao-Liang Zheng Jack W. Szostak Matthew W. Powner
author_sort	Shaun Stairs
title	Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
title_short	Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
title_full	Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
title_fullStr	Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
title_full_unstemmed	Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
title_sort	divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/85ac6358f879402fbd46a7cfa10cc7d9
work_keys_str_mv	AT shaunstairs divergentprebioticsynthesisofpyrimidineand8oxopurineribonucleotides AT arifnikmal divergentprebioticsynthesisofpyrimidineand8oxopurineribonucleotides AT dejankresimirbucar divergentprebioticsynthesisofpyrimidineand8oxopurineribonucleotides AT shaoliangzheng divergentprebioticsynthesisofpyrimidineand8oxopurineribonucleotides AT jackwszostak divergentprebioticsynthesisofpyrimidineand8oxopurineribonucleotides AT matthewwpowner divergentprebioticsynthesisofpyrimidineand8oxopurineribonucleotides
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Divergent prebiotic synthesis of pyrimidine and 8-oxo-purine ribonucleotides

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