Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses

Background: Taxanes [paclitaxel, nab-paclitaxel (Abraxane, Celgene Corp, USA), and docetaxel]—used in the treatment of lung, breast, and head and neck cancers—have been associated with cutaneous adverse effects, including photodermatoses. Purpose: We describe a woman with non-small cell lung can...

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Autores principales:	Bryce D. Beutler, Philip R. Cohen
Formato:	article
Lenguaje:	EN
Publicado:	Mattioli1885 2015
Materias:	Abraxane albumin Cremophor docetaxel Kolliphor nab-paclitaxel Dermatology RL1-803
Acceso en línea:	https://doaj.org/article/85ac867e0b9c4e93984f91d82add7b20
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spelling	oai:doaj.org-article:85ac867e0b9c4e93984f91d82add7b202021-11-17T08:31:38ZNab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses10.5826/dpc.0502a242160-9381https://doaj.org/article/85ac867e0b9c4e93984f91d82add7b202015-04-01T00:00:00Zhttp://dpcj.org/index.php/dpc/article/view/826https://doaj.org/toc/2160-9381 Background: Taxanes [paclitaxel, nab-paclitaxel (Abraxane, Celgene Corp, USA), and docetaxel]—used in the treatment of lung, breast, and head and neck cancers—have been associated with cutaneous adverse effects, including photodermatoses. Purpose: We describe a woman with non-small cell lung cancer who developed a photodistributed dermatitis associated with her nab-paclitaxel therapy and review photodermatoses in patients receiving taxanes. Materials and methods: The features of a woman with a nab-paclitaxel-associated photodistributed dermatitis are presented and the literature on nab-paclitaxel-associated photosensitivity is reviewed. Results: Our patient developed nab-paclitaxel-associated photodistributed dermatitis on the sun-exposed surfaces of her upper extremities, which was exacerbated with each course of nab-paclitaxel. Biopsies revealed an interface dermatitis and laboratory studies were negative for lupus erythematosus and dermatomyositis. Her condition improved following topical corticosteroid cream application and strict avoidance of sunlight. Conclusion: Chemotherapy can be associated with adverse mucocutaneous events, including dermatoses on sun-exposed areas of the skin. Paclitaxel and nab-paclitaxel have both been associated with photodermatoses, including dermatitis, erythema multiforme, onycholysis, and subacute cutaneous lupus erythematosus. Strict avoidance of sun exposure, topical or oral corticosteroids, and/or discontinuation of the drug results in improvement with progressive resolution of symptoms and skin lesions. Development of photodermatoses is not an absolute contraindication to continuing chemotherapy, provided that the cutaneous condition resolves with dermatosis-directed treatment and the patient avoids sun exposure. Bryce D. BeutlerPhilip R. CohenMattioli1885articleAbraxanealbuminCremophordocetaxelKolliphornab-paclitaxelDermatologyRL1-803ENDermatology Practical & Conceptual (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Abraxane albumin Cremophor docetaxel Kolliphor nab-paclitaxel Dermatology RL1-803
spellingShingle	Abraxane albumin Cremophor docetaxel Kolliphor nab-paclitaxel Dermatology RL1-803 Bryce D. Beutler Philip R. Cohen Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses
description	Background: Taxanes [paclitaxel, nab-paclitaxel (Abraxane, Celgene Corp, USA), and docetaxel]—used in the treatment of lung, breast, and head and neck cancers—have been associated with cutaneous adverse effects, including photodermatoses. Purpose: We describe a woman with non-small cell lung cancer who developed a photodistributed dermatitis associated with her nab-paclitaxel therapy and review photodermatoses in patients receiving taxanes. Materials and methods: The features of a woman with a nab-paclitaxel-associated photodistributed dermatitis are presented and the literature on nab-paclitaxel-associated photosensitivity is reviewed. Results: Our patient developed nab-paclitaxel-associated photodistributed dermatitis on the sun-exposed surfaces of her upper extremities, which was exacerbated with each course of nab-paclitaxel. Biopsies revealed an interface dermatitis and laboratory studies were negative for lupus erythematosus and dermatomyositis. Her condition improved following topical corticosteroid cream application and strict avoidance of sunlight. Conclusion: Chemotherapy can be associated with adverse mucocutaneous events, including dermatoses on sun-exposed areas of the skin. Paclitaxel and nab-paclitaxel have both been associated with photodermatoses, including dermatitis, erythema multiforme, onycholysis, and subacute cutaneous lupus erythematosus. Strict avoidance of sun exposure, topical or oral corticosteroids, and/or discontinuation of the drug results in improvement with progressive resolution of symptoms and skin lesions. Development of photodermatoses is not an absolute contraindication to continuing chemotherapy, provided that the cutaneous condition resolves with dermatosis-directed treatment and the patient avoids sun exposure.
format	article
author	Bryce D. Beutler Philip R. Cohen
author_facet	Bryce D. Beutler Philip R. Cohen
author_sort	Bryce D. Beutler
title	Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses
title_short	Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses
title_full	Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses
title_fullStr	Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses
title_full_unstemmed	Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses
title_sort	nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses
publisher	Mattioli1885
publishDate	2015
url	https://doaj.org/article/85ac867e0b9c4e93984f91d82add7b20
work_keys_str_mv	AT brycedbeutler nabpaclitaxelassociatedphotosensitivityreportinawomanwithnonsmallcelllungcancerandreviewoftaxanerelatedphotodermatoses AT philiprcohen nabpaclitaxelassociatedphotosensitivityreportinawomanwithnonsmallcelllungcancerandreviewoftaxanerelatedphotodermatoses
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Nab-paclitaxel-associated photosensitivity: report in a woman with non-small cell lung cancer and review of taxane-related photodermatoses

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