Three-component radical homo Mannich reaction

Due to the ionic nature of its mechanism, the Mannich reaction can only use non-enolizable aldehydes as substrates. Here, the authors expand the scope of the classical Mannich reaction to enolizable aldehydes by employing a radical process resulting in a streamlined synthesis of γ-amino-carbonyl com...

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Autores principales:	Shuai Shi, Wenting Qiu, Pannan Miao, Ruining Li, Xianfeng Lin, Zhankui Sun
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85b17ab32aad4d6a8bd0bf6d8e2bdfaa
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id	oai:doaj.org-article:85b17ab32aad4d6a8bd0bf6d8e2bdfaa
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spelling	oai:doaj.org-article:85b17ab32aad4d6a8bd0bf6d8e2bdfaa2021-12-02T13:30:15ZThree-component radical homo Mannich reaction10.1038/s41467-021-21303-32041-1723https://doaj.org/article/85b17ab32aad4d6a8bd0bf6d8e2bdfaa2021-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21303-3https://doaj.org/toc/2041-1723Due to the ionic nature of its mechanism, the Mannich reaction can only use non-enolizable aldehydes as substrates. Here, the authors expand the scope of the classical Mannich reaction to enolizable aldehydes by employing a radical process resulting in a streamlined synthesis of γ-amino-carbonyl compounds.Shuai ShiWenting QiuPannan MiaoRuining LiXianfeng LinZhankui SunNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shuai Shi Wenting Qiu Pannan Miao Ruining Li Xianfeng Lin Zhankui Sun Three-component radical homo Mannich reaction
description	Due to the ionic nature of its mechanism, the Mannich reaction can only use non-enolizable aldehydes as substrates. Here, the authors expand the scope of the classical Mannich reaction to enolizable aldehydes by employing a radical process resulting in a streamlined synthesis of γ-amino-carbonyl compounds.
format	article
author	Shuai Shi Wenting Qiu Pannan Miao Ruining Li Xianfeng Lin Zhankui Sun
author_facet	Shuai Shi Wenting Qiu Pannan Miao Ruining Li Xianfeng Lin Zhankui Sun
author_sort	Shuai Shi
title	Three-component radical homo Mannich reaction
title_short	Three-component radical homo Mannich reaction
title_full	Three-component radical homo Mannich reaction
title_fullStr	Three-component radical homo Mannich reaction
title_full_unstemmed	Three-component radical homo Mannich reaction
title_sort	three-component radical homo mannich reaction
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/85b17ab32aad4d6a8bd0bf6d8e2bdfaa
work_keys_str_mv	AT shuaishi threecomponentradicalhomomannichreaction AT wentingqiu threecomponentradicalhomomannichreaction AT pannanmiao threecomponentradicalhomomannichreaction AT ruiningli threecomponentradicalhomomannichreaction AT xianfenglin threecomponentradicalhomomannichreaction AT zhankuisun threecomponentradicalhomomannichreaction
_version_	1718392926457823232

Three-component radical homo Mannich reaction

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