Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

Microbial production of aromatic amino acid (AAA)-derived chemicals remains an outstanding metabolic engineering challenge. Here, the authors engineer baker’s yeast for high levels p-coumaric acid production by rewiring the central carbon metabolism and channeling more flux to the AAA biosynthetic p...

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Autores principales:	Quanli Liu, Tao Yu, Xiaowei Li, Yu Chen, Kate Campbell, Jens Nielsen, Yun Chen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/85b8439535674a50b63d8be156d51506
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spelling	oai:doaj.org-article:85b8439535674a50b63d8be156d515062021-12-02T15:35:55ZRewiring carbon metabolism in yeast for high level production of aromatic chemicals10.1038/s41467-019-12961-52041-1723https://doaj.org/article/85b8439535674a50b63d8be156d515062019-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-12961-5https://doaj.org/toc/2041-1723Microbial production of aromatic amino acid (AAA)-derived chemicals remains an outstanding metabolic engineering challenge. Here, the authors engineer baker’s yeast for high levels p-coumaric acid production by rewiring the central carbon metabolism and channeling more flux to the AAA biosynthetic pathway.Quanli LiuTao YuXiaowei LiYu ChenKate CampbellJens NielsenYun ChenNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-13 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Quanli Liu Tao Yu Xiaowei Li Yu Chen Kate Campbell Jens Nielsen Yun Chen Rewiring carbon metabolism in yeast for high level production of aromatic chemicals
description	Microbial production of aromatic amino acid (AAA)-derived chemicals remains an outstanding metabolic engineering challenge. Here, the authors engineer baker’s yeast for high levels p-coumaric acid production by rewiring the central carbon metabolism and channeling more flux to the AAA biosynthetic pathway.
format	article
author	Quanli Liu Tao Yu Xiaowei Li Yu Chen Kate Campbell Jens Nielsen Yun Chen
author_facet	Quanli Liu Tao Yu Xiaowei Li Yu Chen Kate Campbell Jens Nielsen Yun Chen
author_sort	Quanli Liu
title	Rewiring carbon metabolism in yeast for high level production of aromatic chemicals
title_short	Rewiring carbon metabolism in yeast for high level production of aromatic chemicals
title_full	Rewiring carbon metabolism in yeast for high level production of aromatic chemicals
title_fullStr	Rewiring carbon metabolism in yeast for high level production of aromatic chemicals
title_full_unstemmed	Rewiring carbon metabolism in yeast for high level production of aromatic chemicals
title_sort	rewiring carbon metabolism in yeast for high level production of aromatic chemicals
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/85b8439535674a50b63d8be156d51506
work_keys_str_mv	AT quanliliu rewiringcarbonmetabolisminyeastforhighlevelproductionofaromaticchemicals AT taoyu rewiringcarbonmetabolisminyeastforhighlevelproductionofaromaticchemicals AT xiaoweili rewiringcarbonmetabolisminyeastforhighlevelproductionofaromaticchemicals AT yuchen rewiringcarbonmetabolisminyeastforhighlevelproductionofaromaticchemicals AT katecampbell rewiringcarbonmetabolisminyeastforhighlevelproductionofaromaticchemicals AT jensnielsen rewiringcarbonmetabolisminyeastforhighlevelproductionofaromaticchemicals AT yunchen rewiringcarbonmetabolisminyeastforhighlevelproductionofaromaticchemicals
_version_	1718386424335564800

Rewiring carbon metabolism in yeast for high level production of aromatic chemicals

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