A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis

The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiog...

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Autores principales: T. Azad, H. J. Janse van Rensburg, E. D. Lightbody, B. Neveu, A. Champagne, A. Ghaffari, V. R. Kay, Y. Hao, H. Shen, B. Yeung, B. A. Croy, K. L. Guan, F. Pouliot, J. Zhang, C. J. B. Nicol, X. Yang
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/85b8748f8e55400f94efb6cc36e66651
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spelling oai:doaj.org-article:85b8748f8e55400f94efb6cc36e666512021-12-02T14:40:55ZA LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis10.1038/s41467-018-03278-w2041-1723https://doaj.org/article/85b8748f8e55400f94efb6cc36e666512018-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03278-whttps://doaj.org/toc/2041-1723The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiogenesis.T. AzadH. J. Janse van RensburgE. D. LightbodyB. NeveuA. ChampagneA. GhaffariV. R. KayY. HaoH. ShenB. YeungB. A. CroyK. L. GuanF. PouliotJ. ZhangC. J. B. NicolX. YangNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
T. Azad
H. J. Janse van Rensburg
E. D. Lightbody
B. Neveu
A. Champagne
A. Ghaffari
V. R. Kay
Y. Hao
H. Shen
B. Yeung
B. A. Croy
K. L. Guan
F. Pouliot
J. Zhang
C. J. B. Nicol
X. Yang
A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
description The Hippo pathway is a major orchestrator of organ development and homeostasis. Here Azad and colleagues develop a biosensor to monitor the activity of the Hippo pathway component LATS and identify VEGF signalling as an upstream regulator of LATS, supporting a role for Hippo signalling during angiogenesis.
format article
author T. Azad
H. J. Janse van Rensburg
E. D. Lightbody
B. Neveu
A. Champagne
A. Ghaffari
V. R. Kay
Y. Hao
H. Shen
B. Yeung
B. A. Croy
K. L. Guan
F. Pouliot
J. Zhang
C. J. B. Nicol
X. Yang
author_facet T. Azad
H. J. Janse van Rensburg
E. D. Lightbody
B. Neveu
A. Champagne
A. Ghaffari
V. R. Kay
Y. Hao
H. Shen
B. Yeung
B. A. Croy
K. L. Guan
F. Pouliot
J. Zhang
C. J. B. Nicol
X. Yang
author_sort T. Azad
title A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
title_short A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
title_full A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
title_fullStr A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
title_full_unstemmed A LATS biosensor screen identifies VEGFR as a regulator of the Hippo pathway in angiogenesis
title_sort lats biosensor screen identifies vegfr as a regulator of the hippo pathway in angiogenesis
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/85b8748f8e55400f94efb6cc36e66651
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