IRE1α-XBP1 but not PERK inhibition exerts anti-tumor activity in osteosarcoma
Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor. However, the therapeutic results of the advanced cases at the first visit were still extremely poor. Therefore, more effective therapeutic options based on molecular profiling of OS are needed. In this study, we investigated...
Guardado en:
Autores principales: | Keita Sasa, Tsuyoshi Saito, Taisei Kurihara, Nobuhiko Hasegawa, Kei Sano, Daisuke Kubota, Keisuke Akaike, Taketo Okubo, Takuo Hayashi, Tatsuya Takagi, Takashi Yao, Muneaki Ishijima, Yoshiyuki Suehara |
---|---|
Formato: | article |
Lenguaje: | EN |
Publicado: |
Springer
2021
|
Materias: | |
Acceso en línea: | https://doaj.org/article/85b9019b871845f2aaa55cdf3b4a35f5 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
Ejemplares similares
-
The IRE1/XBP1 signaling axis promotes skeletal muscle regeneration through a cell non-autonomous mechanism
por: Anirban Roy, et al.
Publicado: (2021) -
A Human IRE1 Inhibitor Blocks the Unfolded Protein Response in the Pathogenic Fungus <named-content content-type="genus-species">Aspergillus fumigatus</named-content> and Suggests Noncanonical Functions within the Pathway
por: José P. Guirao-Abad, et al.
Publicado: (2020) -
Icariin inhibits the expression of IL-1β, IL-6 and TNF-α induced by OGD/R through the IRE1/XBP1s pathway in microglia
por: Zhen-Tao Mo, et al.
Publicado: (2021) -
Downregulation of microRNA-512-3p enhances the viability and suppresses the apoptosis of vascular endothelial cells, alleviates autophagy and endoplasmic reticulum stress as well as represses atherosclerotic lesions in atherosclerosis by adjusting spliced/unspliced ratio of X-box binding protein 1 (XBP-1S/XBP-1U)
por: Peipei Ge, et al.
Publicado: (2021) -
Tratamiento adyuvante (Conpadri I) en osteosarcoma infantil (Valdivia 1980-1990)
por: Zolezzi R,Paola, et al.
Publicado: (1992)