IRE1α-XBP1 but not PERK inhibition exerts anti-tumor activity in osteosarcoma
Abstract Osteosarcoma (OS) is the most common primary malignant bone tumor. However, the therapeutic results of the advanced cases at the first visit were still extremely poor. Therefore, more effective therapeutic options based on molecular profiling of OS are needed. In this study, we investigated...
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Auteurs principaux: | Keita Sasa, Tsuyoshi Saito, Taisei Kurihara, Nobuhiko Hasegawa, Kei Sano, Daisuke Kubota, Keisuke Akaike, Taketo Okubo, Takuo Hayashi, Tatsuya Takagi, Takashi Yao, Muneaki Ishijima, Yoshiyuki Suehara |
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Format: | article |
Langue: | EN |
Publié: |
Springer
2021
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Sujets: | |
Accès en ligne: | https://doaj.org/article/85b9019b871845f2aaa55cdf3b4a35f5 |
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