The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis

Abstract The SEPT9 gene methylation assay is the first FDA-approved blood assay for colorectal cancer (CRC) screening. Fecal immunochemical test (FIT), FIT-DNA test and CEA assay are also in vitro diagnostic (IVD) tests used in CRC screening. This meta-analysis aims to review the SEPT9 assay perform...

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Autores principales:	Lele Song, Jia Jia, Xiumei Peng, Wenhua Xiao, Yuemin Li
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/85bc8435fe9c4196991cda2e5dc58d96
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spelling	oai:doaj.org-article:85bc8435fe9c4196991cda2e5dc58d962021-12-02T15:06:09ZThe performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis10.1038/s41598-017-03321-82045-2322https://doaj.org/article/85bc8435fe9c4196991cda2e5dc58d962017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03321-8https://doaj.org/toc/2045-2322Abstract The SEPT9 gene methylation assay is the first FDA-approved blood assay for colorectal cancer (CRC) screening. Fecal immunochemical test (FIT), FIT-DNA test and CEA assay are also in vitro diagnostic (IVD) tests used in CRC screening. This meta-analysis aims to review the SEPT9 assay performance and compare it with other IVD CRC screening tests. By searching the Ovid MEDLINE, EMBASE, CBMdisc and CJFD database, 25 out of 180 studies were identified to report the SEPT9 assay performance. 2613 CRC cases and 6030 controls were included, and sensitivity and specificity were used to evaluate its performance at various algorithms. 1/3 algorithm exhibited the best sensitivity while 2/3 and 1/1 algorithm exhibited the best balance between sensitivity and specificity. The performance of the blood SEPT9 assay is superior to that of the serum protein markers and the FIT test in symptomatic population, while appeared to be less potent than FIT and FIT-DNA tests in asymptomatic population. In conclusion, 1/3 algorithm is recommended for CRC screening, and 2/3 or 1/1 algorithms are suitable for early detection for diagnostic purpose. The SEPT9 assay exhibited better performance in symptomatic population than in asymptomatic population.Lele SongJia JiaXiumei PengWenhua XiaoYuemin LiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lele Song Jia Jia Xiumei Peng Wenhua Xiao Yuemin Li The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis
description	Abstract The SEPT9 gene methylation assay is the first FDA-approved blood assay for colorectal cancer (CRC) screening. Fecal immunochemical test (FIT), FIT-DNA test and CEA assay are also in vitro diagnostic (IVD) tests used in CRC screening. This meta-analysis aims to review the SEPT9 assay performance and compare it with other IVD CRC screening tests. By searching the Ovid MEDLINE, EMBASE, CBMdisc and CJFD database, 25 out of 180 studies were identified to report the SEPT9 assay performance. 2613 CRC cases and 6030 controls were included, and sensitivity and specificity were used to evaluate its performance at various algorithms. 1/3 algorithm exhibited the best sensitivity while 2/3 and 1/1 algorithm exhibited the best balance between sensitivity and specificity. The performance of the blood SEPT9 assay is superior to that of the serum protein markers and the FIT test in symptomatic population, while appeared to be less potent than FIT and FIT-DNA tests in asymptomatic population. In conclusion, 1/3 algorithm is recommended for CRC screening, and 2/3 or 1/1 algorithms are suitable for early detection for diagnostic purpose. The SEPT9 assay exhibited better performance in symptomatic population than in asymptomatic population.
format	article
author	Lele Song Jia Jia Xiumei Peng Wenhua Xiao Yuemin Li
author_facet	Lele Song Jia Jia Xiumei Peng Wenhua Xiao Yuemin Li
author_sort	Lele Song
title	The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis
title_short	The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis
title_full	The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis
title_fullStr	The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis
title_full_unstemmed	The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis
title_sort	performance of the sept9 gene methylation assay and a comparison with other crc screening tests: a meta-analysis
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/85bc8435fe9c4196991cda2e5dc58d96
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The performance of the SEPT9 gene methylation assay and a comparison with other CRC screening tests: A meta-analysis

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