Nanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male Rats

Zwe-Ling Kong,1 Jia-Ling He,1 Sabri Sudirman,2 Mao-Tien Kuo,3 Song Miao,4 Ke-Liang B Chang,1 David Tsou1 1Department of Food Science, National Taiwan Ocean University, Keelung City, Taiwan; 2Fisheries Product Technology, Faculty of Agriculture, Universitas Sriwijaya, Palembang, Ogan Ilir Regency, In...

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Autores principales: Kong ZL, He JL, Sudirman S, Kuo MT, Miao S, Chang KLB, Tsou D
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Publicado: Dove Medical Press 2020
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spelling oai:doaj.org-article:85bd4a3a686041e99b86ed623549f83b2021-12-02T10:20:59ZNanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male Rats1178-2013https://doaj.org/article/85bd4a3a686041e99b86ed623549f83b2020-06-01T00:00:00Zhttps://www.dovepress.com/nanoparticles-of-antroquinonol-rich-extract-from-solid-state-cultured--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Zwe-Ling Kong,1 Jia-Ling He,1 Sabri Sudirman,2 Mao-Tien Kuo,3 Song Miao,4 Ke-Liang B Chang,1 David Tsou1 1Department of Food Science, National Taiwan Ocean University, Keelung City, Taiwan; 2Fisheries Product Technology, Faculty of Agriculture, Universitas Sriwijaya, Palembang, Ogan Ilir Regency, Indonesia; 3Lantyng Biotech, Co. Ltd., Taipei City, Taiwan; 4Teagasc Food Research Center, Moorepark, Co. Cork, IrelandCorrespondence: Zwe-Ling Kong Tel +886-24622192 #5130 Email kongzl@mail.ntou.edu.twPurpose: To characterize the nanoparticle of antroquinonol from A. cinnamomea and its ameliorative effects on the reproductive dysfunction in the diabetic male rat.Material and Methods: The chitosan-silicate nanoparticle was used as the carrier for the delivery of antroquinonol from solid-state-cultured A. cinnamomea extract (AC). The rats were fed with a high-fat diet and intraperitoneally injected with streptozotocin to induce diabetes. The rats were daily oral gavage by water [Diabetes (DM) and Control groups], three different doses of chitosan-silicate nanoparticle of antroquinonol from solid-state-cultured A. cinnamomea (nano-SAC, NAC): (DM+NAC1x, 4 mg/kg of body weight; DM+NAC2x, 8 mg/kg; and DM+NAC5x, 20 mg/kg), solid-state-cultured AC (DM+AC5x, 20 mg/kg), or metformin (DM+Met, 200 mg/kg) for 7 weeks.Results: The nano-SAC size was 37.68± 5.91 nm, the zeta potential was 4.13± 0.49 mV, encapsulation efficiency was 79.29± 0.77%, and loading capacity was 32.45± 0.02%. The nano-SAC can improve diabetes-induced reproductive dysfunction by regulating glucose, insulin, and oxidative enzyme and by increasing the level of testosterone, follicle-stimulating hormone, luteinizing hormone, and sperm count as well as sperm mobility. In testicular histopathology, the seminiferous tubules of A. cinnamomea-supplemented diabetic rats showed similar morphology with the control group.Conclusion: The nanoparticle of antroquinonol from Antrodia cinnamomea can be used as an effective strategy to improve diabetes-induced testicular dysfunction.Keywords: Antrodia cinnamomea, antroquinonol, diabetes, nanoparticles, male reproductionKong ZLHe JLSudirman SKuo MTMiao SChang KLBTsou DDove Medical Pressarticleantrodia cinnamomeaantroquinonoldiabetesnanoparticlesmale reproductionMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 15, Pp 4191-4203 (2020)
institution DOAJ
collection DOAJ
language EN
topic antrodia cinnamomea
antroquinonol
diabetes
nanoparticles
male reproduction
Medicine (General)
R5-920
spellingShingle antrodia cinnamomea
antroquinonol
diabetes
nanoparticles
male reproduction
Medicine (General)
R5-920
Kong ZL
He JL
Sudirman S
Kuo MT
Miao S
Chang KLB
Tsou D
Nanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male Rats
description Zwe-Ling Kong,1 Jia-Ling He,1 Sabri Sudirman,2 Mao-Tien Kuo,3 Song Miao,4 Ke-Liang B Chang,1 David Tsou1 1Department of Food Science, National Taiwan Ocean University, Keelung City, Taiwan; 2Fisheries Product Technology, Faculty of Agriculture, Universitas Sriwijaya, Palembang, Ogan Ilir Regency, Indonesia; 3Lantyng Biotech, Co. Ltd., Taipei City, Taiwan; 4Teagasc Food Research Center, Moorepark, Co. Cork, IrelandCorrespondence: Zwe-Ling Kong Tel +886-24622192 #5130 Email kongzl@mail.ntou.edu.twPurpose: To characterize the nanoparticle of antroquinonol from A. cinnamomea and its ameliorative effects on the reproductive dysfunction in the diabetic male rat.Material and Methods: The chitosan-silicate nanoparticle was used as the carrier for the delivery of antroquinonol from solid-state-cultured A. cinnamomea extract (AC). The rats were fed with a high-fat diet and intraperitoneally injected with streptozotocin to induce diabetes. The rats were daily oral gavage by water [Diabetes (DM) and Control groups], three different doses of chitosan-silicate nanoparticle of antroquinonol from solid-state-cultured A. cinnamomea (nano-SAC, NAC): (DM+NAC1x, 4 mg/kg of body weight; DM+NAC2x, 8 mg/kg; and DM+NAC5x, 20 mg/kg), solid-state-cultured AC (DM+AC5x, 20 mg/kg), or metformin (DM+Met, 200 mg/kg) for 7 weeks.Results: The nano-SAC size was 37.68± 5.91 nm, the zeta potential was 4.13± 0.49 mV, encapsulation efficiency was 79.29± 0.77%, and loading capacity was 32.45± 0.02%. The nano-SAC can improve diabetes-induced reproductive dysfunction by regulating glucose, insulin, and oxidative enzyme and by increasing the level of testosterone, follicle-stimulating hormone, luteinizing hormone, and sperm count as well as sperm mobility. In testicular histopathology, the seminiferous tubules of A. cinnamomea-supplemented diabetic rats showed similar morphology with the control group.Conclusion: The nanoparticle of antroquinonol from Antrodia cinnamomea can be used as an effective strategy to improve diabetes-induced testicular dysfunction.Keywords: Antrodia cinnamomea, antroquinonol, diabetes, nanoparticles, male reproduction
format article
author Kong ZL
He JL
Sudirman S
Kuo MT
Miao S
Chang KLB
Tsou D
author_facet Kong ZL
He JL
Sudirman S
Kuo MT
Miao S
Chang KLB
Tsou D
author_sort Kong ZL
title Nanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male Rats
title_short Nanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male Rats
title_full Nanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male Rats
title_fullStr Nanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male Rats
title_full_unstemmed Nanoparticles of Antroquinonol-Rich Extract from Solid-State-Cultured Antrodia cinnamomea Improve Reproductive Function in Diabetic Male Rats
title_sort nanoparticles of antroquinonol-rich extract from solid-state-cultured antrodia cinnamomea improve reproductive function in diabetic male rats
publisher Dove Medical Press
publishDate 2020
url https://doaj.org/article/85bd4a3a686041e99b86ed623549f83b
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