A generic method for design of oligomer-specific antibodies.

A generic method for design of oligomer-specific antibodies.

Antibodies that preferentially and specifically target pathological oligomeric protein and peptide assemblies, as opposed to their monomeric and amyloid counterparts, provide therapeutic and diagnostic opportunities for protein misfolding diseases. Unfortunately, the molecular properties associated...

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Autores principales: Kristoffer Brännström, Malin Lindhagen-Persson, Anna L Gharibyan, Irina Iakovleva, Monika Vestling, Mikael E Sellin, Thomas Brännström, Ludmilla Morozova-Roche, Lars Forsgren, Anders Olofsson
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2014
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/85bdb2aa8c704054b936e00b43b5987b
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